The Effect of Highly Active Antiretroviral Therapy on the Survival of HIV-Infected Children in a Resource-Deprived Setting: A Cohort Study

Abstract

This observational cohort study by Andrew Edmonds and colleagues reports that treatment with highly active antiretroviral therapy (HAART) markedly improves the survival of HIV-infected children in Kinshasa, DRC, a resource-deprived setting.

Early infant diagnosis of HIV infection in Zambia through mobile phone texting of blood test results

“…There is strong evidence that the early initiation of ART in HIV-infected children can substantially reduce HIV-related morbidity and mortality. [3][4][5][6] In the guidelines it published in 2010, the World Health Organization (WHO) recommended the immediate initiation of ART upon diagnosis of HIV infection in infants and older children, irrespective of the children's CD4+ T-lymphocyte counts. 7 The early initiation of ART in infants requires reliable early infant diagnosis.…”

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir

“…urrently available combination antiretroviral therapy (cART) for human immunodeficiency virus type 1 (HIV-1) infection and AIDS potently suppresses the replication of HIV-1 and significantly extends the life expectancy of HIV-1-infected individuals (1)(2)(3)(4). Recent analyses have revealed that mortality rates for HIV-1-infected persons have become close to that of general population and that the recent first-line cART with integrase inhibitors or boosted protease inhibitor (PI)-based regimens has made the development of HIV-1 resistance significantly less likely over an extended period of time (5,6).…”

Attrition and Loss to Follow-up Among Children and Adolescents in a Community Home-Based Care HIV Programme in Uganda

“…The availabilty and rapid scaling up of Antiretroviral Therapy (ART) programmes for infants and children with Human Immunodeficiency Virus (HIV) infection in Low-Middle Income Countries (LMIC) has enabled many to survive and grow into adolescents and adults [1][2][3]. However, retention in care of children and adolescents with HIV remains a major operational challenge requiring innovation and creativity [4][5][6].…”