The effect of hibernation on the morphology and histochemistry of the intestine of the greater mouse-eared bat, Myotis myotis

Paksuz, Emine Pınar

doi:10.1016/j.acthis.2014.10.004

Cited by 10 publications

(6 citation statements)

References 57 publications

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“…The depth of the crypt in the colonic mucosa of the ground squirrels was reduced after entering hibernation, which may be due to the reduction of intestinal absorption and secretion functions, as a result of winter fasting. Significantly, other studies have obtained results consistent with the present study, e.g., the depths of crypts in the duodenum, jejunum, and ileum of hibernating greater mouse-eared bats ( Myotis myotis ) were significantly reduced compared to those of active bats [ 17 ]. The authors suggested that the reduction in the depth of crypt may lead to lower cell proliferation and migration rates, which may be a way to reduce the cost of maintaining the intestine while hibernating.…”

Section: Discussionsupporting

confidence: 91%

“…There are a few reports in the literature that the depth of the small intestinal crypts was significantly reduced in hibernating greater mouse-eared bats ( Myotis myotis ) compared with the active phase [ 17 ]. The small intestinal epithelium of European hamsters [ 2 ] and thirteen-lined ground squirrels [ 3 ] showed atrophy during food deprivation in hibernation.…”

Section: Introductionmentioning

confidence: 99%

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Dynamic Changes in Colonic Structure and Protein Expression Suggest Regulatory Mechanisms of Colonic Barrier Function in Torpor–Arousal Cycles of the Daurian Ground Squirrel

Miao

Han

Yang

et al. 2022

IJMS

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Background: Both pathological conditions and hibernation can affect the barrier function of small intestine mucosa. However, the effect of hibernation on the barrier function of colonic mucosa remains unclear. Methods: We investigated morphological changes in colonic mucosa, the concentrations of specific proteins and molecules, and the enzymatic activity of diamine oxidase (DAO), in serum and colonic tissue; the expression of tight junction proteins and mucin, and the changes in inflammatory, farnesoid X receptor (FXR)–small heterodimer partner (SHP), and apoptosis-related molecules that could play a role in gut permeability changes in Daurian ground squirrels in summer active (SA), late torpor (LT), and interbout arousal (IBA) periods. Results: The results show that hibernation reduced the thickness of the colonic mucosa and the depth of the crypt, decreased the number of goblet cells (GCs), and damaged the structure of some microvilli. The concentrations of proteins and molecules, and the enzymatic activity of DAO, were all increased in the serum and colon, and the localization of tight junction proteins and mucin in the colonic mucosa were altered (compensatory response). Although the ground squirrels ate during the interbout arousal period, the changes remained similar to the response to torpor. Inflammation, apoptosis–anti-apoptosis, and FXR–SHP signaling may be involved in the possible changes in intestinal gut permeability during the torpor–arousal cycle in Daurian ground squirrels. In addition, periodic interbout arousal may play an inflammation-correcting role during the long hibernation season of Daurian ground squirrels.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Dynamic Changes in Colonic Structure and Protein Expression Suggest Regulatory Mechanisms of Colonic Barrier Function in Torpor–Arousal Cycles of the Daurian Ground Squirrel

Miao

Han

Yang

et al. 2022

IJMS

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“…Several studies have been carried out related to histochemical characteristics of the digestive system of various mammalian species (Abdel‐Magied and Taha, 2003; Boonzaier et al., 2013; Kotze and Coetzee, 1994). However, reports on order Chiroptera are still scarce (Bhide, 1981; El‐Mansi et al., 2019; Perrin and Hughes, 1992; Rouk & Glass, 1970; Scillitani et al., 2007; Strobel et al., 2013; Paksuz, 2014).…”

Section: Discussionmentioning

confidence: 99%

Histomorphometric and histochemical characteristics of the oesophagus of the greater mouse‐eared Bat, Myotis myotis (Borkhausen, 1797)

Paksuz

2021

Anat Histol Embryol

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The aim of this study was to examine the histomorphometric and histochemical structure of oesophagus of the wild‐caught greater mouse‐eared bat M. myotis. For this purpose, 10 specimens of oesophagus were collected and processed. The oesophagus wall of M. myotis is composed of four layers: tunica mucosa, tunica submucosa, tunica muscularis and tunica adventitia. The mucosa is covered by a non‐keratinized stratified squamous epithelium. There were no glands in the wall of the oesophagus. Tunica muscularis is composed of two muscle layers: internal circular muscular layer and an external longitudinal muscular layer. Histochemical studies revealed that the oesophagus was AB/PAS and PAS positive indicating the presence of acidic and neutral mucosubstances. AB‐PAS staining shows that glycoproteins were predominant in the all examined layers of the oesophagus. Because of the absence of oesophageal glands in M. myotis, positive reaction with AB‐PAS staining may be due to secretion of salivary glands. Absence of oesophageal glands reflects the functional adaptation as high food passage rate for the insectivorous feeding habits of animals.

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“…Most of the studies related to the anatomy of Chiroptera focused on macroscopic structure of the skull and teeth (Abdel-Hamid & Alqahtani, 2022), wings (Ahmad et al, 2022), auditory organs (Tarnovsky et al, 2023), heart (Corduneanu et al, 2021;Rahma et al, 2021), digestion organs (Yani & Yuliyantika, 2019), specifically the oral cavity, tongue (Gregorin & Zanatta, 2021), gastrointernal tract (Selim & El Nahas, 2015;Strobel et al, 2015); and respiratory pathways (Smith et al, 2021;Håkansson et al, 2022). At the microscopic level, normal microstructure was stu-died for digestive organs (Paksuz, 2014;Silva et al, 2020), sexual apparatus (Danmaigoro et al, 2014;Jubilato et al, 2019;Abiaezute et al, 2020;Oguejiofor et al, 2020;Sohn et al, 2020), mostly of males, and also the skin (De Souza Suguiura et al, 2023). Some studies focused on structure of the lungs (Ojuolape et al, 2016), kidneys, and spleen.…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of histological structure of some organs of serotine bat (Eptesicus serotinus)

Serdioucov,

Filipets,

Shkundia

et al. 2023

Regul. Mech. Biosyst.

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Chiroptera is the only group of mammals that is able to fly. They are beneficial for people and ecosystem they live in. In Ukraine, all species of bats are rare or endangered, in particular serotine bat (Eptesicus serotinus Schreber, 1774). So as to prevent the extinction of currently existing species of bats, it is crucial to combat their diseases, in particular improve diagnostics, including postmortem diagnostics. At the macroscopic and microscopic levels, morphology of bats has still been studied poorly, especially such of bats that live in Ukraine. Besides, knowledge of the structure of various organs of bats at macroscopic and microscopic levels is necessary for effective pathoanatomic diagnostics of their diseases. We researched the normal histological structure of some organs of E. serotinus. For this purpose, we used four corpses of this animal, which had previously died as a result of their disturbance during winter hibernation. We carried out a histological study, for which we sampled organs such as the liver, kidneys, lungs, heart, subcutaneous gland, and spleen. From the samples, we prepared histological sections and stained them with hematoxylin eosin. We described the general patterns of microscopic structure of the said organs of serotine bat. We found that microscopic structure of all the examined organs was similar to that of mammals in general. At the same time, we did observe some peculiarities of the histological structure of the studied organs, especially lungs, compared with such of other mammals, particularly: poor degree of development of the stroma, compact arrangement of parenchyma elements in the parenchyma-structure organs, large variability of sizes of alveolar lumens in the lungs. We assume that those peculiarities had emerged because of bats’ adaptation for flight. We believe that it is promising to continue research of microscopic structure of various organs of E. serotinus, as well as other bats living in Ukraine and around the globe.

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The effect of hibernation on the morphology and histochemistry of the intestine of the greater mouse-eared bat, Myotis myotis

Cited by 10 publications

References 57 publications

Dynamic Changes in Colonic Structure and Protein Expression Suggest Regulatory Mechanisms of Colonic Barrier Function in Torpor–Arousal Cycles of the Daurian Ground Squirrel

Dynamic Changes in Colonic Structure and Protein Expression Suggest Regulatory Mechanisms of Colonic Barrier Function in Torpor–Arousal Cycles of the Daurian Ground Squirrel

Histomorphometric and histochemical characteristics of the oesophagus of the greater mouse‐eared Bat, Myotis myotis (Borkhausen, 1797)

Peculiarities of histological structure of some organs of serotine bat (Eptesicus serotinus)

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