The Effect of Histaminergic System on Nociceptin/Orphanin FQ Induced Food Intake in Chicken

British Poultry Science

Babapour

et al. 2015

The aim of the current study was to investigate the interaction of the nitric oxide and cannabinoidergic systems on feeding behaviour in neonatal chicken. A total of 6 experiments were designed to evaluate the interaction between cannabinoidergic and nitrergic systems on food intake in 3-h food-deprived (FD3) neonatal chickens. In Experiment 1, chickens received intracerebroventricular (ICV) injections of saline, 2-arachidonoylglycerol (2-AG) (a CB1 receptor agonist, 2 µg), l-arginine (nitric oxide precursor, 200 nmol) and co-administration of 2-AG + l-arginine. In Experiment 2, ICV injection of saline, 2-AG (2 µg), l-NAME (a nitric oxide synthesis inhibitor, 100 nmol) and their combination (2-AG + l-NAME) were applied to the birds. In Experiment 3, injections were saline, CB65 (a CB2 receptor agonist, 1.25 µg), l-arginine (200 nmol) and CB65 + l-arginine. In Experiment 4, birds received ICV injection of saline, CB65 (1.25 µg), l-NAME (100 nmol) and CB65 + l-NAME. In Experiment 5, chickens were ICV injected with saline, l-arginine (800 nmol), SR141716A (a selective CB1 receptor antagonist, 6.25 µg) and l-arginine + SR141716A. In Experiment 6, birds were injected with saline, l-arginine (800 nmol), AM630 (a selective CB2 receptor antagonist, 5 µg) and l-arginine + AM630. Cumulative food intake was recorded until 2-h post injection. ICV injection of CB1 and CB2 receptor agonists increased food intake. Co-injection of 2-AG + l-NAME increased the hyperphagic effects of CB1 receptors. CB2 receptor-induced food intake was not affected by co-administration of CB65 + l-NAME. l-Arginine decreased food intake and this effect was amplified by co-injection of l-arginine + SR141716A. However; CB2 receptor antagonists had no effect on l-arginine-induced hypophagia. The results suggest that there is an interaction between endogenous nitric oxide and the cannabinoidergic system on feeding behaviour which is mediated via CB1 receptors in the neonatal chicken.

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Endocannabinoid and nitric oxide interaction mediates food intake in neonatal chicken

Hassanpour

British Poultry Science

Babapour

et al. 2015

“…α-MSH blocks this neuropeptide effect, indicating that the AgRP and the CART neurons may mediate such a hyperphagic effect, as in mammals (Bungo et al 2009). The receptor of NE (β 2 ) and glutamate (NMDA and AMPA) can increase the hyperphagic effect of N/OFQ (Zendehdel et al 2017b;Abolghasempour et al 2019); the N/OFQ effect is enhanced by receptors of DA (D1 and D2) and histamine (H 1 ), but it is attenuated by H 3 (Zendehdel et al 2019(Zendehdel et al , 2015b.…”

Section: Nociceptin/orphanin Fq (N/ofq)mentioning

confidence: 99%

“…NO which has important physiological functions in the CNS, is produced from L-arginine by NO synthase (NOS). It has been reported that the central inhibition and stimulation of NO synthesis change feeding behavior in both meat-and layer-type chicken in different manners (Zendehdel et al 2015a(Zendehdel et al , 2015b(Zendehdel et al , 2015cKhan et al 2007;Choi et al 1994;Clonidine Choi et al 1995). In comparison with layers, the broiler chicks have genetically higher food consumption and energy expenditure in which the decremental alteration in feeding behavior has been observed through ICV injection of L-NNA but not L-NAME, the inhibitors of NO synthesis (Khan et al 2007;Choi, et al 1994).…”

Section: Nitric Oxide (No)mentioning

confidence: 99%

The Crosstalk Between Brain Mediators Regulating Food Intake Behavior in Birds: A Review

Rahmani

Ghashghayi

et al. 2021

Int J Pept Res Ther

Self Cite

Appetite is controlled by a complex system of central and peripheral signals interacting to modulate the ingestion response. Several brain mediators with complex networks adjust food intake in birds. Based on the available literature, these mediators have interactions with a number of other neurotransmitters (NT S ) involved in feed intake. It means that, NT S regulate feeding behavior through mediating other peptide and NTs activity. In birds, insulin known as a hypophagic hormone that is interplaying with neuropeptide Y (NPY), pro-opiomelanocortin (POMC), and corticotropin-releasing factor (CRF) in brain. Another hormone ghrelin, inhibits food intake in birds and other mediators, such as glutamate, endocannabinoid system (ECS), serotonin (5-hydroxytryptamine, 5-HT), and norepinephrine (NE), which play a key role in ghrelin-induced hypophagia. Another involved peptide on feeding behavior in chickens called nociceptin/orphanin FQ (N/OFQ) is modulated by histamine, glutamate, dopamine (DA), gamma-aminobutyric acid (GABA), agouti-related protein (AgRP), and cocaine and amphetamine-regulated transcript (CART). Some of the NT S such as opioid have both orexigenic and anorexigenic effects in birds while has interaction with NE, glutamate, histamine, DA, and cannabinoids (CBs). Thus, interaction among mediators is a prominent process needs to be considered in order to understanding the mechanisms underlying feed intake regulation in birds. This review aims to investigate the role of major regulators and their mediatory interactions with one another in poultry feeding behavior. According to mentioned interactions, it seems that dopamine, serotonin, and glutamate have the most interactions with other NT systems. Therefore, they play an axial role in the central regulation of food intake in CNS.

“…Each bird just used once in each experimental group. These doses of antagonists and N/OFQ were calculated based on previous and pilot studies Abbasnejad et al 2005;Tachibana et al 2009;Zendehdel and Hassanpour 2014;Zendehdel et al 2013Zendehdel et al , 2015.…”

Section: Food Intake Measurement Proceduresmentioning

confidence: 99%

Interaction Between Nociceptin/Orphanin FQ and Adrenergic System on Food Intake in Neonatal Chicken

Parvizi

Hassanpour

et al. 2016

Int J Pept Res Ther

Self Cite

The information emerging from the studies demonstrates adrenergic system and nociceptin/orphanin FQ (N/OFQ) play a crucial role on appetite regulation but there is no information for their interaction. The purpose of this study was to examine the effects of intracerebroventricular (ICV) injection of prazosin (a 1 receptor antagonist), yohimbine (a 2 receptor antagonist), metoprolol (b 1 adrenergic receptor antagonist), ICI 118,551 (b 2 adrenergic receptor antagonist) and SR59230R (b 3 adrenergic receptor antagonist) on N/OFQ-induced hyperphagia by 3-h fooddeprived neonatal broiler chicken. In experiment 1, chicken injected with saline, prazosin (10 nmol), N/OFQ (16 nmol) and co-injection of prazosin ? N/OFQ. In experiment 2, ICV injection of saline, yohimbine (13 nmol), N/OFQ (16 nmol) and yohimbine ? N/OFQ applied to the birds. In experiment 3, injections were saline, metoprolol (24 nmol), N/OFQ (16 nmol) and metoprolol ? N/OFQ. In experiment 4, the birds received ICV injection of saline, ICI 118,551 (5 nmol), (C) N/OFQ (16 nmol) and co-administration of ICI 118,551 ? N/OFQ. In experiment 5, chicken injected with saline, SR59230R (20 nmol), N/OFQ (16 nmol) and SR59230R ? N/OFQ. Then, cumulative food intake was recorded until 120 min after injection.According to the results, ICV injection of N/OFQ significantly increased food intake (P \ 0.001). The effect of N/OFQ significantly amplified by co-injection of N/OFQ ? b 2 adrenergic receptor antagonist (P \ 0.001). Also, administration of b 1 or b 3 adrenergic receptor antagonist had no effect on N/OFQ-induced hyperphagia (P [ 0.05). These results suggest that the effect of N/OFQ on cumulative food intake is mediated via b 2 adrenergic receptors in neonatal chicken.