The effect of high-definition transcranial direct current stimulation on pain processing in a healthy population: A single-blinded crossover controlled study

Jiang, Xue; Wang, Yafei; Wan, Ruihan; Feng, Beibei; Zhang, Ziping; Lin, Yangyang; Wang, Yuling

doi:10.1016/j.neulet.2021.136304

Cited by 10 publications

(22 citation statements)

References 40 publications

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“…Several studies have reported PPT findings in line with Study I in healthy subjects 201,208,209 . While Jürgens et al and Lerma-Lara utilized the conventional M1-tDCS montage 209 , both Wan et al 210 and Jiang et al 208 utilized HD-tDCS montages identical to the M1-tDCS montage of Study I. The overall conflicting findings make it difficult to draw conclusions on the modulatory efficacy of HD-tDCS on PPTs in healthy subjects.…”

Section: Pressure Pain Thresholdsupporting

confidence: 77%

“…Interestingly the CPM PTT of the Pain DLPFC+M1-tDCS group was negative at baseline, indicating highly variable or possibly dysfunctional CPM mechanisms 241,256 in this group before any intervention was administered. Large intersubject variability of CPM has previously been reported 208,299 and is not detrimental to the study design, as the baseline values were not significantly different between the groups. The findings contradict the hypothesis of the effect of the experimental persistent pain, which was assumed to inhibit the CPM.…”

Section: Conditioned Pain Modulationmentioning

confidence: 51%

“…The overall conflicting findings make it difficult to draw conclusions on the modulatory efficacy of HD-tDCS on PPTs in healthy subjects. However, the most recent studies 186,201,208,211 all point towards HD-tDCS not being significantly more efficient than Sham-tDCS at modulating pressure sensitivity.…”

Section: Pressure Pain Thresholdmentioning

confidence: 99%

“…These findings conflict with Study I, indicating that modulation of thermal thresholds may be possible with different tDCS configurations but that the individual thermal modalities may respond differently. 201,208,209,227,228 . These studies demonstrating non-significant results strengthen the reliability of the results of Study I.…”

Section: Figure 12 Mean (±Sem) Cold Detection Threshold (Cdt) Heat De...mentioning

confidence: 99%

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Modulating the somatosensory system using high-definition transcranial direct current stimulation

Kold¹

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Section: Pressure Pain Thresholdsupporting

confidence: 77%

Section: Conditioned Pain Modulationmentioning

confidence: 51%

Section: Pressure Pain Thresholdmentioning

confidence: 99%

Section: Figure 12 Mean (±Sem) Cold Detection Threshold (Cdt) Heat De...mentioning

confidence: 99%

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Modulating the somatosensory system using high-definition transcranial direct current stimulation

Kold¹

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“…Randomization was done by a third party that prior to the experiment, had assigned the subject IDs to the four corresponding groups. The sample size was based on detecting a small to medium effect size, with 80% power and an alpha level of 0.05, and is in line with similar studies (Flood et al, 2016;Giannoni-Luza et al, 2020;Ihle et al, 2014;Jiang et al, 2022;Pinto et al, 2018;Wan et al, 2021).…”

Section: Participantsmentioning

confidence: 81%

Modulation of central pain mechanisms using high‐definition transcranial direct current stimulation: A double‐blind, sham‐controlled study

Kold

Graven‐Nielsen

2022

European Journal of Pain

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Background:The use of high-definition transcranial direct current stimulation (HD-tDCS) has shown analgesic effects in some chronic pain patients, but limited anti-nociceptive effects in healthy asymptomatic subjects. Methods: This double-blinded sham-controlled study assessed the effects of HD-tDCS applied on three consecutive days on central pain mechanisms in healthy participants with (N = 40) and without (N = 40) prolonged experimental pain induced by intramuscular injection of nerve growth factor into the right hand on Day 1. Participants were randomly assigned to Sham-tDCS (N = 20 with pain, N = 20 without) or Active-tDCS (N = 20 with pain, N = 20 without) targeting simultaneously the primary motor cortex and dorsolateral prefrontal cortex for 20 min with 2 mA stimulation intensity. Central pain mechanisms were assessed by cuff algometry on the legs measuring pressure pain sensitivity, temporal summation of pain (TSP) and conditioned pain modulation (CPM), at baseline and after HD-tDCS on Day 2 and Day 3. Based on subject's assessment of received HD-tDCS (sham or active), they were effectively blinded. Results: Compared with Sham-tDCS, Active-tDCS did not significantly reduce the average NGF-induced pain intensity. Tonic pain-induced temporal summation at Day 2 and Day 3 was significantly lower in the NGF-pain group under Active-tDCS compared to the pain group with Sham-tDCS (p ≤ 0.05). No significant differences were found in the cuff pressure pain detection/tolerance thresholds or CPM effect across the 3 days of HD-tDCS in any of the four groups. Conclusion: HD-tDCS reduced the facilitation of TSP caused by tonic pain suggesting that efficacy of HD-tDCS might depend on the presence of sensitized central pain mechanisms.

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Current Neurostimulation Therapies for Chronic Pain Conditions

Shlobin,

2023

Curr Pain Headache Rep

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The effect of high-definition transcranial direct current stimulation on pain processing in a healthy population: A single-blinded crossover controlled study

Cited by 10 publications

References 40 publications

Modulating the somatosensory system using high-definition transcranial direct current stimulation

Modulating the somatosensory system using high-definition transcranial direct current stimulation

Modulation of central pain mechanisms using high‐definition transcranial direct current stimulation: A double‐blind, sham‐controlled study

Current Neurostimulation Therapies for Chronic Pain Conditions

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