The effect of grand maternal nicotine exposure during gestation and lactation on lung integrity of the F2 generation

Maritz, Gert S.; Mutemwa, Muyunda

doi:10.1002/ppul.22783

Cited by 15 publications

(14 citation statements)

References 39 publications

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“…We found that the changes in MRSA induced by cigarette smoke exposure persisted even after the stress was removed, suggesting that cigarette smoke exposure induces heritable changes in MRSA. It has been shown that cigarette smoke and secondhand smoke exposures cause heritable changes in mice and rats (45)(46)(47)(48). The data in humans are less vigorous, but one study demonstrated higher rates of asthma in children and grandchildren of women who smoked during pregnancy (49).…”

Section: Discussionmentioning

confidence: 97%

Analysis of the Effects of Cigarette Smoke on Staphylococcal Virulence Phenotypes

et al. 2015

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f Cigarette smoking is the leading preventable cause of death, disease, and disability worldwide. It is well established that cigarette smoke provokes inflammatory activation and impairs antimicrobial functions of human immune cells. Here we explore whether cigarette smoke likewise affects the virulence properties of an important human pathogen, Staphylococcus aureus, and in particular methicillin-resistant S. aureus (MRSA), one of the leading causes of invasive bacterial infections. MRSA colonizes the nasopharynx and is thus exposed to inhalants, including cigarette smoke. MRSA exposed to cigarette smoke extract (CSE-MRSA) was more resistant to macrophage killing (4-fold higher survival; P < 0.0001). CSE-MRSA demonstrated reduced susceptibility to cell lysis (1.78-fold; P ‫؍‬ 0.032) and antimicrobial peptide (AMP) (LL-37) killing (MIC, 8 M versus 4 M). CSE modified the surface charge of MRSA in a dose-dependent fashion, impairing the binding of particles with charge similar to that of AMPs by 90% (P < 0.0001). These changes persisted for 24 h postexposure, suggesting heritable modifications. CSE exposure increased hydrophobicity by 55% (P < 0.0001), which complemented findings of increased MRSA adherence and invasion of epithelial cells. CSE induced upregulation of mprF, consistent with increased MRSA AMP resistance. S. aureus without mprF had no change in surface charge upon exposure to CSE. In vivo, CSE-MRSA pneumonia induced higher mouse mortality (40% versus 10%) and increased bacterial burden at 8 and 20 h postinfection compared to control MRSA-infected mice (P < 0.01). We conclude that cigarette smoke-induced immune resistance phenotypes in MRSA may be an additional factor contributing to susceptibility to infectious disease in cigarette smokers.

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Section: Discussionmentioning

confidence: 97%

Analysis of the Effects of Cigarette Smoke on Staphylococcal Virulence Phenotypes

et al. 2015

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“…Animal studies support multi-generation effects of nicotine exposure during gestation and lactation on the lungs, 11 but evidence in humans is scarce and controversial. There are reports that the risk of asthma increases for a child if the maternal grandmother had smoked when pregnant with the child’s mother, even if the child was not exposed to the mother’s smoking in utero 2 , 12 , 13 .…”

Section: Introductionmentioning

confidence: 99%

A three-generation study on the association of tobacco smoking with asthma

Accordini

Calciano

Johannessen

et al. 2018

International Journal of Epidemiology

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BackgroundMothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.MethodsBetween 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.ResultsFathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55).ConclusionsFathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.FundingEuropean Union (Horizon 2020, GA-633212).

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“…5 Evidence to support this is accumulating in animals and humans regarding cigarette smoking. For example, animal experiments have shown that (1) offspring of mice exposed to cigarette smoke during pregnancy had lower expression of Wnt genes 6 and of other genes involved in lung development 7 ; (2) rats developed emphysematous lesions in their lungs in association with their grandmothers’ exposure to nicotine when pregnant, regardless of whether this was via maternal or paternal prenatal exposure 8 ; and (3) prenatal exposure of rats to nicotine resulted in reduced expression of peroxisome proliferator-activated receptor-γ in the respiratory system of the offspring and in changes in respiratory responses to methacholine challenge; there were sex-specific effects, with male offspring exhibiting increased effects. The next generation also had the same response to methacholine challenges even though they had not been exposed to nicotine in utero themselves.…”

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confidence: 99%

“…The transgenerational findings in rats 8,9 raise the question as to whether there are similar intergenerational effects on human respiratory responses. One much-quoted study published in 2005 indicated that childhood asthma was influenced not only by prenatal smoking by the mother but also by the exposure of the mother in utero to her own mother’s smoking.…”

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confidence: 99%

Do Grandmaternal Smoking Patterns Influence the Etiology of Childhood Asthma?

Miller

Henderson

Northstone

et al. 2014

Chest

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Background:Animal data suggest that tobacco smoke exposure of a mother when she is in utero influences DNA methylation patterns in her offspring and that there is an effect on the respiratory system, particularly airway responsiveness. The only study, to our knowledge, in humans suggests that there is a similar effect on asthma. The present study tests whether an association with respiratory problems can be confirmed in a large population study and aims to determine whether in utero exposure of the father has similar effects on his offspring.Methods:Information from the Avon Longitudinal Study of Parents and Children was used to compare the offspring of women and of men who had themselves been exposed to cigarette smoke in utero; separate analyses were performed for children of women smokers and nonsmokers. The outcome measures were trajectories of history of early wheezing, doctor-diagnosed asthma by age 7 years, and results of lung function and methacholine challenge tests at 8 years. A variety of social and environmental factors were taken into account; offspring sexes were examined separately.Results:There was no association with any outcome in relation to maternal prenatal exposure. There was some evidence of an increase in asthma risk with paternal prenatal exposure when the study mother was a nonsmoker (adjusted OR, 1.17; 95% CI, 0.97-1.41). This was particularly strong for girls (adjusted OR, 1.39; 95% CI, 1.04-1.86).Conclusions:We did not find that maternal prenatal exposure to her mother’s smoking had any effect on her children’s respiratory outcomes. There was suggestive evidence of paternal prenatal exposure being associated with asthma and persistent wheezing in the granddaughters.

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The effect of grand maternal nicotine exposure during gestation and lactation on lung integrity of the F2 generation

Abstract: Grand-maternal nicotine exposure induces structural changes in the lungs of the F2 generation that resembled premature aging.

Cited by 15 publications

References 39 publications

Analysis of the Effects of Cigarette Smoke on Staphylococcal Virulence Phenotypes

Analysis of the Effects of Cigarette Smoke on Staphylococcal Virulence Phenotypes

A three-generation study on the association of tobacco smoking with asthma

Do Grandmaternal Smoking Patterns Influence the Etiology of Childhood Asthma?

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