The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review

Abstract

To cite this article: Int J Dent Hygiene 9, 2011; 182–190 DOI: 10.1111/j.1601‐5037.2010.00478.x Afennich F, Slot DE, Hossainian N, Van der Weijden GA. The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review. Abstract: Objective: To review the literature concerning hexetidine‐containing mouthwash as a monotherapy or as an adjunct to oral hygiene in the prevention of plaque accumulation and gingival inflammation. Materials and methods: PubMed‐MEDLINE and the Cochrane‐CENTRAL were searched through January 2010 to identify appropriate studies. The primary outcome measurements were plaque accumulation and gingivitis parameters. Results: Independent screening of titles and abstracts of 168 papers resulted in six publications that met the eligibility criteria. Mean values and standard deviations were obtained by data extraction. Descriptive comparisons are presented for hexetidine mouthwash and control mouthwashes (chlorhexidine and placebo). Conclusions: Considering the potential benefits in the light of the observed side effects, hexetidine appears to be a poor alternative to chlorhexidine.

Essential Oils Compared to Chlorhexidine With Respect to Plaque and Parameters of Gingival Inflammation: A Systematic Review

“…This review is part of a series of reviews 3,71,81‐85 that have addressed the efficacy of various chemical agents in oral health care products for patients with gingivitis. These include the use of stannous‐fluoride, essential oils, cetylpyridinium chloride (CPC), hexetidine, hydrogen peroxide (H 2 O 2 ), triclosan, and CHX.…”

Can Chemical Mouthwash Agents Achieve Plaque/Gingivitis Control?

“…23,24,26 Five studies compared active ingredients, of which 2 also contributed data for the singles active ingredients. 27,28 In one publication, a combination of 2 active ingredients was systematically evaluated. 29 …”

Evaluation of antimicrobial activity of orange peel extract against oral biofilm forming organisms: an in vitro microbial study and scanning electron microscopic assessment

“…The use of chemical plaque control agents to control plaque and gingivitis levels has been widely evaluated and efficacy for some formulations has been observed in different systematic reviews. [2][3][4][5][6][7][8][9][10] Out of a number of chemical plaque control agents available, chlorhexidine is considered as a gold standard. 11 Though it obeys many features of the ideal chemical agent for plaque control, there are many limitations regarding the safety of its usage over extended periods.…”