The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus

Arablou, Tahereh; Aryaeian, Naheed; Valizadeh, Majid; Sharifi, Faranak; Hosseini, Agha Fatemeh; Djalali, Mahmoud

doi:10.3109/09637486.2014.880671

Cited by 171 publications

(136 citation statements)

References 24 publications

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“…Mahluji et al (16) showed that serum triglyceride concentration reduced significantly after a 2-month supplementation of diabetic patients with 2 g/day ginger. Arablou et al (15) indicated that daily administration of 1,600 mg ginger to patients with diabetes type 2 for 12 weeks significantly decreased serum triglyceride concentration. However, Bordia et al (31) reported that daily administration of ginger to patients with coronary artery disease in doses of 4 or 10 g for 3 months did not affect serum triglyceride concentration.…”

Section: Resultsmentioning

confidence: 99%

“…Some studies have shown that ginger consumption could reduce serum triglyceride, total cholesterol, and LDL-C in patients with diabetes type 2 (15)(16)(17). According to the literature, such studies have not been performed on PD patients.…”

mentioning

confidence: 99%

“…The minimum sample size estimation for each group was 18 at a power (1-β) of 80% and α = 0.05 for a 2-arm parallel study with 2-tailed testing to detect a difference of 80 mg/ dL (0.9 mmol/L) in serum triglyceride concentration with a pooled standard deviation of 88 mg/dL (0.99 mmol/L), obtained from Arablou et al's study (15 …”

Section: Subjects and Ethical Aspectsmentioning

confidence: 99%

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Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

et al. 2016

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♦ Background: In peritoneal dialysis (PD) patients, one of the major risk factors for cardiovascular disease is lipid abnormalities. This study was designed to investigate the effects of ginger supplementation on serum lipids and lipoproteins in PD patients. ♦ Methods: In this randomized, double-blind, placebo-controlled trial, 36 PD patients were randomly assigned to either the ginger or the placebo group. The patients in the ginger group received 1,000 mg ginger daily for 10 weeks, while the placebo group received corresponding placebos. At baseline and at the end of week 10, 7 mL of blood were obtained from each patient after a 12-to 14-hour fast, and serum concentrations of triglyceride, total cholesterol, low density lipoprotein-cholesterol (LDL-C), high density lipoproteincholesterol (HDL-C), and lipoprotein (a) [Lp (a)] were measured. ♦ Results: Serum triglyceride concentration decreased significantly up to 15% in the ginger group at the end of week 10 compared with baseline (p < 0.01), and the reduction was significant in comparison with the placebo group (p < 0.05). There were no significant differences between the 2 groups in mean changes of serum total cholesterol, LDL-C, HDL-C, and Lp (a). ♦ Conclusion: This study indicates that daily administration of 1,000 mg ginger reduces serum triglyceride concentration, which is a risk factor for cardiovascular disease, in PD patients.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Section: Subjects and Ethical Aspectsmentioning

confidence: 99%

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Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

et al. 2016

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“…In a double-blinded, placebo-controlled clinical trial, 70 type 2 diabetic patients consumed 1600 mg ginger versus 1600 mg wheat flour placebo daily for 12 weeks. Ginger reduced fasting plasma glucose, HbA1C, insulin, HOMA, triglyceride, total cholesterol, CRP, and PGE2 significantly compared with the placebo group; there were no significant differences in HDL, LDL, and TNFa between the two groups [102]. In another study 3 g of dry ginger powder given to diabetic patients for 3 months and compared to a control showed significant effects at the end of the treatment on fasting blood glucose (10.5% decrease), HbA1c, and the quantitative insulin sensitivity check index (QUICKI).…”

Section: Further Clinical Studies On Ginger Are Neededmentioning

confidence: 98%

Zingiber officinale (Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

Roufogalis

2014

New Journal of Science

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Diabetes is reaching pandemic levels in both developing and developed countries and requires safe, affordable, and effective therapies. This report summarises work in our laboratory on the effects of Zingiber officinale (ginger) and its components in diabetes models and provides a future outlook on the potential for their use in type 2 diabetes. A high fat diet rat model showed modulation of body weight gain and normalisation of glucose and lipid metabolic disturbances, with reduction of insulin resistance in a high fat-high carbohydrate diet model. Ginger extract inhibits enhanced NF-B in liver of high fat-fed rats through inhibition of the IKK/I B /NF-B classical pathway. The major active component (S) -[6]-gingerol inhibited elevated cytokines in inflamed HuH-7 cells through suppression of COX2 expression and protection against the ROS pathway. Ginger extract and gingerols enhanced glucose uptake in L6 myotubes, by enhancing translocation of GLUT4 to the surface membrane and activation of AMPK 1 through a Ca 2+ /calmodulin-dependent protein kinase kinase pathway. (S)-[6]-Gingerol also enhanced energy metabolism through marked increment of peroxisome proliferator-activated receptor-coactivator-1 (PGC-1 ) gene expression and mitochondrial content in L6 skeletal muscle cells. Future studies will require well designed clinical trials on ginger preparations of defined chemical composition.

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“…The plants used in this study have been shown to be safe to use up to doses as large as 1gram [38][39][40][41] . Giving such high doses chronically may however have dire consequences.…”

Section: Discussionmentioning

confidence: 99%

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2017

IJPSR

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Background: Diabetes poses a burden on the limited health care delivery system. Current pharmacological anti-diabetic agents cause undesirable side effects and are very expensive. Herbal remedies offer the potential for alternative treatment strategies. This study was therefore conducted in an effort to formulate a poly herbal medicine for management of diabetes. Methods: A stenophylla root bark was extracted with aqueous ethanol (70%) and quantitative analysis for total phenolic content, total alkaloids and flavonoids was carried out on the dried extract. The hypoglycaemic effects of aqueous A. stenophylla root bark extract, powdered Zingiber officinale and powdered Citrus Limon peels was determined on alloxan-induced diabetic rats singly and in combinations over 14 days. Glibenclamide administered at 0.2 mg/kg b. wt was used as the positive control. Results: All the plants decreased plasma glucose levels in a dosedependent manner. The glucose levels of diabetic rats treated with all the plants combined showed the greatest reduction (59.2%). A. stenophylla and Z. officinale showed a glucose level reduction of 47.7%, A. stenophylla and C. limon (42.9%) whilst Z. officinale and C. limon (42.7%). The reductions in glucose levels were comparable to glibenclamide positive control which showed a 61% reduction. Conclusion: Combining the three plants (A. stenophylla, Z. officinale and C. limon) led to the greatest reduction in blood glucose levels of alloxan induced diabetic rats. The formulation demonstrates more potential in combinational herbal medicines therapy in diabetes management.

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The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus

Abstract: Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients. Therefore ginger can be considered as an effective treatment for prevention of diabetes complications.

Cited by 171 publications

References 24 publications

Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

Zingiber officinale (Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

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