Objective: Poor ovarian reserve (POR) is one of the major problems that face the society. Different modalities have been tried to overcome this problem. The incidence of poor ovarian reserve is high, its incidence ranges from 9 to 24%. This incidence is unfortunately increasing as the women delay the age of marriage. And despite using different modalities, in cases of poor ovarian reserve both the pregnancy and live birth rates are low. GH is a peptide hormone produced from the anterior pituitary gland; it is produced due to the GHRH and is stopped in response to somatostatin hormone. GHRH and somatostatin are released from the hypothalamus. Growth hormone leads to the formation of IGF-1. IGF-1 and GH are vital in the formation of steroid hormones in the ovary. Methods :Between 2021 to 2022 at Ganna Fertility Center in Port-said, Egypt. A randomized control study. Study group will receive an ICSI cycle with GH supplementation and control group will only receive ICSI cycle. Demographic data, Hormonal levels of AMH levels and E2 levels, AFC, HMG doses, number of mature follicles and stimulation days, and the number of pregnancy occurrence are collected and statistically analyzed between 2 groups.Results: The mean age of the GH group (36.11 ± 3.21) is slightly higher than that of the other group (35.81 ± 3.7) . The mean duration of infertility is also the same between the GH (4.81 ± 2.16) and the control groups (4.73 ± 2). The mean AMH level is similar between the GH group (0.6 ± 0.22 ng/ml) and the control group (0.61 ± 0.22 ng/ml. The mean AFC is almost similar between the GH group (5.73 ± 1.88) and the control group (5.73 ± 1.88) and the control group (5.76 ± 1.72), with no significant difference between the two groups. The median AFC is 6 for the two groups, and they ranged from 3 to 9 in the GH and 3 to 8 in the control groups. The mean E2 level is statistically significantly higher in the GH side (1750.84 ± 732.23 pg/ml) than in the control group (1293.78 ± 574.96 pg/ml). There is non statistically significant difference in the mean number of mature follicles between the GH (4.46 ± 1.82) and the control groups (4.32 ± 1.68). The mean number of stimulation days for the GH side (9.84 ± 0.69) is statistically significantly lower than that of the other group (11.11 ± 0.74), with a p-value of less than 0.0001. The median number of stimulation days for the GH group is 10, with a range of 9-11, while the median for the control group is 11, ranging from 9-13. The mean HMG dose for the GH group (4427.03 ± 309.48) is significantly lower than that of the control group (4998.65 ± 331.76), with a p-value of less than 0.0001. The median HMG dose for the GH group is 4500, ranging from 4050-4950, while the median for the control group is 4950, ranging from 4050-5850. Out of the 37 patients in the GH group, 11 (29.73%) achieved pregnancy, while in the control group, 7 (18.92%) achieved pregnancy. However, the p-value for the difference in pregnancy occurrence between the two groups is 0.2848, which is not statistically signifi...