The effect of grape-seed extract on 24 h energy intake in humans

Vogels, N.; Nijs, Ilse M.T.; Westerterp-Plantenga, Margriet S.

doi:10.1038/sj.ejcn.1601863

Cited by 38 publications

(22 citation statements)

References 32 publications

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“…Wren et al (2002) found feeding GSE to rats at levels of up to 2.0% for a period of 90 days resulted in all groups of animals gaining weight during the trial and that food consumption in the 2.0% group was significantly higher than that of the control group. However, Moreno et al (2003) and Vogel et al (2004) reported decreased BWs in mice and rats while other researchers (Yamakoshi et al, 2002;Gontheir et al, 2003) found GSE treatments did not produce any significant changes in BW in rats.…”

Section: Resultsmentioning

confidence: 79%

Feeding grape seed extract to horses: effects on health, intake and digestion

Davies

Krebs

Barnes

et al. 2009

Animal

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A feeding trial involving four Thoroughbred race horses was undertaken to establish whether inclusion of grape seed extract (GSE) in the diet of horses undergoing mild exercise had any effects on their general health, intake and digestion. Supplementation with GSE had no effect on either feed or water intake of the horses and the supplement was readily palatable to the horses at all levels of inclusion. Feeding GSE caused no adverse effects in terms of animal health (temperature, pulse and respirations rates), and there were some positive effects related to a presumed alteration in fermentation in the hindgut. Feeding GSE increased faecal pH, changing from acid faeces (pH 6.6) when no GSE was fed to neutral faeces (pH 7.0) when 150 mg GSE/kg body weight (BW) was fed. In addition, blood glucose concentrations were significantly ( P , 0.05) decreased when GSE was fed at 100 and 150 mg/kg BW (5.50 6 0.26 and 5.32 6 0.72 mmol/l, respectively) compared with the control diet (5.77 6 0.31 mmol/l). The actual mechanisms causing these alterations are yet to be elucidated, but could have important implications for the prevention of acidosis.

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Section: Resultsmentioning

confidence: 79%

Feeding grape seed extract to horses: effects on health, intake and digestion

Davies

Krebs

Barnes

et al. 2009

Animal

View full text Add to dashboard Cite

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“…Although the data presented in Table 2 do not describe a wine-associated decrease in triglyceride levels, there is some evidence that GSE or red wine consumption (150 mL for 3 weeks) may combat obesity by decreasing appetite, especially in females (Vogels et al 2004, Djurovic et al 2007). One study found that a diet with 10% of energy derived from white wine or grape juice for 3 months reduced percent body fat, waist circumference, blood pressure, blood glucose, insulin, triglycerides, and cholesterol, and body weight in obese subjects (Flechtner-Mors et al 2004).…”

Section: Lipid Effectsmentioning

confidence: 99%

Wine and Health: A Review

Guilford

Pezzuto

2011

Am. J. Enol. Vitic.

159

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Abstract:As indicated by epidemiological studies, regular and moderate wine consumption, particularly red wine, has been associated with health benefits. Clinical studies and work performed with animal models indicate that wine may protect against cardiovascular disease, atherosclerosis, hypertension, certain types of cancer, type 2 diabetes, neurological disorders, and metabolic syndrome. The mechanism of action has been attributed to antioxidant, lipid regulating, and anti-inflammatory effects. A variety of wine constituents have been studied in various disease models. Both the alcoholic and polyphenolic components of wine are believed to contribute to these beneficial effects. As wine is a complex mixture, it is likely that a multitude of chemical constituents, as well as their metabolites, work synergistically to impact human health. In sum, although wine drinking may be contraindicated in certain individuals, in healthy people, regular consumption of moderate amounts of wine may protect against certain chronic health conditions.

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“…Diet is closely related to the development of obesity; however, certain food components have been reported to exhibit antiobese activity. [48][49][50] In this study, we explored the effects of RMR on fat accumulation in cellular as well as animal experiments. Our data suggest that the inhibitory effects of RMR on weight gain and the hypertrophy of fat cells were primarily because of lipolytic activity and to a mild antiappetite potency.…”

mentioning

confidence: 99%

Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet

Chen

Lee

et al. 2008

Int J Obes

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Objective: To investigate the influences of red mold rice (RMR) on obesity and related metabolic abnormalities. Methods and results:The 3T3-L1 cell line was used to examine the effects of RMR extracts on preadipocytes and on mature adipocytes. Both water and ethanol extracts of RMR had inhibitory effects on 3T3-L1 preadipocyte proliferation and differentiation. Water extracts of RMR enhanced the lipolysis activity in mature adipocytes, which negatively correlated with the triglyceride content within cells. RMR treatment did not affect heparin-releasable lipoprotein lipase activity in mature adipocytes. Furthermore, animal studies were carried out to explore the antiobesity effects of RMR. The control group of male Wistar rats were fed regular laboratory feed, whereas the other groups were fed the high-fat (HF) diet supplemented with lovastatin, rice or RMR (0.4 and 2%, w w À1 ). The relative caloric intakes of the control and HF groups were 3.34 and 4.85 kcal g À1 , respectively. After 6 weeks, rats treated with RMR at the 0.4 and 2% doses had lower weight gain and less fat pads mass accompanied with smaller fat cells than did the HF-diet rats. These effects probably resulted from an increase in the lipolysis activity of adipose tissue and a reduction in food/energy consumption. On the other hand, the RMR supplement significantly reduced serum total cholesterol, serum low-density lipoprotein (LDL) cholesterol, the ratio of LDL to high-density lipoprotein (HDL) cholesterol and serum insulin in the HF group. Moreover, the 2% RMR treatment significantly increased serum HDL cholesterol. Conclusion: This study reveals for the first time that RMR can prevent body fat accumulation and improve dyslipidemia. The antiobesity effects of RMR mainly derive from the lipolytic activity and mild antiappetite potency of RMR. In addition, extracts of RMR suppressed the proliferation and differentiation in 3T3-L1 preadipocytes, which might have contributed to the inhibition of new adipocyte formation or hyperplasia in adipose tissue.

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The effect of grape-seed extract on 24 h energy intake in humans

Cited by 38 publications

References 32 publications

Feeding grape seed extract to horses: effects on health, intake and digestion

Feeding grape seed extract to horses: effects on health, intake and digestion

Wine and Health: A Review

Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet

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