The effect of genetic variations on ribavirin pharmacokinetics and treatment response in HCV-4 Egyptian patients receiving sofosbuvir/daclatasvir and ribavirin

Abdelkawy, Khaled; El-Haggar, Sahar Mohamed; Ziada, Dina Hazem; Ebaid, N.F.; El-Magd, Mohammed A.; Elbarbry, Fawzy

doi:10.1016/j.biopha.2019.109657

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…Liver damage constitutes one of the main causes of hepatocellular carcinoma (HCC) that leads to death worldwide 1 – 3 . Hepatitis is one of earlier signs of liver damage, which is characterized by inflammatory cells infiltration, congestion of blood vessels, and cellular degenerative changes.…”

Section: Introductionmentioning

confidence: 99%

“…Hepatitis is one of earlier signs of liver damage, which is characterized by inflammatory cells infiltration, congestion of blood vessels, and cellular degenerative changes. Hepatitis could be induced by a viral infection, microbial metabolites, metabolic and autoimmune diseases, environmental toxicants, and alcohol and drug abuse 1 , 3 , 4 . If hepatitis was left for a long time without suitable treatments, other complicated liver disorders such as fibrosis and cirrhosis would be developed and in advanced cases become risk factors for HCC 5 .…”

Section: Introductionmentioning

confidence: 99%

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Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats

Mohamed

El-Magd

El-Said

et al. 2021

Sci Rep

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Hepatitis is one of earlier, but serious, signs of liver damage. High doses of statins for a long time can induce hepatitis. This study aimed to evaluate and compare the therapeutic potential of thymoquinone (TQ) and bee pollen (BP) on fluvastatin (F)-induced hepatitis in rats. Rats were randomly divided into: group 1 (G1, control), G2 (F, hepatitis), G3 (F + TQ), G4 (F + BP), and G5 (F + TQ + BP). Single treatment with TQ or BP relieved fluvastatin-induced hepatitis, with best effect for the combined therapy. TQ and/or BP treatment significantly (1) reduced serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase, and total bilirubin, (2) decreased malondialdehyde levels and increased level of reduced glutathione, and activities of glutathione peroxidase and catalase in the liver, (3) improved liver histology with mild deposition of type I collagen, (4) increased mRNA levels of transforming growth factor beta 1, nuclear factor Kappa B, and cyclooxygenase 1 and 2, and (5) decreased tumor necrosis factor alpha and upregulated interleukin 10 protein in the liver. These data clearly highlight the ability of TQ and BP combined therapy to cause better ameliorative effects on fluvastatin-induced hepatitis than individual treatment by each alone.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats

Mohamed

El-Magd

El-Said

et al. 2021

Sci Rep

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“…In this study, we finalized the relevant gene "KRT23 ULBP2 ASRGL1 SERPINA1 SCIN SLC28A2" that may affect Th-17 cells immune infiltration in COAD patients. We have now found that these genes are involved in the development of many diseases (42)(43)(44)(45)(46)(47)(48)(49),In non-gastrointestinal tumors, ASRGL1 has shown a high correlation in the prognosis of patients with locally advanced lymph node-negative prostate cancer and cervical cancer (42,50); SLC28A2 helps increase the role of ribavirin (RBV) in the treatment of viral hepatitis Hyperuricemia (HUA) has been implicated (48,51). KRT23 was identified as a specifically expressed gene in colorectal cancer and highly expressed in colorectal cancer (45).…”

Section: Discussionmentioning

confidence: 99%

Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers

Zhou

et al. 2020

Preprint

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Background Colorectal cancer (CRC) is the most common type of gastrointestinal malignant tumor. Colorectal adenocarcinoma (COAD) is the most common type of colorectal cancer, and it is extremely harmful to human life and health. In recent years, the role of the immune system in the development of tumor-associated inflammation and cancer has received increasing attention. Results In this study, we compiled the expression profiles of 262 patients with complete follow-up data from the Cancer Genome Atlas (TCGA) database as an experimental group and selected 65 samples from the GEO dataset (of which M0 totaled 46 samples). Validated as a verification group. First, we screened the immune cell Th-17 cells related to the prognosis of COAD disease, and then identified the Th-17 cells-related hub genes by constructing co-expression network analysis (WGCNA) and lasso regression analysis (LASSO), which determined that it may be related to Th-17 cells. Six genes associated with prognosis in patients with COAD:”KRT23 ULBP2 ASRGL1 SERPINA1 SCIN SLC28A2”. Finally, we constructed a clinical prediction model and analyzed the predictive power of the model. These hub genes have been shown to be involved in the development of many diseases and are closely linked to digestive diseases. Our results suggest that the hub gene may influence the prognosis of COAD by regulating the immune infiltration of Th-17cells. Conclusions These newly discovered hub genes help to understand the mechanisms of COAD development and metastasis, thereby promoting the development of COAD and providing new therapeutic targets and biomarkers for COAD.

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“…The first study found that genetic variations in the ABCB1 and ABCB11 genes were associated with ribavirin (RBV) plasma trough levels and clinical outcomes, such as sustained virological response (SVR), in Egyptian patients with HCV genotype 4. The study authors concluded that genetic testing for these genes could help to personalize treatment for patients with HCV genotype 4 [16]. The second study found that sofosbuvir/ribavirin (SOF/RBV) was effective and welltolerated in most Korean patients with HCV genotype 2 (HCV GT2) infection, with an SVR12 rate of 92.8%.…”

Section: Effectiveness and Safety Of Sofosbuvir In Combination With R...mentioning

confidence: 99%

The Quest for Optimal Therapy: Sofosbuvir and Ribavirin in Chronic Hepatitis C - A Systematic Review

Monica Devi Yerramsetti,

Olawale O Olanisa,

Payal Jain

et al. 2023

Journal For International Medical Graduates

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The effect of genetic variations on ribavirin pharmacokinetics and treatment response in HCV-4 Egyptian patients receiving sofosbuvir/daclatasvir and ribavirin

Cited by 9 publications

References 43 publications

Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats

Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats

Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers

The Quest for Optimal Therapy: Sofosbuvir and Ribavirin in Chronic Hepatitis C - A Systematic Review

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