The effect of growth architecture on the induction and decay of bleomycin and X-ray-induced bystander response and genomic instability in lung adenocarcinoma cells and blood lymphocytes

Chinnadurai, Mani; Paul, Solomon F.D.; Prakash, Venkatachalam

doi:10.3109/09553002.2012.726397

Cited by 15 publications

(5 citation statements)

References 33 publications

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“…Most of the brain in the track of the microbeam is composed of normal tissue and in the healthy rats this produced signals. While strain and cell line differences in bystander signalling support the existence of a neutral or blocking effect associated with genomic instability [88], cancer phenotype [89], cancer susceptibility [90], mutant p53 [67,91,92] and radioresistance [93e95], this appears to be the first report that bystander effects in the healthy cage mate and abscopal effects in unirradiated tissues of the directly exposed rats can both be blocked by the presence of a glioma in the brain of the rat receiving direct irradiation. Our conclusion is that the presence of tumour in the brain actively counteracts signal production.…”

Section: Discussionmentioning

confidence: 99%

Use of synchrotron medical microbeam irradiation to investigate radiation-induced bystander and abscopal effects in vivo

et al. 2015

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The question of whether bystander and abscopal effects are the same is unclear. Our experimental system enables us to address this question by allowing irradiated organisms to partner with unexposed individuals. Organs from both animals and appropriate sham and scatter dose controls are tested for expression of several endpoints such as calcium flux, role of 5HT, reporter assay cell death and proteomic profile. The results show that membrane related functions of calcium and 5HT are critical for true bystander effect expression. Our original inter-animal experiments used fish species whole body irradiated with low doses of X-rays, which prevented us from addressing the abscopal effect question. Data which are much more relevant in radiotherapy are now available for rats which received high dose local irradiation to the implanted right brain glioma. The data were generated using quasi-parallel microbeams at the biomedical beamline at the European Synchrotron Radiation Facility in Grenoble France. This means we can directly compare abscopal and "true" bystander effects in a rodent tumour model. Analysis of right brain hemisphere, left brain and urinary bladder in the directly irradiated animals and their unirradiated partners strongly suggests that bystander effects (in partner animals) are not the same as abscopal effects (in the irradiated animal). Furthermore, the presence of a tumour in the right brain alters the magnitude of both abscopal and bystander effects in the tissues from the directly irradiated animal and in the unirradiated partners which did not contain tumours, meaning the type of signal was different.

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Section: Discussionmentioning

confidence: 99%

Use of synchrotron medical microbeam irradiation to investigate radiation-induced bystander and abscopal effects in vivo

et al. 2015

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“…Breast cancer (BC) is most frequently diagnosed cancer and remains one of leading cause of cancer-related death in women worldwide [1] , [2] . Altered signaling pathways [3] , [4] , [5] , [6] , [7] , mutation in genes [8] , activation of oncogenic pathways [9] , [10] , [11] , DNA damage [12] , [13] and non-targeted effects of chemotherapeutic agents [14] , [15] , [16] , [17] significantly contributes in cancer progression. Therapeutic strategies including chemotherapy [18] , application of toxins obtained from pathogen [19] , [20] , [21] , [22] , [23] , [24] have shown limited clinical efficacy against cancer.…”

Section: Introductionmentioning

confidence: 99%

Role of let-7 family microRNA in breast cancer

Thammaiah

Jayaram

2016

Non-coding RNA Research

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Metastasis and resistance to therapy significantly contribute to cancer-related deaths. Growing body of evidence suggest that altered expression of microRNAs (miRNAs) is one of the root cause of adverse clinical outcome. miRNAs such as let-7 are the new fine tuners of signaling cascade and cellular processes which regulates the genes in post-transcriptional manner. In this review, we described the regulation of let-7 expression and the involvement of molecular factors in this process. We discussed the mechanism by which let-7 alter the expression of genes involved in the process of tumorigenesis. Further, we listed the pathways targeted by let-7 to reduce the burden of the tumor. In addition, we described the role of let-7 in breast cancer metastasis and stemness properties. This article will provide the in-depth insight into the biology of let-7 miRNA and its role in the breast cancer progression.

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“…Bystander cells are the normal cells that are surrounding the tumor or infected cells. Bystander effects have been studied extensively to both radiation and chemotherapeutic treatment [30][31][32][33]. In present scenario, human intestine infection with Enterococcus faecalis activates macrophages that secretes increased TNF-α, that acts upon the bystander epithelial cells and induces a pro-proliferation and anti-apoptotic pathways [34].…”

Section: Tumor Growthmentioning

confidence: 99%

Cancer Progression Related with Tumor-associated Macrophages

Ethiraj¹,

Loganathan²,

Arul³

2016

cor

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Tumor-associated macrophages are one of the main populations of inflammatory cells in cancers that favor tumor cell growth and survival. Tumor-derived factors such as VEGF-A and CSF-1 recruit the macrophages in tumor micro environment and alter their phenotype in M1 to M2 or tumor-associated macrophages by secretion of several cytokines including IL-4, IL-13 and VEGF-A. In return tumor-associated macrophages released growth factors and cytokine that helps in cancer cell proliferation and metastasis. Tumor-associated macrophage secreted cytokines promotes the angiogenesis and lymphangiogenesis that assist tumor cell to metastasize in distant organs. Importantly, tumor-associated macrophages promote an immunosuppressive environment with the help of other immune cells in the tumor-bearing host that helps tumor to grow unchecked and unchallenged. In addition, tumor-associated macrophages induce resistance against cancer therapy and boost tumor regrowth after therapy. In this review, we discuss the role of tumor-associated macrophages in the pathobiology of cancer. Understanding of the crucial role of tumor-associated macrophages in cancer progression may help to assess potential therapeutic strategies.

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The effect of growth architecture on the induction and decay of bleomycin and X-ray-induced bystander response and genomic instability in lung adenocarcinoma cells and blood lymphocytes

Abstract: BLM-induced genomic instability in the progeny of bystander cells and their significance in therapy-induced second malignancy may not be eliminated completely.

Cited by 15 publications

References 33 publications

Use of synchrotron medical microbeam irradiation to investigate radiation-induced bystander and abscopal effects in vivo

Use of synchrotron medical microbeam irradiation to investigate radiation-induced bystander and abscopal effects in vivo

Role of let-7 family microRNA in breast cancer

Cancer Progression Related with Tumor-associated Macrophages

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