The effect of Helicobacter pylori eradication on liver enzymes in patients referring with unexplained hypertransaminasemia

Hassan, Sameer; Minakari, Mohammad; Yaghoutkar, Arezoo; Tabesh, Elham; Salehi, Mohammad; Mirbagher, Leila

doi:10.4103/2277-9175.133256

Cited by 16 publications

(7 citation statements)

References 22 publications

(30 reference statements)

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“…Studies performed among patients with chronic viral autoimmune and toxic hepatitis and coexisting H. pylori infection demonstrated improvement in liver function, including decreased ALT and AST activity, after effective eradication of bacteria [26].…”

Section: Autoimmune Diseases and Liver Steatosismentioning

confidence: 99%

The Importance of H. pylori Infection in Liver Diseases

Łapiński¹

2018

Helicobacter Pylori [Working Title]

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The chapter is a review of current knowledge on the impact of H. pylori infection on the clinical course of patients with various forms of liver damage. H. pylori infection is found in 50-90% of the world population. The bacteria not only mainly contribute to occurrence of gastric mucosa inflammation but also to gastric ulcer and cancer. H. pylori contains an active antioxidative system, which not only neutralizes free radicals but also synthesizes specific VacA toxin, which leads to destruction and apoptosis of the cells. A specific system of bacterial CagA genes has a special role in carcinogenesis. There is an increasing number of reports describing lesions in the circulatory system, pancreas, or the skin, connected with H. pylori infection. Liver colonization by H. pylori happens after transmission of the bacteria from the stomach, with blood, through the portal vein or directly through the bile ducts. The bacteria promote liver function deterioration in the course of toxic injury, autoimmune inflammation, chronic HBV, and HCV infection. Infections among people with liver cirrhosis are especially dangerous. In this group of patients, H. pylori infection may significantly worsen liver function, leading to hyperammonemia, increased portal pressure, and development of esophageal varices. Thus, testing for and treating this infection among patients with liver cirrhosis is especially important.

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Section: Autoimmune Diseases and Liver Steatosismentioning

confidence: 99%

The Importance of H. pylori Infection in Liver Diseases

Łapiński¹

2018

Helicobacter Pylori [Working Title]

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“…14,15 There is a relationship between H. pylori bacterial infection and aminotransferase activity, liver cirrhosis, and hepatitis C virus (HCV) infection because they co-promote hepatic fibrosis and promote co-infection. [16][17][18][19] H. pylori also maybe has a role in hepatic cancer as a co-infection with HBV. Recently, hepatitis B virus (HBV) Ag was detected in the gastric mucosa of patients infected with H. pylori.…”

Section: Introductionmentioning

confidence: 99%

H. pylori Infection and Hepatitis and Its Functional Abnormality in Ninawa Governorate Population, Iraq

Mohammed,

Salman,

Hasan

et al. 2024

European Journal of Oncology Pharmacy

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The external gastric effect of H. pylori is not restricted to the liver. In this study, we will detect this fact through the effect of this bacterial infection on the normal physiological function of the liver. The passive negative effect of Helicobacter on the liver is reflected as hepatitis. Hepatitis causes alteration in the normal physiological function of the liver on different levels, starting from the normal enzyme secretion level to the hormonal level, which is secreted by the liver to regulate the normal function of other systems. The aim of this study was to find this fact by comparing some parameters from the patient (with gastric ulcer) with those of a normal noninfected individual. The parameter is icterus in the patient as a clinical sign that reflected hepatic abnormality and hepatitis detected by a highly skilled clinician. A recent study with a case-control design connected hepatitis and its functional abnormalities in a patient with gastric ulcer who was infected by H. pylori. A total of 382 patients were included as the sample from a community of 60,000 patients in a specific area of Mosul, Iraq. The total population of this city is around 1.5 million. According to a previous study, it is estimated that 0.02% of the city population suffers from gastric ulcers caused by H. pylori. The sample was collected by highly skilled staff along with specialist clinicians. The data were analyzed using SPSS 25 by the specialized staff. We monitored the negative effect of H. pylori on different aspects of infected patients, especially hepatic inflammation and its abnormal physiological function. In this study, icterus is used as a clinical indicator for hepatic abnormalities.

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“…However, only a tiny fraction of infected individuals develop ITP-HP [ 11 ]. Platelet response to documented bacterial eradication varies across studies, ranging from 0% to 7% in the US series and up to 100% in the Japanese series [ 10 - 12 ]. Successful bacterial eradication has been shown to provide benefits compared to unsuccessful or no eradication [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Platelet response to documented bacterial eradication varies across studies, ranging from 0% to 7% in the US series and up to 100% in the Japanese series [ 10 - 12 ]. Successful bacterial eradication has been shown to provide benefits compared to unsuccessful or no eradication [ 12 , 13 ]. Failure to correct thrombocytopenia in some cases is associated with the emergence of antigen-independent autoreactive clones of T and B cells [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Immune Thrombocytopenic Purpura Associated With Systemic Lupus Erythematosus, Helicobacter pylori, and Hepatitis B

Johnson,

Nimawat,

Doar

et al. 2024

Cureus

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Immune thrombocytopenic purpura (ITP) is a hematologic condition characterized by decreased circulating platelets, resulting in bruising, bleeding gums, and internal bleeding. This disorder can be categorized into two primary forms based on the duration of symptoms and underlying causes. Acute ITP primarily affects young children, typically between the ages of two and six, but it can also impact older children and adults. Viral infections like chickenpox, respiratory infections, or gastroenteritis often precede it. Acute ITP manifests suddenly and lasts for a short period, typically less than six months and sometimes only a few weeks. On the other hand, chronic ITP primarily affects adults but can occur at any age, including childhood and adolescence. The main characteristic of chronic ITP is the persistence of symptoms for more than six months. It can be either idiopathic (primary), with no discernible etiologic cause, or secondary to various conditions such as autoimmune diseases (e.g., systemic lupus erythematosus), viral infections (e.g., human immunodeficiency virus (HIV), hepatitis C virus (HCV)), certain malignancies (e.g., chronic lymphocytic leukemia), or drug reactions. This case report presents the management of a 36-year-old African American female diagnosed with ITP associated with systemic lupus erythematosus, Helicobacter (H.) pylori, and hepatitis B infection.

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The effect of Helicobacter pylori eradication on liver enzymes in patients referring with unexplained hypertransaminasemia

Cited by 16 publications

References 22 publications

The Importance of H. pylori Infection in Liver Diseases

The Importance of H. pylori Infection in Liver Diseases

H. pylori Infection and Hepatitis and Its Functional Abnormality in Ninawa Governorate Population, Iraq

Immune Thrombocytopenic Purpura Associated With Systemic Lupus Erythematosus, Helicobacter pylori, and Hepatitis B

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