The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rats

Afshari, Ali; Shirpoor, Alireza; Farshid, Amir Abbas; Saadatian, R; Rasmi, Yousef; Saboory, Ehsan; Ilkhanizadeh, Behrouz; Allameh, Abdolamir

doi:10.1016/j.foodchem.2006.01.013

Cited by 141 publications

(98 citation statements)

References 36 publications

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“…It is measured by determining the concentration of MDA in the blood (Ohkawa et al, 1979). The decrease in MDA levels of extract-treated rats (Table 5) may have increased the activity of glutathione peroxidase in the rats and hence caused inactivation of lipid peroxidation as suggested by Afshari et al (2007) or may have halted b-cell damage or reversed impaired insulin production, release, or function as suggested by West (2000).…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Ezeja

Anaga

Asuzu

2014

Pharmaceutical Biology

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Context: Gouania longipetala Hemsl. (Rhamnaceae) is used in folkloric medicine for treating diabetes mellitus and its associated symptoms. Objective: This study evaluated the antidiabetic antilipidemic and antioxidant activities of the plant methanol leaf extract. Materials and methods: Diabetes was induced in rats by intraperitoneal injection of alloxan monohydrate (160 mg/kg). Three test doses (50, 100, and 150 mg/kg) of G. longipetala extract (GLE) were administered orally and the effects were compared with glibenclamide (2 mg/kg). The effect of GLE on hyperglycemia and sub-acute study for 21 d were carried out using its effect on fasting blood sugar (FBS) level. Serum biochemistry and antioxidant activity were evaluated. Histopathological evaluation of the pancreas was also done. Results: The LD 50 of G. longipetala was found to be 44000 mg/kg. The extract significantly (p50.0001) decreased the FBS levels of treated rats from 16.2 ± 2.03 to 6.5 ± 1.52 mM/L at 150 mg/kg within 24 h. The extract decreased FBS levels of rats by 62.0, 74.8, and 75.0% on day 21 at 50, 100, and 150 mg/kg, respectively. GLE reduced the level of malondiadehyde from 23.0 ± 1.34 to 10.3 ± 0.43 mg/dL, increased superoxide dismutase activities from 2.97 ± 0.34 to 5.80 ± 0.53 IU/L at 150 mg/kg, and improved the serum lipid profile of treated rats. GLE also caused restoration of the altered histopathological changes of the pancreas. Discussion and conclusion: Gouania longipetala demonstrated significant antidiabetic, antilipidemic, and antioxidant activities that may be due to its multiple effects involving both pancreatic and extra-pancreatic mechanisms.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Ezeja

Anaga

Asuzu

2014

Pharmaceutical Biology

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“…The present study reveals that ginger supplementation cause improvement adiponectin and biomarkers related to oxidative stress, as compared to before the supplementation period and compared to placebo group. Zingiber officinale, commonly known as ginger, is traditionally used as a spice in various foods and beverages in a wide variety of ailments such as; asthma, diabetes, nausea and pain (Afshari et al, 2007). Also, Habib et al (2008) reported that ginger might act as an anti-inflammatory and anti-cancer (Habib et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…In Asian countries, ginger has also been used as an herbal medicine to treat a wide range of disorders such as inflammation, dyspepsia, nausea, vomiting, pain, the common cold and diarrhoea (Ling et al, 2010). Ginger extract has antioxidant properties and scavenges superoxide anion and hydroxyl radicals (Afshari et al, 2007). Furthermore, earlier studies have indicated that ginger possess anticancer and anti-inflammatory effects.…”

Section: Change In Adiponectin and Oxidative Stress After Modifiable mentioning

confidence: 99%

“…In contrast, antiinflammatory compounds such as ginger may ameliorate the adipocyte dysfunction associated with metabolic syndrome by inhibiting the downregulation of the adiponectin expression (Yasuka et al, 2008). In addition, ginger has been shown to be effective at inhibiting the expression of inflammatory mediators, inducible nitric oxide synthase (Afshari et al, 2007). However, little research is available to our understanding about the efficacy of oral ginger on adiponectin/and biomarkers related to oxidative stress (malondialdehyde, nitric oxide, glutathione peroxidase) in obese women with breast cancer.…”

Section: Change In Adiponectin and Oxidative Stress After Modifiable mentioning

confidence: 99%

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Change in Adiponectin and Oxidative Stress after Modifiable Lifestyle Interventions in Breast Cancer Cases

Karimi

Roshan²

2013

Asian Pacific Journal of Cancer Prevention

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Background: Breast cancer is one of the most frequent diseases in women today. Little information exists on modifiable lifestyle factors including effects of ginger supplements (as an anti-oxidant and anti-inflammatory herbal) and water-based exercise on biomarkers related to oxidative stress such as malondialdehyde (MDA), nitric oxide (NO) and glutathione peroxidase (GPx) and adiponectin in obese women with breast cancer. The aim of this study was to determine the single and concomitant effect of 6-wks water-based exercise and oral ginger supplement on the aforesaid markers in obese women with breast cancer. Materials and Methods: Forty women diagnosed with breast cancer (48±5.4 years, 76±9 kg, fat mass 41.8±4%), volunteered to participate in the study. Subjects were randomly assigned into four groups; placebo, water-based exercise, ginger supplement and water-based exercise+ginger supplement groups. Subjects in the ginger supplement group and the water-based exercise+ginger supplement group orally received 4 capsules (each capsule contained 750 mg), 7 days a week for 6 weeks. The water-based exercise program featured progressive increase in intensity and time, ranging from 50% to 75% of heart rate reserve, in a pool with 15 meters width, 4 times a week for 6 weeks. Fasting blood samples were collected at pre-test and post-test time points. Results: The ginger supplementation and or the water-base exercise resulted in an increase of adiponectin, NO and GPx and reduction MDA, as compared to pre-test values. However, the combined intervention (water-base exercise and ginger supplement) group showed significantly a far better effect on the biomarkers related to oxidative stress and adiponectin levels, as compared to the waterbase exercise or ginger supplement alone groups and the age-matched placebo group. Conclusions: Our results revealed that water-base exercise is a non-drug therapeutic strategy to reduce systemic stress in obese women suffering from breast cancer. Further, ginger supplementation alone or in combination with training, also play an important role in the pathogenesis of oxidative stress in obese women diagnosed with breast cancer.

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“…The biochemical enzymes, SOD, CAT and GPx, are the preventive antioxidants, while uric acid, vitamin C, GSH, albumin, vitamin E are the major chain breaking antioxidants [39,43,44]. Scientific studies have shown that ginger reduces the oxidative stress induced by various hepatotoxins by increasing the activity/levels of the antioxidant enzymes [8,45,46], and this mechanism would have played a cardinal role in the observed hepatoprotective effects of ginger against diverse class of toxicants.…”

Section: Ginger Enhances Antioxidant Defense Systems In Vivomentioning

confidence: 99%

Ginger Protects the Liver against the Toxic Effects of Xenobiotic Compounds: Preclinical Observations

Haniadka¹,

Saxena²,

Shivashankara³

et al. 2013

J Nutr Food Sci

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According to the World Health Organization, chronic liver disease is a major ailment and causes significant morbidity and mortality in both western and developing countries. However, till date no ideal hepatoprotective agents are available in the modern system of medicine to effective prevent and cure liver ailments. This has necessitated the need to depend on complementary and alternative systems of medicine for liver ailments and diseases. Zingiber officinale Roscoe commonly known as ginger is arguably one of the most commonly used spice, and is an integral part of our diet. In addition to its dietary use, ginger is also reported to possess myriad health benefits, and has been used in the various traditional and folk systems of medicine to treat various ailments and illnesses. Preclinical studies carried out in the past decade have shown that ginger possesses hepatoprotective effects, and to protect against diverse xenobiotic compounds like alcohol, acetaminophen, fungicides, tetracycline, heavy metals and organophosphorus compounds. Mechanistic studies have shown that the protective actions are mediated through free radical scavenging, antioxidant, cytoprotective, and to modulate the levels of the detoxifying enzymes. This review for the first time summarizes the results related to the beneficial properties of ginger in ameliorating the toxic effects of hepatotoxins, and also emphasizes the aspects that warrant future research to establish its activity and utility as a broad spectrum hepatoprotective agent.

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The effect of ginger on diabetic nephropathy, plasma antioxidant capacity and lipid peroxidation in rats

Cited by 141 publications

References 36 publications

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Antidiabetic, antilipidemic, and antioxidant activities ofGouania longipetalamethanol leaf extract in alloxan-induced diabetic rats

Change in Adiponectin and Oxidative Stress after Modifiable Lifestyle Interventions in Breast Cancer Cases

Ginger Protects the Liver against the Toxic Effects of Xenobiotic Compounds: Preclinical Observations

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