The effect of gut microbiota and probiotic organisms on the properties of extended spectrum beta-lactamase producing and carbapenem resistant Enterobacteriaceae including growth, beta-lactamase activity and gene transmissibility

Kunishima, Hiroyuki; Ishibashi, Noriomi; Wada, Koichiro; Oka, Koichiro; Takahashi, Motomichi; Yamasaki, Yukitaka; Aoyagi, Tetsuji; Takemura, Hiromu; Kitagawa, Miho; Kaku, Mitsuo

doi:10.1016/j.jiac.2019.04.021

Cited by 16 publications

(14 citation statements)

References 28 publications

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“…Likewise, the microbiota composition in hospitalized patients was shown to impact the susceptibility to colonization with multidrug resistant bacteria, and the use of probiotic strains such as L. plantarum or L. fermentum was associated with a reduction in colonization with naturally resistant pathogens, such as Acinetobacter baumannii, Pseudomonas aeruginosa, or Candida albicans (Singhi and Kumar, 2016;Soltan Dallal et al, 2017). In vitro, culture supernatants of Clostridium butyricum, C. difficile, Clostridium perfringens, Enterococcus faecium, and L. plantarum suppressed the growth and gene resistance transmission of ESBL-carrying bacteria and CPE (Kunishima et al, 2019).…”

Section: Probiotic Eradication Of Antibiotic Resistancementioning

confidence: 99%

How Probiotics Affect the Microbiota

Wieërs

Belkhir

Enaud

et al. 2020

Front. Cell. Infect. Microbiol.

344

205

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Probiotics have been used to treat a variety of diseases for decades; however, what is the rationale for their application? Such a treatment was first proposed in the early nineteenth century based on observations of decreased bifidobacterial populations in children suffering from diarrhea, suggesting that oral intake of bifidobacteria could replete this subpopulation of the microbiota and improve health. Since then, studies have shown modifications in the gut or skin microbiota in the course of a variety of diseases and suggested positive effects of certain probiotics. Most studies failed to report any impact on the microbiota. The impact of probiotics as well as of bacteria colonizing food does not reside in their ability to graft in the microbiota but rather in sharing genes and metabolites, supporting challenged microbiota, and directly influencing epithelial and immune cells. Such observations argue that probiotics could be associated with conventional drugs for insulin resistance, infectious diseases, inflammatory diseases, and psychiatric disorders and could also interfere with drug metabolism. Nevertheless, in the context of a plethora of probiotic strains and associations produced in conditions that do not allow direct comparisons, it remains difficult to know whether a patient would benefit from taking a particular probiotic. In other words, although several mechanisms are observed when studying a single probiotic strain, not all individual strains are expected to share the same effects. To clarify the role of probiotics in the clinic, we explored the relation between probiotics and the gut and skin microbiota.

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Section: Probiotic Eradication Of Antibiotic Resistancementioning

confidence: 99%

How Probiotics Affect the Microbiota

Wieërs

Belkhir

Enaud

et al. 2020

Front. Cell. Infect. Microbiol.

344

205

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“…The preincubation of CBM 588 with Caco-2 cells inhibited the establishment of EHEC [87] (Figure 3). Kunishima et al [88] investigated the effects of CBM 588 on the growth, β-lactamase activity, and transmissibility of the antibiotic resistance properties of antimicrobial-resistant (AMR) organisms, including extended-spectrum β-lactamase (ESBL)-producing E. coli and carbapenem-resistant Enterobacterales. Consequently, the growth of AMR bacteria was inhibited in a dose-dependent manner by the supernatants of Clostridium spp.…”

Section: Escherichia Coli Infectionmentioning

confidence: 99%

“…In vitro studies revealed that the co-culture of CBM 588 and EHEC inhibited the growth of EHEC and reduced their toxin production [ 88 ]. Butyrate was found to be involved in these inhibitory effects, and caused pH-independent and dose-dependent antibacterial effects on EHEC.…”

Section: Bacterial Gastrointestinal Infectionsmentioning

confidence: 99%

Effect of Clostridium butyricum on Gastrointestinal Infections

et al. 2022

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Clostridium butyricum is a human commensal bacterium with beneficial effects including butyrate production, spore formation, increasing levels of beneficial bacteria, and inhibition of pathogenic bacteria. Owing to its preventive and ameliorative effects on gastrointestinal infections, C. butyricum MIYAIRI 588 (CBM 588) has been used as a probiotic in clinical and veterinary medicine for decades. This review summarizes the effects of C. butyricum, including CBM 588, on bacterial gastrointestinal infections. Further, the characteristics of the causative bacteria, examples of clinical and veterinary use, and mechanisms exploited in basic research are presented. C. butyricum is widely effective against Clostoridioides difficile, the causative pathogen of nosocomial infections; Helicobacter pylori, the causative pathogen of gastric cancer; and antibiotic-resistant Escherichia coli. Accordingly, its mechanism is gradually being elucidated. As C. butyricum is effective against gastrointestinal infections caused by antibiotics-induced dysbiosis, it can inhibit the transmission of antibiotic-resistant genes and maintain homeostasis of the gut microbiome. Altogether, C. butyricum is expected to be one of the antimicrobial-resistance (AMR) countermeasures for the One-health approach.

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“…Overlap of resistance genes identified from the human microbiomes of two healthy unrelated individuals. resistance genes from two individuals are compared to each other and defined as being shared if they have greater than 90% sequence identity at the nucleotide level [46]. These resistance genes identified using meta-genomic functional selections are shared between two individuals to a much lesser extent than resistance genes identified from cultured gut isolates (see Figure 5 bottom).…”

Section: The Human Microbiome As a Reservoir For Antimicrobial Resistance Genesmentioning

confidence: 99%

A Novel Computer-Aid Nanotechnology Targeting to Combat Antibiotics Resistance with Superbugs against COVID-19 Pandemic

Kim¹

2021

ABEB

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Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. During COVID-19 pandemic outbreak antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Thus, a novel technological approach on improving existing drugs is gaining special interest. Based on nano-medicine performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria. Hence, the scientific community should also pay attention to developing affordable methodologies so that nanotechnology can reach patients.

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The effect of gut microbiota and probiotic organisms on the properties of extended spectrum beta-lactamase producing and carbapenem resistant Enterobacteriaceae including growth, beta-lactamase activity and gene transmissibility

Cited by 16 publications

References 28 publications

How Probiotics Affect the Microbiota

How Probiotics Affect the Microbiota

Effect of Clostridium butyricum on Gastrointestinal Infections

A Novel Computer-Aid Nanotechnology Targeting to Combat Antibiotics Resistance with Superbugs against COVID-19 Pandemic

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