The effect of Green green tea consumption on body mass index, lipoprotein, liver enzymes, and liver cancer: An updated systemic review incorporating a meta-analysis

Li, Mingzhen; Duan, Yunjie; Wang, Ying; Chen, Lei; Abdelrahim, Mohamed; Yan, Jun

doi:10.1080/10408398.2022.2113360

Cited by 7 publications

(4 citation statements)

References 42 publications

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“…Our MR nding of a positive correlation between tea intake and the risk of liver and intrahepatic biliary cancer was novel. A recent meta-analysis showed that the risk of getting liver cancer was signi cantly reduced by drinking green tea compared to not drinking green tea, and this impact was seen in all populations studied (27). An inverse relationship between tea drinking and the incidence of primary liver cancer was also discovered in a population-based prospective cohort study of Chinese women (28).…”

Section: Discussionmentioning

confidence: 90%

Tea consumption and risk of digestive tract tumors: a two-sample Mendelian randomization study

Wang

Xing

Jin

et al. 2023

Preprint

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Background-Tea intake is thought to have anti-cancer effects, but it is unclear whether tea intake has a causal association with digestive tract cancers. Our goal in conducting this two-sample Mendelian randomization (MR) study was to learn more about the possible causal link between tea consumption and digestive system tumors. Materials and Methods-At the genome-wide significance level (P < 5×10 − 8), thirty-two independent single nucleotide polymorphisms (SNPs) related to tea consumption were adopted as instrumental variables. The UK Biobank Consortium provided the summary statistics for digestive tract cancer. We employed inverse variance weighted (IVW) as our primary method, and we conducted a set of sensitivity analyses—including MR Pleiotropy RESidual Sum and Outlier, MR-Egger, and weighted median—to identify heterogeneity and pleiotropy. Results-The IVW analysis method showed that genetic liability to tea intake was associated with increased risk of liver and intrahepatic biliary cancer[OR = 1.0019, 95% confidence interval (CI) = 1.0003–1.0035, P = 0.020]. There was no statistically significant link between tea drinking and the development of other digestive tract cancers. [Esophagus cancer: OR = 1.0000, 95% CI = 0.9975–1.0025, P = 0.978; Stomach cancer: OR = 1.0007, 95% CI = 0.9982–1.0032, P = 0. 584; Pancreas cancer: OR = 0.9994, 95% CI = 0.9972–1.0016, P = 0.604; Small intestine cancer: OR = 0.9992, 95% CI = 0.9979–1.0006, P = 0. 281; colon cancer: OR = 0.9989, 95% CI = 0.99333–1.00446, P = 0. 707; Rectal cancer: OR = 1.0005, 95% CI = 0.9969–1.0042, P = 0. 767] was noted. Conclusion-This Mendelian randomization study indicates that tea intake might be a factor in an increased risk of liver and intrahepatic biliary cancer, whereas there was no evidence of a genetically predicted causal link between drinking tea and developing other malignancies of the digestive tract.

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Section: Discussionmentioning

confidence: 90%

Tea consumption and risk of digestive tract tumors: a two-sample Mendelian randomization study

Wang

Xing

Jin

et al. 2023

Preprint

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“…According to guidelines, a modified diet score for Chinese cardiovascular health was defined as the numbers of healthy components (consumption of ≥500 g/d of fruits and vegetables; ≥200 g/week of fish; ≥125 g/d of soybean products; <75 g/d of red meat; and ≥50 g/mo of tea) . It was used in this study based on the evidence that the 5 components in the score were all related to blood lipids . Ideal physical activity was defined as having at least 150 minutes per week of moderate physical activity, at least 75 minutes per week of vigorous physical activity, or at least 150 minutes per week of both.…”

Section: Methodsmentioning

confidence: 99%

“… 26 , 27 , 28 It was used in this study based on the evidence that the 5 components in the score were all related to blood lipids. 5 , 29 , 30 Ideal physical activity was defined as having at least 150 minutes per week of moderate physical activity, at least 75 minutes per week of vigorous physical activity, or at least 150 minutes per week of both. Height and weight were measured, and body mass index (BMI) was calculated as weight in kilograms divided by height in meters squared.…”

Section: Methodsmentioning

confidence: 99%

Age and Genetic Risk Score and Rates of Blood Lipid Changes in China

Liu

et al. 2023

JAMA Netw Open

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ImportanceBlood lipids are the primary cause of atherosclerosis. However, little is known about relationships between rates of blood lipid changes and age and genetic risk.ObjectiveTo evaluate associations of blood lipid change rates with age and polygenic risk.Design, Setting, and ParticipantsThis cohort is from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China, which was established from 1998 to 2008. Participants were followed up until 2020 (mean [SD] follow-up, 13.8 [4.3] years) and received 4 repeated lipid measurements. Data analysis was performed from June to August 2022. A total of 47 691 participants with available genotype data were recruited, and 37 317 participants aged 18 years or older were included in the final analysis after excluding participants who were lost to follow-up or with major chronic diseases, and those without blood lipid measurements at baseline and any follow-up survey.ExposuresAge and polygenic risk scores based on 126 lipid-related genetic variants.Main Outcomes and MeasuresThe estimated annual changes (EAC) of blood lipids in milligrams per deciliter.ResultsThis study evaluated 37 317 participants (mean [SD] age of 51.37 [10.82] years; 15 664 [41.98%] were male). The associations of EACs of blood lipids with age differed substantially between male and female participants. Male participants experienced declining change as they got older for total cholesterol (EAC, 0.34 [95% CI, 0.14 to 0.54] mg/dL for age &lt;40 years vs 0.01 [95% CI, −0.11 to 0.13] mg/dL for age ≥60 years), triglyceride (EAC, 3.28 [95% CI, 2.50 to 4.07] mg/dL for age &lt;40 years vs −1.70 [95% CI, −2.02 to −1.38] mg/dL for age ≥60 years), and low-density lipoprotein cholesterol (LDL-C) (EAC, 0.15 [95% CI, −0.02 to 0.32] mg/dL for age &lt;40 years vs 0.01 [95% CI, −0.10 to 0.11] mg/dL for age ≥60 years). Female participants had inverse V-shaped associations and the greatest rate of change appeared in the age group of 40 to 49 years (EAC for total cholesterol, 1.33 [95% CI, 1.22 to 1.44] mg/dL; EAC for triglyceride, 2.28 [95% CI, 1.94 to 2.62] mg/dL; and EAC for LDL-C, 0.94 [95% CI, 0.84 to 1.03] mg/dL). Change in levels of blood lipids were also associated with polygenic risk. Participants at low polygenic risk tended to shift toward lower blood lipid levels, with EACs of −0.16 (95% CI, −0.25 to −0.07) mg/dL; −1.58 (95% CI, −1.78 to −1.37) mg/dL; and −0.13 (95% CI, −0.21 to −0.06) mg/dL for total cholesterol, triglyceride, and LDL-C, respectively. Participants with high polygenic risk had the greatest rates of change for total cholesterol, triglyceride, and LDL-C (EAC, 1.12 [95% CI, 1.03 to 1.21] mg/dL; EAC, 3.57 [95% CI, 3.24 to 3.91] mg/dL; and EAC, 0.73 [95% CI, 0.65 to 0.81] mg/dL, respectively). Similar patterns were also observed across sex and age groups.Conclusions and RelevanceIn this cohort study, EACs of blood lipids were significantly associated with age and polygenic risk, suggesting that prevention strategies for lipids should focus on individuals with high genetic risk and in the critical age window.

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“…In recent decades, many observational studies and randomized controlled trials (RCTs) focusing on the association between supplement intake and liver enzymes levels have been published (25,26). Thus, before developing consensus and guideline policies, a comprehensive assessment of the quality of available evidence on the association between natural products and dietary supplements and liver injury outcomes is required.…”

Section: Introductionmentioning

confidence: 99%

Natural products and dietary interventions on liver enzymes: an umbrella review and evidence map

Li,

Wu,

Zhao

et al. 2024

Front. Nutr.

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BackgroundThe association between natural products and dietary interventions on liver enzymes is unclear; therefore, this study aimed to examine their effects on liver enzymes in adults.MethodsPubMed, Embase, and Cochrane Library of Systematic Reviews databases were searched from inception until March 2023. The Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) systems were used to assess the methodological and evidence quality, and the therapeutic effects were summarized in a narrative form.ResultsA total of 40 meta-analyses on natural products (n = 25), dietary supplements (n = 10), and dietary patterns (n = 5) were evaluated, and results were presented in a narrative form. The overall methodological quality of the included studies was relatively poor. The results indicated that positive effects were observed for nigella sativa, garlic, artichoke, curcumin, silymarin, vitamin E, vitamin D, L-carnitine, propolis, and polyunsaturated fatty acids on certain liver enzymes. The dietary patterns, including high-protein, Mediterranean, and calorie-restriction diets and evening snacks, may reduce liver enzymes; however, other supplements and herbs did not reduce liver enzyme levels or have minimal effects. The evidence quality was generally weak given the risk of bias, heterogeneity, and imprecision.ConclusionThis umbrella review suggests that natural products and dietary interventions have beneficial therapeutic effects on liver enzymes levels. Further clinical trials are necessary to establish the effectiveness of supplements that reduce liver enzymes.

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The effect of Green green tea consumption on body mass index, lipoprotein, liver enzymes, and liver cancer: An updated systemic review incorporating a meta-analysis

Cited by 7 publications

References 42 publications

Tea consumption and risk of digestive tract tumors: a two-sample Mendelian randomization study

Tea consumption and risk of digestive tract tumors: a two-sample Mendelian randomization study

Age and Genetic Risk Score and Rates of Blood Lipid Changes in China

Natural products and dietary interventions on liver enzymes: an umbrella review and evidence map

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