The Effect of Herbal Supplements on Blood Pressure: Systematic Review and Meta-Analysis

Lipert, Anna; Szadkowska, Iwona; Matusiak-Wieczorek, Ewelina; Kochan, Ewa

doi:10.3390/antiox11081419

Cited by 9 publications

(3 citation statements)

References 54 publications

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“…Bergamot reduces hunger sensations and has a strong effect on insulin sensitivity, lipid metabolism, and glucose tolerance. The positive influence of bergamot on cardiovascular health is well documented, mostly due to its anti-inflammatory properties that protect the vascular endothelium from ROS (129). The bergamot essential oil nonvolatile fraction (BEO-NVF) has been shown to possess significant antioxidant properties; thus, it is considered promising to prevent endothelial dysfunction, proliferation of smooth muscle cells, and inflammation.…”

Section: Citrus Bergamia (Risso Et Poiteau)mentioning

confidence: 99%

The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension

Caminiti,

Carresi,

Mollace

et al. 2024

Front. Cardiovasc. Med.

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Arterial hypertension represents a leading cause of cardiovascular morbidity and mortality worldwide, and the identification of effective solutions for treating the early stages of elevated blood pressure (BP) is still a relevant issue for cardiovascular risk prevention. The pathophysiological basis for the occurrence of elevated BP and the onset of arterial hypertension have been widely studied in recent years. In addition, consistent progress in the development of novel, powerful, antihypertensive drugs and their appropriate applications in controlling BP have increased our potential for successfully managing disease states characterized by abnormal blood pressure. However, the mechanisms responsible for the disruption of endogenous mechanisms contributing to the maintenance of BP within a normal range are yet to be fully clarified. Recently, evidence has shown that several natural antioxidants containing active ingredients originating from natural plant extracts, used alone or in combination, may represent a valid solution for counteracting the development of arterial hypertension. In particular, there is evidence to show that natural antioxidants may enhance the viability of endothelial cells undergoing oxidative damage, an effect that could play a crucial role in the pathophysiological events accompanying the early stages of arterial hypertension. The present review aims to reassess the role of oxidative stress on endothelial dysfunction in the onset and progression of arterial hypertension and that of natural antioxidants in covering several unmet needs in the treatment of such diseases.

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Section: Citrus Bergamia (Risso Et Poiteau)mentioning

confidence: 99%

The potential effect of natural antioxidants on endothelial dysfunction associated with arterial hypertension

Caminiti,

Carresi,

Mollace

et al. 2024

Front. Cardiovasc. Med.

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“…Out of several other herbal supplements (beetroot juice, bergamot extracts, barberry, pycnogenol), RSV represents a phenolic compound with proven blood-pressure (BP) lowering effects, which is recommended to be included in the nutrition of people with hypertension [31]. However, its appropriate dosage is still debatable [32]. A positive association between systolic-BP lowering RSV activity and body-mass index (BMI) at the baseline has been shown especially when used at a high dose (≥300 mg/day) and in diabetic patients [33].…”

Section: Resveratrol Gut Microbiota and Cardiovascular Diseasesmentioning

confidence: 99%

Resveratrol and Gut Microbiota Synergy: Preventive and Therapeutic Effects

Gostimirovic,

Rajkovic,

Bukarica

et al. 2023

IJMS

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The role of an imbalanced high-fat diet in the pathophysiology of common chronic noncommunicable diseases has been known for years. More recently, the concept of ‘gut microbiota’ and the interaction between their composition and gut metabolites produced from the intake of dietary products have gained the focus of researchers, mostly from the perspective of the prevention of cardiovascular and metabolic disorders, which are still the leading cause of death globally. The aim of this work is to highlight the health benefits of the interaction between resveratrol (RSV), red grape polyphenol, and gut microbiota, through aspects of their therapeutic and preventive potentials. Since changed microbiota (mostly as a consequence of antibiotic overuse) contribute to the persistence of post (‘long’)-COVID-19 symptoms, these aspects will be covered too. Data were obtained from the electronic databases (MedLine/PubMed), according to specific keywords regarding the protective role of resveratrol, the gut microbiota, and their synergy. RSV exerts beneficial properties in the modulation of cardiovascular, metabolic, and post-COVID-19-related disorders. In healthy individuals, it maintains an ergogenic capacity, prevents oxidative stress, and modulates the inflammatory response. Overall, it improves quality of life. The RSV–gut-microbiota interaction is beneficial in terms of maintaining human health. Along with physical activity, it is key for the prevention of chronic noncommunicable diseases.

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“…Blood pressure can be significantly reduced by the appropriate intake of several herbal supplements. A meta-analysis of 31 studies performed by Lipert et al [ 9 ] demonstrated that resveratrol, cherry and beetroot juice, bergamot extracts, barberry, and pycnogenol significantly lowered both systolic and diastolic blood pressure compared with a placebo. Therefore, the consumption of the abovementioned nutrients and food items can be considered part of a successful antihypertensive strategy and cardioprotection.…”

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confidence: 99%