The effect of heritability and host genetics on the gut microbiota and metabolic syndrome

Lim, Mi Young; You, Hyun Ju; Yoon, Hye-Kyung; Kwon, Bomi; Lee, Jae Yoon; Lee, Sung‐Hee; Song, Yun-Mi; Lee, Kayoung; Sung, Joohon; Ko, GwangPyo

doi:10.1136/gutjnl-2015-311326

Cited by 295 publications

(254 citation statements)

References 58 publications

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“…It also positively correlated with alpha-diversity, which was higher in lean compared to obese subjects in the TwinsUK population. The association of Christensenellaceae with a lean phenotype was also observed in Missouri twins (64), the Dutch LifeLines- DEEP population (17), Koreans (40) and Japanese individuals (51). Christensenellaceae was subsequently linked to visceral fat phenotypes in the TwinsUK cohort (3), as well as with healthy levels of triglycerides in the Dutch LifeLines- DEEP cohort (17).…”

Section: Heritable Taxa Of the Human Gut Microbiome Are Increasingly mentioning

confidence: 75%

“…Subsequently, the heritability of Christensenellaceae has been validated in Canadians of European descent (0.64) and in Koreans (0.31; Figure 1) (40, 65). Christensenellaceae is a family within Firmicutes that is relatively small (i.e., less branch length compared to a family such as the Ruminococcaceae), which might explain why the whole family is heritable.…”

Section: Heritable Taxa Of the Human Gut Microbiome Are Increasingly mentioning

confidence: 99%

“…Alpha-diversity is commonly negatively associated with several chronic inflammatory diseases such as inflammatory bowel disease (IBD) and obesity (48). For example, alpha-diversity (assessed from 16S rRNA gene diversity analysis of fecal samples) has been observed to be lower in patients with Metabolic syndrome compared to controls (38, 40). The reasons why microbiomes exhibit lower alpha-diversity may differ between disease states.…”

Section: Heritable Taxa Of the Human Gut Microbiome Are Increasingly mentioning

confidence: 99%

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The Relationship Between the Human Genome and Microbiome Comes into View

et al. 2017

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The microbiome’s involvement in health and disease, and the complexity of its composition and function, make it intriguing to consider human genetic factors that impact microbiome composition. Genes may influence health through their ability to promote a stable microbial community in the gut. Studies of heritability yield a consistent subset of microbes that are impacted by genes, but the use of genome-wide association studies (GWAS) to identify specific genetic variants associated with microbiota phenotypes has proven challenging. Processing microbiome datasets into traits to be modeled and reducing the burden of multiple testing are just some of the technical hurdles in microbiome GWAS. Studies to date are small by GWAS standards, making cross-study comparisons and validations particularly important in identifying authentic signals. Cross-study comparisons are hampered by differences in analytical approaches. Nevertheless, some consistent associations have emerged between populations, most notably between Bifidobacteria and the lactase non-persister genotype. These early successes open the way for the microbiome to be incorporated into studies that quantify interactions among genotype, environment, and the microbiome for predicting disease susceptibility.

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Section: Heritable Taxa Of the Human Gut Microbiome Are Increasingly mentioning

confidence: 75%

Section: Heritable Taxa Of the Human Gut Microbiome Are Increasingly mentioning

confidence: 99%

Section: Heritable Taxa Of the Human Gut Microbiome Are Increasingly mentioning

confidence: 99%

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The Relationship Between the Human Genome and Microbiome Comes into View

et al. 2017

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“…Furthermore, Sutterella spp. have been associated with autism, Down syndrome, and metabolic syndrome (Williams et al, 2012; Wang et al, 2013; Biagi et al, 2014; Lim et al, 2016). Half of the children with autism and GI dysfunction were Sutterella -positive with a predominance of either S. wadsworthensis or S. stercoricanis , whereas these species were not detected in the control group with only GI dysfunction (Williams et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Mucosal Prevalence and Interactions with the Epithelium Indicate Commensalism of Sutterella spp.

et al. 2016

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Sutterella species have been frequently associated with human diseases, such as autism, Down syndrome, and inflammatory bowel disease (IBD), but the impact of these bacteria on health still remains unclear. Especially the interactions of Sutterella spp. with the host are largely unknown, despite of the species being highly prevalent. In this study, we addressed the interaction of three known species of Sutterella with the intestinal epithelium and examined their adhesion properties, the effect on intestinal barrier function and the pro-inflammatory capacity in vitro. We also studied the relative abundance and prevalence of the genus Sutterella and Sutterella wadsworthensis in intestinal biopsies of healthy individuals and patients with celiac disease (CeD) or IBD. Our results show that Sutterella spp. are abundant in the duodenum of healthy adults with a decreasing gradient toward the colon. No difference was detected in the prevalence of Sutterella between the pediatric IBD or CeD patients and the healthy controls. Sutterella parvirubra adhered better than the two other Sutterella spp. to differentiated Caco-2 cells and was capable of decreasing the adherence of S. wadsworthensis, which preferably bound to mucus and human extracellular matrix proteins. Furthermore, only S. wadsworthensis induced an interleukin-8 production in enterocytes, which could be due to different lipopolysaccharide structures between the species. However, its pro-inflammatory activity was modest as compared to non-pathogenic Escherichia coli. Sutterella spp. had no effect on the enterocyte monolayer integrity in vitro. Our findings indicate that the members of genus Sutterella are widely prevalent commensals with mild pro-inflammatory capacity in the human gastrointestinal tract and do not contribute significantly to the disrupted epithelial homeostasis associated with microbiota dysbiosis and increase of Proteobacteria. The ability of Sutterella spp. to adhere to intestinal epithelial cells indicate that they may have an immunomodulatory role.

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“…Based on twin studies,5 it is understood that a core subset of bacteria are hereditary 6. However, environmental factors are thought to contribute more heavily to the composition of the gut microbiome.…”

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confidence: 99%

Routine assessment of the gut microbiome to promote preclinical research reproducibility and transparency

Wardill

Bowen

Sebille

et al. 2017

Gut

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The effect of heritability and host genetics on the gut microbiota and metabolic syndrome

Abstract: Our results suggest that an altered microbiota composition mediated by a specific host genotype can contribute to the development of MetS.

Cited by 295 publications

References 58 publications

The Relationship Between the Human Genome and Microbiome Comes into View

The Relationship Between the Human Genome and Microbiome Comes into View

Mucosal Prevalence and Interactions with the Epithelium Indicate Commensalism of Sutterella spp.

Routine assessment of the gut microbiome to promote preclinical research reproducibility and transparency

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