The effect of Guarana (Paullinia cupana) on metabolic and inflammatory parameters in adult male mice programmed by maternal obesity

Lima, Natália da Silva; Caria, Cíntia Rabelo e Paiva; Gambero, Alessandra; Ribeiro, Marcelo Lima

doi:10.1007/s00394-018-1686-1

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…The potential of guarana to improve growth and health has also been reported in other studies, as it has antioxidant, immunomodulatory, anticancer properties and a low cytotoxic effect (Lima et al, 2018;Marques et al, 2019;Kaushik et al, 2020;Junior et al, 2020). It also has antimicrobial properties against the bacteria Escherichia coli, Staphylococcus epidermidis, Staphylococcus aureus and methicillinresistant Staphylococcus aureus, which were proven in different guarana seed extracts by Carvalho et al (2016), and by Junior et al (2020) against Pseudomonas aeruginosa, E. coli and Candida albicans.…”

Section: Introductionmentioning

confidence: 60%

Dietary guarana (Paullinia cupana) powder for tambaqui (Colossoma macropomum): growth, hemato-immunological parameters and bacterial challenge

Moreira

Fernandes

et al. 2022

Preprint

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The present study evaluated the effects of commercial guarana (Paullinia cupana) powder as a growth-promoter and natural antioxidant supplement in aquafeeds. In Experiment 1, fish were fed with graded levels of guarana powder (0, 1.25, 2.5, 5 and 10 g/kg) during 60 days. Growth, hemato-immunological and biochemical performance were evaluated in healthy fish and in fish after infection by Aeromonas jandaei. In Experiment 2, the supplemented feed was stored for 90 days, in which tests were carried out regarding the quantity of phenolic compounds and the inhibition of lipid peroxidation. As a result of Experiment 1, fish fed guarana-supplemented diets and infected by A. jandaei presented better parameters of leukocyte respiratory activity, total proteins, globulin, albumin, alanine aminotransferase (ALT), leukocytes, lymphocytes, neutrophils, monocytes and thrombocytes. As a result of Experiment 2, levels of phenolic compounds were not altered (p > 0.05) by the guarana-supplemented diets. An increase in the concentration of malondialdehyde (MDA) and a lower oxygen radical absorbance capacity (ORAC) was observed in the fish fed diets with the highest level of guarana supplementation. As conclusion, guarana did not impair productivity and revealed a possible cytoprotective and hepatoprotective effect in fish infected by A. jandaei. Therefore, guarana seems to be an interesting additive to be included at levels of up to 1% in special feeds to be used prior to stressful situations in aquaculture. Additionally, guarana had no protective effect against lipid peroxidation and showed a pro-oxidant effect in diets with higher supplementation levels.

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Section: Introductionmentioning

confidence: 60%

Dietary guarana (Paullinia cupana) powder for tambaqui (Colossoma macropomum): growth, hemato-immunological parameters and bacterial challenge

Moreira

Fernandes

et al. 2022

Preprint

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“…Studies have described that excess of maternal nutrition during gestation, in combination with a high-fat postnatal diet, is capable of promoting phenotypic alterations, like increased body weight, hyperinsulinemia, hyperglycemia, hypertriglyceridemia and hypercholesterolemia [34,35]. In contrast, the introduction of foods such as green tea and guarana can improve serum levels of ALT, cholesterol, triglycerides, HDL and glucose in offspring [36,37]. In our study, the addition of açaí to the maternal high-fat diet reduced serum levels of total cholesterol in offspring P21 relative to the HF-P21 group.…”

Section: Discussionmentioning

confidence: 99%

Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring

et al. 2019

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Purpose Maternal high-fat diet affects offspring and can induce metabolic disorders such as non-alcoholic fatty liver disease (NAFLD). New therapeutic strategies are being investigated as way to prevent or attenuate this condition. The objective of this study was to evaluate the effect of açaí supplementation in the maternal high-fat diet on dams and offspring lipid metabolism. Methods Female Fisher rats were divided in four groups and fed a control diet (C), a high-fat diet (HF), an açaí supplemented diet (CA) and a high-fat diet supplemented with açaí (HFA) 2 weeks before mating, during gestation and lactation. The effects of açaí were evaluated in the male offspring after birth (P1) and weaning (P21). Results HFA reduced relative liver weight, fat and cholesterol liver content in dams and improved liver steatosis as confirmed by histological analyses. HFA increased serum cholesterol and expression of Srebpf1 and Fasn genes. In offspring, HFA decreased relative liver weight, and serum cholesterol only in P21. An increase in the Sirt1, Srebpf1 and Fasn genes expression was observed in P21. Conclusions These results suggest that açaí supplementation may attenuate NAFLD in dams and protect offspring from the detrimental effects of lipid excess from a maternal high-fat diet.

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“…A semente do guaraná apresenta diversos compostos bioativos em sua composição tais como metilxantinas, em maior concentrações a cafeína, além de proporções menores de outros alcaloides purínicos como a teobromina (3,7-dimetilxantina) e a teofilina (1,3-dimetilxantina); também contém taninos (catequinas, epicatequinas e proantocianidinas), saponinas e vestígios de outros compostos (Bittencourt et al, 2014;Lima, et al, 2017;Lima, et al, 2019;Lima, et al, 2018;Marques et al, 2016).…”

Section: Composição Fitoquímica Do Guaraná (Paullinia Cupana Kunth)unclassified

Guaraná (Paullinia cupana Kunth), marapuama (Ptychopetalum olacoides Benth.), genciana (Gentiana lutea L.), quassia (Quassia amara L.) e suas propriedades: uma breve revisão

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Ferreira²,

Bragança³

et al. 2022

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A descoberta e o manejo de recursos naturais são essenciais no processo de desenvolvimento social. Por milhares de anos, a humanidade tem se utilizado de plantas com os mais diversos intuitos, como, por exemplo, para o alívio e a cura de enfermidades. A diversidade florística brasileira também possibilitou que as comunidades nativas adquirissem e desenvolvessem conhecimentos associados ao uso de inúmeros vegetais. Esta breve revisão da literatura tem por objetivo fazer um levantamento das propriedades de quatro espécies vegetais – guaraná (Paullinia cupana Kunth), marapuama (Ptychopetalum olacoides Benth.), genciana (Gentiana lutea L.), quassia (Quassia amara L.) – amplamente utilizadas pelos nativos da região amazônica, especialmente devido as suas propriedades terapêuticas. Destaca-se, por fim, a existência de grande potencial para o aprofundamento de pesquisas nas espécies vegetais revisadas, principalmente no que se refere ao uso fitoterápico – uma vez que essas tem mostrado, de acordo com fontes consultadas, auxiliar nos mais diversos quadros de saúde.

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The effect of Guarana (Paullinia cupana) on metabolic and inflammatory parameters in adult male mice programmed by maternal obesity

Abstract: Guarana treatment at both stages of life reversed some of the alterations developed by the offspring of HF animals in adult life.

Cited by 11 publications

References 25 publications

Dietary guarana (Paullinia cupana) powder for tambaqui (Colossoma macropomum): growth, hemato-immunological parameters and bacterial challenge

Dietary guarana (Paullinia cupana) powder for tambaqui (Colossoma macropomum): growth, hemato-immunological parameters and bacterial challenge

Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring

Guaraná (Paullinia cupana Kunth), marapuama (Ptychopetalum olacoides Benth.), genciana (Gentiana lutea L.), quassia (Quassia amara L.) e suas propriedades: uma breve revisão

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