The Effect of Hematocrit and Nanoparticles Diameter on Hemodynamic Parameters and Drug Delivery in Abdominal Aortic Aneurysm with Consideration of Blood Pulsatile Flow

Jafarzadeh, Sina; Sadr, Arsalan Nasiri; Kaffash, Ehsan; Goudarzi, Sahar; Golab, Ehsan; Karimipour, Arash

doi:10.1016/j.cmpb.2020.105545

Cited by 30 publications

(12 citation statements)

References 64 publications

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“…Their analysis showed (Gentile et al 2008 ) that rheology plays a decisive role in the transport of particles in the vascular network. More recently, Jafarzadeh et al ( 2020 ) studied the accumulation of particles once they are injected into an abdominal aortic aneurysm for the duration of a cardiac cycle under the imposition of a pulsatile bloodstream. They considered blood to behave as a shear-thinning fluid (by using the phenomenological model proposed by Ameenuddin et al ( 2019 ) according to which the shear viscosity depends on both the shear rate and the hematocrit) to study the hemodynamical flow in the vicinity of an abdominal aortic aneurysm.…”

Section: Introductionmentioning

confidence: 99%

Elucidating the rheological implications of adding particles in blood

Stephanou

2021

Rheol Acta

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Graphical abstract In the past few decades, nanotechnology has been employed to provide breakthroughs in the diagnosis and treatment of several diseases using drug-carrying particles (DCPs). In such an endeavor, the optimal design of DCPs is paramount, which necessitates the use of an accurate and trustworthy constitutive model in computational fluid dynamics (CFD) simulators. We herein introduce a continuum model for elaborating on the rheological implications of adding particles in blood. The model is developed using non-equilibrium thermodynamics to guarantee thermodynamic admissibility. Red blood cells are modeled as deformed droplets with a constant volume that are able to aggregate, whereas particles are considered rigid spheroids. The model predictions are compared favorably against rheological data for both spherical and non-spherical particles immersed in non-aggregating blood. It is expected that the use of this model will allow for the testing of DCPs in virtual patients and for their tailor-design in treating various diseases. Supplementary Information The online version contains supplementary material available at 10.1007/s00397-021-01289-x.

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Section: Introductionmentioning

confidence: 99%

Elucidating the rheological implications of adding particles in blood

Stephanou

2021

Rheol Acta

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“…10. Besides, by increasing the Hematocrit, the dynamic viscosity of blood increases [51], and according to equation ( 5), the microvascular resistance increases. All of the aforementioned factors lead to a decrease in the blood flow rate by increasing the Hematocrit.…”

Section: Discussionmentioning

confidence: 99%

A validated reduced-order dynamic model of nitric oxide regulation in coronary arteries

Moshfegh

Tajeddini

Pakravan

et al. 2021

Computers in Biology and Medicine

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“…Several numerical studies show that, compared to reconstructed geometries from medical imaging, virtual aneurysm models are more useful for parametrical studies [16,17]. The use of idealized geometry was adopted in many studies concerning AAA and other cardiovascular diseases [15][16][17][18][19][20][21][22]. The models do not preserve the physiologically correct geometry, but they still retain important physical processes that occur in an AAA [23].…”

Section: Introductionmentioning

confidence: 99%

Flow Behaviour and Wall Shear Stress Derivatives in Abdominal Aortic Aneurysm Models: A Detailed CFD Analysis into Asymmetry Effect

Belkacemi

AL-Rawi²,

Abbès³

et al. 2022

CFDL

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Assessing the risk of rupture is extremely important to reduce the mortality of the abdominal aortic aneurysm (AAA). Current clinical guidelines suggest considering the maximum diameter as a criterion for planning and surgical intervention; however, this approach is too simplistic and overlooks other morphological parameters that are associated with the risk of rupture. The aim of this paper is to study the thrombogenicity and to predict the risk of AAA rupture by taking into consideration the geometrical asymmetry of the aneurysm, studying its effect on blood flow behaviour and vortical structure, spatiotemporal distribution of wall shear stresses (WSS), and their related parameters. To show the effect of asymmetry on blood flow dynamics and hemodynamic forces, five virtual models were constructed using five values of geometrical asymmetry ratio β ranging from β=0.2 (asymmetric model; AM) to β=1 (symmetric model; SM). Simulations were run for each geometry under transient physiological flow conditions using finite volume discretization. Resting flow rate was investigated in these models and our results demonstrate that the asymmetry of the aneurysm has a clear effect on the flow behaviour, and consequently on WSS distribution, oscillatory shear index (OSI) and time averaged wall shear stress (TAWSS). Furthermore, these preliminary findings suggest that thrombus formation and rupture risk are more probable in an asymmetric abdominal aortic aneurysm.

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The Effect of Hematocrit and Nanoparticles Diameter on Hemodynamic Parameters and Drug Delivery in Abdominal Aortic Aneurysm with Consideration of Blood Pulsatile Flow

Cited by 30 publications

References 64 publications

Elucidating the rheological implications of adding particles in blood

Elucidating the rheological implications of adding particles in blood

A validated reduced-order dynamic model of nitric oxide regulation in coronary arteries

Flow Behaviour and Wall Shear Stress Derivatives in Abdominal Aortic Aneurysm Models: A Detailed CFD Analysis into Asymmetry Effect

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