The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations

Abstract

Objectives:We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations.Methods:We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic polypeptide receptor (GIPR) among 2884 community-based individuals from Han Chinese populations. Linear analysis was applied to test the associations of these variants with visceral fat area (VFA) and subcutaneous fat area (SFA) quantified by magnetic resonance imaging as well as glucose-related traits.Results:We found that the C allele of rs4794008 of GIP tended to increase the VFA and the VFA/SFA ratio in all subjects (P=0.050 and P=0.054, respectively), and rs4794008 was associated with the VFA/SFA ratio in males (P=0.041) after adjusting for the BMI. The VFA-increasing allele of rs4794008 was not related to any glucose metabolism traits. However, rs9904288 of GIP was associated with the SFA in males as well as glucose-related traits in all subjects (P range, 0.004–0.049), and the GIPR variants displayed associations with both fat- and glucose-related traits.Conclusions:The results could provide the evidence that GIP might modulate visceral fat accumulation via incretin function or independent of incretin.

Old Paradoxes and New Opportunities for Appetite Control in Obesity

“…Genetic perturbations in GIP signaling favor the development of obesity: polymorphisms near the GIPR locus are associated to an increased risk of obesity and perturbations in glucose metabolism [57,58], while variants in the GIP gene have been linked with increased adiposity [59,60].…”

The Link between Three Single Nucleotide Variants of the GIPR Gene and Metabolic Health

“…In the study of Zhang et al where the genetic-pleiotropy-informed conditional false discovery rate approach was used, rs2334255 was identified as a novel common variant associated with both, obesity and T2D risk [ 21 ]. Another study investigating the relationship of this variant with adiposity traits was an analysis of Wang et al Only samples from the Han Chinese population had been included, and the results showed that rs2334255 was neither associated with the visceral fat area nor with subcutaneous area [ 36 ]. The association of this SNV with other anthropometric measurements and metabolic parameters is not available.…”

Glucose-Dependent Insulinotropic Polypeptide—A Postprandial Hormone with Unharnessed Metabolic Potential

“…By contrast, a recent study showed a reduced GIP potency on the GIPR variants R190Q (rs139215588) and E288G (rs143430880), which were both linked to reduced BMI and reduced bone mineral density (86). Single-nucleotide polymorphisms in GIP and GIPR have also been linked to increased visceral fat in Chinese populations (159).…”