The effect of high fat, high sugar, and combined high fat-high sugar diets on spatial learning and memory in rodents: A meta-analysis

Abbott, Kirsten N.; Arnott, Christopher K.; Westbrook, R. Frederick; Tran, Da T.

doi:10.1016/j.neubiorev.2019.08.010

Cited by 74 publications

(44 citation statements)

References 114 publications

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“…Interestingly, overweight/obese children present reduced hippocampal volumes (Bauer et al, 2015) and increased amygdala activation (Boutelle et al, 2015). Similar patterns have been reported in HFD animal models (Abbott et al, 2019;Bose et al, 2009). Therefore, hippocampus and amygdala may then be highly vulnerable to the long-term deleterious effects of periadolescent HFD.…”

Section: Introductionsupporting

confidence: 61%

Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations

Naneix

Bakoyiannis

Santoyo-Zedillo

et al. 2020

Preprint

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1ABSTRACTIn addition to numerous metabolic comorbidities, obesity is associated with several adverse neurobiological outcomes, especially learning and memory alterations. Obesity prevalence is rising dramatically in youth and is persisting in adulthood. This is especially worrying since adolescence is a crucial period for the maturation of certain brain regions playing a central role in memory processes such as the hippocampus and the amygdala. We previously showed that periadolescent exposure to obesogenic high-fat diet (HFD) had opposite effects on hippocampus- and amygdala-dependent memory, impairing the former and enhancing the latter. However, the causal role of these two brain regions in periadolescent HFD-induced memory alterations remains unclear. Here, we first showed that periadolescent HFD induced long-term, but not short-term, object recognition memory deficits, specifically when rats were exposed to a novel context. Using chemogenetic approaches to inhibit targeted brain regions, we then demonstrated that recognition memory deficits are dependent on the activity of the ventral hippocampus, but not the basolateral amygdala. On the contrary, the HFD-induced enhancement of conditioned odor aversion requires specifically amygdala activity. Taken together, these findings suggest that HFD consumption throughout adolescence impairs long-term object recognition memory through the overactivation of the ventral hippocampus during memory acquisition. Moreover, these results further highlight the bidirectional effects of adolescent HFD on hippocampal and amygdala functions.

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Section: Introductionsupporting

confidence: 61%

Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations

Naneix

Bakoyiannis

Santoyo-Zedillo

et al. 2020

Preprint

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“…In the idiopathic, sino-nasal disease, trauma and miscellaneous group, there was evidence in each case that better olfactory performance was linked to a poorer diet, namely one adhering more to a Western-style dietary pattern—a pattern that animal data indicate is harmful to brain and physical health by promoting excess food intake [ 31 , 32 ]. There may be several possible explanations for this association.…”

Section: Discussionmentioning

confidence: 99%

The Aetiology of Olfactory Dysfunction and Its Relationship to Diet Quality

et al. 2020

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People with olfactory loss may choose foods rich in sugar, salt and fat to compensate their loss—foods that constitute a Western-style diet (WSD). However, olfactory dysfunction has not been consistently linked to any particular type of dietary change. Here we considered whether the aetiology of olfactory dysfunction may affect consumption of a WSD. Two-hundred and twenty-two people with olfactory dysfunction of varying cause, were tested for chemosensory performance and their frequency of consumption of a WSD. There was no evidence of a link between a WSD and olfactory dysfunction at the aggregate level, but an aetiology-based approach revealed various patterns, showing both positive and negative associations between olfactory performance and consumption of a WSD. We suggest a number of reasons why, in certain cases, greater olfactory dysfunction may be linked to lower intakes of a WSD, and the role that different aetiologies may have in affecting choices for foods that may appeal following olfactory impairment.

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“…McLean et al 2018more recently demonstrated impaired episodic and contextual memory performance after just one day of exposure to a high fat diet, and others have found similar rapid impairments as a result of Western diets (Beilharz, Maniam, & Morris, 2014;Tran & Westbrook, 2015). Mechanistically, Western diets might impair mnemonic performance via neuroinflammation (Beilharz, Maniam, & Morris, 2015;Freeman, Haley-Zitlin, Rosenberger, & Granholm, 2014;Veniaminova et al, 2020), reduced neuroplasticity (Abbott et al, 2019;Morin et al, 2017;Spinelli et al, 2017), decreased blood brain barrier function (Davidson et al, 2012;Hargrave, Davidson, Zheng, & Kinzig, 2016;Kanoski, Zhang, Zheng, & Davidson, 2010), and altered neuroendocrine (e.g., leptin, ghrelin, insulin) signaling (Kanoski & Grill, 2017;Suarez, Noble, & Kanoski, 2019). These diets might also impair memory performance through their effects on other cognitive processes, such as motivation (Blaisdell et al, 2014) and sustained attention (Blaisdell et al, 2017).…”

Section: Eating Ailments and Memorymentioning

confidence: 98%

“…The results from non-human animal studies tell a similar, albeit better controlled, story as those discussed above. A large number of studies in rats and mice have shown dietary induced obesity-or consuming diets known to cause obesity-results in rapid impairment on memory tasks, with the strongest deficits being to spatial memory (Abbott, Arnott, Westbrook, & Tran, 2019;Cordner & Tamashiro, 2015). As an example, put rats on a diet high in fat and sugar (hereafter a Western diet) and showed impairments in a spatial memory task after only 72 hours and stable deficits to working memory were observed after 30 days on the diet.…”

Section: Eating Ailments and Memorymentioning

confidence: 99%

Eating Behavior as a New Frontier in Memory Research

Seitz¹,

Tomiyama²,

Blaisdell³

2020

Preprint

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The study of memory is commonly associated with neuroscience, aging, education, and eyewitness testimony. Here we discuss how eating behavior is also heavily intertwined—and yet considerably understudied in its relation to memory processes. Both are influenced by similar neuroendocrine signals (e.g., leptin and ghrelin) and are dependent on hippocampal functions. While learning processes have long been implicated in influencing eating behavior, recent research has shed light on how memory of recent eating modulates future food consumption. In humans, overweight and obesity is associated with impaired memory performance, and studies in rodents (and to a lesser extent humans) show that dietary-induced obesity causes rapid decrements to memory. Lesions to the hippocampus not only disrupt memory, but also induce obesity, highlighting a cyclic relationship between obesity and memory impairment. Enhancing memory of eating has been shown to reduce future eating and yet, very little is known about what influences memory of eating or how memory of eating differs from memory for other behaviors. We discuss recent advancements in these areas and highlight fruitful research pursuits afforded by combining the study of memory with the study of eating behavior.

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The effect of high fat, high sugar, and combined high fat-high sugar diets on spatial learning and memory in rodents: A meta-analysis

Cited by 74 publications

References 114 publications

Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations

Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations

The Aetiology of Olfactory Dysfunction and Its Relationship to Diet Quality

Eating Behavior as a New Frontier in Memory Research

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