The Effect of Geraniol on Liver Regeneration Αfter Hepatectomy in Rats

Canbek, Mediha; Uyanoğlu, Mustafa; Canbek, Selçuk; Ceyhan, Emre; Özen, Ahmet; Durmuş, Başak; Turgak, Ozge

doi:10.21873/invivo.11047

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…In normal condition, hepatocytes and cholangiocytes stay in the G0 phase of the cell cycle and indicate minimal turnover, but in response to various stimulations such as toxic injury, infections, and LR, they proliferate to compensate for the lost cells, a process called liver regeneration [3,4]. Although the precise mechanism of liver regeneration is not well understood, extensive data from the literature have demonstrated that the immune system plays an important role in the initiation and termination of liver regeneration through pro-and anti-in ammatory mediators such as cytokines, complement, and chemokines [5,6].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Liver resection promotes (regulates) pro-inflammatory cytokines in patients with hepatocellular carcinoma

Fathi

Sanei

Hakemi

et al. 2021

Preprint

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Objective: Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery is designed to remove cancerous tumors from liver. This study investigated how the expressions and serum levels of some pro- and anti-inflammatory cytokines in patients with hepatocellular carcinoma (HCC) were changed during LR.Liver tissues from 15 patients with HCC were collected and the levels of interleukin-6 (IL-6), tumornecrosis factor-alpha (TNF-α), IL-1α, IL-1 β, IL-10, and transforming growth factor- beta1 (TGF-β1) were assessed using real-time PCR assay at different times before and after LR. The serum values of TNF-α and IL-6 were also measured by ELISA.Results: After 60 and 90 minutes of LR, IL-6 gene expression was significantly increased (P < 0.001-0.05). The same trend was also observed in TNF-α expression after 90 minutes of LR (P <0.01). No significant changes were observed in the expressions of IL-1α, IL-1β, IL-10, and TGF-β1 before and after LR. In addition, LR had significant effects on TNF-α and IL-6 serum levels (P<0.05-0.0001). Our data provided further evidence to reveal that IL-6 and TNF-α cytokines are critical to improve liver regeneration.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Liver resection promotes (regulates) pro-inflammatory cytokines in patients with hepatocellular carcinoma

Fathi

Sanei

Hakemi

et al. 2021

Preprint

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“…Geraniol is another monoterpenoid valuable for the liver. This has shown regenerative effect in rats after partial hepatectomy . Eucalyptol and α ‐pinene, main monoterpenes of rosemary essential oil, according to Rašković, also exert hepatoprotective effects by diminishing AST and ALT activities …”

Section: Other Natural Monoterpene Biological Activitiesmentioning

confidence: 99%

Natural Monoterpenes: Much More than Only a Scent

Wojtunik-Kulesza

Kasprzak

Oniszczuk

et al. 2019

Chemistry & Biodiversity

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Terpenes are a widespread group of secondary metabolites that can be found in various family plants such as the Lamiaceae. In view of their numerous valuable biological activities, the industrial production of concrete terpenes and essential oils rich in the substances is intensively studied. Monoterpenes constitute a significant part of the whole group of the aforementioned secondary metabolites. This is due to their numerous biological activities and their ability to permeate the skin. Despite the fact that these substances have gain popularity, they are not comprehensively characterized. The presented review is based on studies of the biological activities of the most important monoterpenes and the essential oils rich in these compounds. The authors focused attention on antioxidant activity, inhibition towards acetyl-and butyrylcholinesterase, and α-amylase and α-glucosidase, antifungal, hepatoprotective, sedative properties, and their skin permeation enhancement.

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“…According to hematoxylin and eosin staining and PCR results, GE exhibits a hepatoprotective effect in rats after a 70 % PH, as intraperitoneal administration of GE promoted liver tissue regeneration via improving the expression levels of TNF-α and IL-6. Also, GE remarkably suppressed the ALT level in serum, which regulates the function recovery of liver cells [47]. GE is a natural compound remarkably stimulating liver regeneration as shown in the rat model with a PH that was injected with GE 100 mg/kg.…”

Section: Antimicrobial Activitymentioning

confidence: 90%

Pharmacological Properties of Geraniol – A Review

et al. 2018

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Geraniol is an acyclic isoprenoid monoterpene isolated from the essential oils of aromatic plants including Cinnamomum tenuipilum, Valeriana officinalis, and several other plants. The limited source of geraniol from plant isolation cannot fulfill the great demand from the flavor and fragrance industries, which require maximizing geraniol production through biotechnology processes. The diverse activities of geraniol suggested that geraniol could treat various diseases as a promising drug candidate. In order to evaluate the potential of geraniol applied in a clinical trial, this review aims at providing a comprehensive summary of the pharmacological effects of geraniol. The publications retrieved from PubMed, ScienceDirect, Springer, and Wiley databases were collected and summarized for the last 6 years. Then, the potential application of geraniol as a drug is discussed based on its pharmacological properties, including antitumor, anti-inflammatory, antioxidative, and antimicrobial activities, and hepatoprotective, cardioprotective, and neuroprotective effects. Hence, this review aims at providing evidence of the pharmacological activities of geraniol in the context of further development as a drug candidate in clinical application.

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The Effect of Geraniol on Liver Regeneration Αfter Hepatectomy in Rats

Cited by 15 publications

References 23 publications

WITHDRAWN: Liver resection promotes (regulates) pro-inflammatory cytokines in patients with hepatocellular carcinoma

WITHDRAWN: Liver resection promotes (regulates) pro-inflammatory cytokines in patients with hepatocellular carcinoma

Natural Monoterpenes: Much More than Only a Scent

Pharmacological Properties of Geraniol – A Review

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