The Effect of Helicobacter Pylori and Economic Status on Growth Parameters and Leptin, Ghrelin, and Insulin-Like Growth Factor (IGF)-I Concentrations in Children

Ozen, Ahmet; Furman, Andrzej; Berber, Mustafa; Karatepe, Hande Özgün; Mutlu, Nilgün; Sarıçoban, Hülya Ercan; Büyükgebiz, Benal

doi:10.1111/j.1523-5378.2010.00814.x

Cited by 34 publications

(41 citation statements)

References 67 publications

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“…Thus some researchers imply that the association of H. pylori infection and malnutrition is not a cause-effect relation but, rather, a co-existence of these entities in poor living conditions. [39].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection in Children: Nutritional Status and Associations with Serum Leptin, Ghrelin, and IGF‐1 Levels

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection in Children: Nutritional Status and Associations with Serum Leptin, Ghrelin, and IGF‐1 Levels

et al. 2015

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“…For instance, H. pylori has been reported to confer protective effects against esophageal cancer (Islami & Kamangar 2008), but on the other hand, together with hepatitis B and C viruses, and human papillomaviruses, the bacterium is responsible for about a third of all cancers attributable to infections, mainly including gastric, liver, and cervix uteri cancers (de Martel et al 2012, Sakitani et al 2012. In addition, silent infection with H. pylori is a source of pro-inflammatory cytokines and IGF1 in hyperinsulinemia conditions (Aguilera et al 2004, Ozen et al 2011. Unraveling the precise role of ILP molecules in H. pylori-related carcinogenesis may provide novel pharmacological targets for microorganism-related cancers.…”

Section: Insulin Resistance Infection and Cancermentioning

confidence: 99%

Insulin resistance and cancer: the role of insulin and IGFs

Djiogue¹,

Kamdje²,

Vecchio³

et al. 2012

Endocrine-Related Cancer

229

188

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Insulin, IGF1, and IGF2 are the most studied insulin-like peptides (ILPs). These are evolutionary conserved factors well known as key regulators of energy metabolism and growth, with crucial roles in insulin resistance-related metabolic disorders such as obesity, diseases like type 2 diabetes mellitus, as well as associated immune deregulations. A growing body of evidence suggests that insulin and IGF1 receptors mediate their effects on regulating cell proliferation, differentiation, apoptosis, glucose transport, and energy metabolism by signaling downstream through insulin receptor substrate molecules and thus play a pivotal role in cell fate determination. Despite the emerging evidence from epidemiological studies on the possible relationship between insulin resistance and cancer, our understanding on the cellular and molecular mechanisms that might account for this relationship remains incompletely understood. The involvement of IGFs in carcinogenesis is attributed to their role in linking high energy intake, increased cell proliferation, and suppression of apoptosis to cancer risks, which has been proposed as the key mechanism bridging insulin resistance and cancer. The present review summarizes and discusses evidence highlighting recent advances in our understanding on the role of ILPs as the link between insulin resistance and cancer and between immune deregulation and cancer in obesity, as well as those areas where there remains a paucity of data. It is anticipated that issues discussed in this paper will also recover new therapeutic targets that can assist in diagnostic screening and novel approaches to controlling tumor development.

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“…H. pylori infection is associated with growth failure and possibly lower ghrelin levels (10). On the other hand, the likelihood of the association between H. pylori and growth failure still remains controversial (11)(12)(13)(14)(15)(16)(17). Some researchers assert that the association of H. pylori infection and growth failure is not a cause-effect relation, but rather, a coincidence of these two entities in low socioeconomic conditions (19).…”

Section: Discussionmentioning

confidence: 96%

“…Potential relationships between gastrointestinal disease associated with H. pylori, and ghrelin, growth and appetite still remain unclear, because other factors like socioeconomic status may also be involved (10)(11)(12).…”

Section: Ghrelinmentioning

confidence: 97%

The Effect of Helicobacter Pylori Infection on Plasma Ghrelin and on AnthropometrY Dyspeptic Children

Kocaoğlu¹

2014

Acta Endo (Buc)

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Background. Plasma level of ghrelin is possibly reduced in Helicobacter pylori infection and may account for the resultant failure to thrive. Objective.To investigate relationships between Helicobacter pylori infection, and plasma level of ghrelin, anthropometric measurements, appetite, educational and economical status of parents.Methods. Ninety-four children were screened for Helicobacter pylori infection with C-14 urea breath test. Anthropometric measurements were performed in Helicobacter pylori (+) and (-) groups. Plasma ghrelin was measured.Parents were asked to fill out the questionnaire prepared by the researcher on the number of family members, parents' level of education, monthly income and children's status for appetite.Results. Plasma ghrelin was lower in Helicobacter pylori (+) group (20.00 ± 22.10 ng/mL), compared to Helicobacter pylori (-) group (79.72 ± 78.13 ng/mL).The percentiles of measurements for height, weight and body mass index were higher in Helicobacter pylori (-) group. Results of C-14 urea breath test were negatively correlated with height, weight and body mass index; however, no correlation was detected between the results of C-14 urea breath test, and plasma ghrelin, number of family members, levels of parents' education and income. A negative correlation was observed between the results of C-14 urea breath test and appetite.Conclusions. Helicobacter pylori infection is considered to play a restricting role in growth potential by decreasing ghrelin level in children. Moreover, the existence of a negative correlation between the results of C-14 UBT, and weight, height and body mass index suggests a possible link between Helicobacter pylori infection and poor growth.

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The Effect of Helicobacter Pylori and Economic Status on Growth Parameters and Leptin, Ghrelin, and Insulin-Like Growth Factor (IGF)-I Concentrations in Children

Abstract: We suggest that H. pylori may impair growth significantly only in susceptible children where unfavorable socioeconomic conditions facilitate its action, probably through mechanisms, at least in part, involving growth-related molecules.

Cited by 34 publications

References 67 publications

Helicobacter pylori Infection in Children: Nutritional Status and Associations with Serum Leptin, Ghrelin, and IGF‐1 Levels

Helicobacter pylori Infection in Children: Nutritional Status and Associations with Serum Leptin, Ghrelin, and IGF‐1 Levels

Insulin resistance and cancer: the role of insulin and IGFs

The Effect of Helicobacter Pylori Infection on Plasma Ghrelin and on AnthropometrY Dyspeptic Children

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