The effect of growth hormone and prolactin preparations on the intermediary metabolism of rat adipose tissue

Hamid, Muhammad Akhter; Rubinstein, David; Ferguson, K. A.; Beck, J. C.

doi:10.1016/0304-4165(65)90440-x

Cited by 24 publications

(7 citation statements)

References 28 publications

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“…Although the present results do not allow a conclusion to be drawn on this question, one may speculate a role of the amino acids in stimulating Prl secretion, which in turn, along with GH and Ins, may act in the conversion of the amino acids into tissue proteins. This suggestion seems more tenable when viewed in connection with previous reports that Prl administration results in increased nitrogen retention and general metabolic effects similar to those reported for GH (9)(10)(11)(12). In addition, McAtee and Trenkle (8) have recently observed that plasma levels of Prl are decreased during fasting and are increased after feeding and by arginine infusion.…”

Section: Discussionmentioning

confidence: 52%

Plasma Levels of Prolactin, Growth Hormone, and Insulin in Sheep Following the Infusion of Arginine, Leucine and Phenylalanine

Davis

1972

Endocrinology

108

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The effects of amino acid infusions on plasma levels of prolactin (Prl), growth hormone (GH) and insulin (Ins) in sheep were studied using specific double antibody radioimmunoassay systems.The infusion of arginine (0.5 g/kg), leucine (0.2 g/kg) and phenylalanine (0.3 g/kg) into the carotid artery (via an indwelling cannula) of mature, anestrus ewes, resulted in a significant increase in plasma levels of Prl. Arginine and leucine also stimulated significant increases in plasma GH and insulin levels, while the phenylalanine treatment significantly increased plasma levels of insulin but not GH. The intrajugular injection of arginine (0.5 g/kg) into immature male and female sheep also produced significant increases in Prl, GH and insulin.It was also observed that physically or psychologically stressful factors may produce a significant elevation in plasma levels of Prl, but do not appear to affect GH secretion in sheep. (Endocrinology 9 1 : 205, 1972)

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Section: Discussionmentioning

confidence: 52%

Plasma Levels of Prolactin, Growth Hormone, and Insulin in Sheep Following the Infusion of Arginine, Leucine and Phenylalanine

Davis

1972

Endocrinology

108

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“…Results of several stud ies seem contradictory, indicating stimula tory as well as inhibitory effects of prolactin upon lipid mobilization from adipose tissue [33][34][35][36], Perhaps the effects of prolactin on fat mobilization are also time of day-depen dent. We are presently investigating this pos sibility.…”

Section: Discussionmentioning

confidence: 97%

Bromocriptine Alters Hormone Rhythms and Lipid Metabolism in Swine

Cincotta¹,

Meier²,

Southern

1989

Ann Nutr Metab

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Hormones, metabolites and activities involved in lipid synthesis were assayed in pigs made leaner by bromocriptine treatment. Market size female swine were allowed free access to food under natural lighting conditions and implanted with bromocriptine pellets designed to release 10 mg/pig/day for 28 days in an effort to inhibit prolactin secretion. Between the 2nd and 3rd week of treatment, plasma samples were obtained from each group at 4-hour intervals throughout the day for assays of prolactin, cortisol, insulin, triglyceride, cholesterol and glucose concentrations. Twenty-eight or thirty days after the implantations, all animals were sacrificed for determinations of backfat thickness and insulin binding in the liver. At sacrifice, bromocriptine treatment reduced backfat thickness by 14% and insulin binding to partially purified hepatic membranes by 39% compared with control values. At 14 days following implantations, there were dramatic daily variations in plasma cortisol and prolactin levels in the control pigs and these rhythms were markedly altered in phase and amplitude in the bromocriptine-treated pigs. Bromocriptine reduced by 45, 20 and 13% the high levels of triglyceride, glucose, and cholesterol, respectively, that were found in control pigs near sunset. Plasma insulin concentrations did not vary during the day in control pigs and bromocriptine did not influence the insulin levels. The findings support important roles for a temporal synergism of cortisol and prolactin rhythms in maintaining hepatic lipogenic responsiveness to insulin. Bromocriptine treatment alters these hormonal relations and reduces lipid synthesis.

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“…Thus, prolactin administration can lead to increased weight gain in female rats [2], to in creased protein synthesis in rat adipose tissue [20], to bone growth in hypophysectomized rats [39], and to the growth of lean body mass in sheep [36]. Serum prolactin concentration is positively correlated with the rate of weight gain in wo men with anorexia nervosa [3,22], in lambs [14], and in bull calves [8,24,33,36].…”

Section: Discussionmentioning

confidence: 99%

Hamster Prolactin: Physiological Changes in Blood and Pituitary Concentrations as Measured by a Homologous Radioimmunoassay

Borer¹,

Kelch²,

Corley³

1982

Neuroendocrinology

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A specific and sensitive homologous radioimmunoassay (RIA) for determination of hamster prolactin is described and compared to heterologous hamster prolactin RIA and to the homologous and heterologous RIAs for rat prolactin. With this method, we have determined that, in the golden hamster, diurnal plasma prolactin fluctuations have a mean interpeak interval of 1.5 h, that serum prolactin concentrations are influenced by day length, by ether vapors, by animal’s gender, and by refeeding following a fast but not by neurosurgical procedures which increase somatic growth and serum GH concentration in adult hamsters. Variations in day length influenced pituitary prolactin content and concentration, and pituitary removal abolished prolactin secretory responses to ether stress. A heterologous RIA for hamster prolactin which utilizes radioiodinated rat prolactin and rabbit antihamster prolactin serum (RK1–15) represents the most advantageous method for the measurement of hamster prolactin because of its high sensitivity (0.14 ng/ml), high antiserum binding to iodinated rat prolactin, and the ability to measure both hamster and rat prolactin.

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The effect of growth hormone and prolactin preparations on the intermediary metabolism of rat adipose tissue

Cited by 24 publications

References 28 publications

Plasma Levels of Prolactin, Growth Hormone, and Insulin in Sheep Following the Infusion of Arginine, Leucine and Phenylalanine

Plasma Levels of Prolactin, Growth Hormone, and Insulin in Sheep Following the Infusion of Arginine, Leucine and Phenylalanine

Bromocriptine Alters Hormone Rhythms and Lipid Metabolism in Swine

Hamster Prolactin: Physiological Changes in Blood and Pituitary Concentrations as Measured by a Homologous Radioimmunoassay

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