The effect of genetic variations in the choline acetyltransferase
gene (ChAT) on waterpipe tobacco smoking dependence

Khabour, Omar F.; Abu-Eitah, Rawan N; Alzoubi, Karem H.; Abu-Siniyeh, Ahmed; Eissenberg, Thomas

doi:10.18332/tid/118233

Cited by 2 publications

(3 citation statements)

References 32 publications

(44 reference statements)

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“…This could explain that shisha smoking might lead to the development of serious diseases, consistent with a report that showed that smoking of shisha has an association with the incidence of bladder cancer (Goerlitz et al 2014 ). Also, a recent study proved the significant effect of waterpipe tobacco smoking on choline acetyltransferase gene polymorphism (Khabour et al 2020 ). Therefore, waterpipe tobacco smoking could impact gene variation and result in disease progression (Kudhair et al 2020 ).…”

Section: Discussionmentioning

confidence: 96%

Human beta-defensin-1 rs2738047 polymorphism is associated with shisha smoking risk among Saudi population

Almutairi

et al. 2021

Environ Sci Pollut Res

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Human β-defensin (HBD), a member of the antimicrobial peptides, is essential for respiratory epithelial cells’ microbial defense, and is affected by cigarette smoking (CS). Its expression is upregulated by stimulation from microbes or inflammation. Genetic polymorphisms in the HBD-1 gene have been implicated in the development of various smoking-related diseases, including chronic obstructive pulmonary disease and asthma. Thus, we sought to analyze possible associations between HBD-1 single-nucleotide polymorphism (SNP) in HBD-1 gene and CS in ethnic Saudi Arabian subjects. Variants rs1047031 (C/T), rs1799946 (C/T), rs2738047 (C/T), and rs11362 (C/T) were investigated by genotyping 575 blood specimens from males and females, smokers/non-smokers: 288/287. The CT and CT+TT genotypes of rs1799946 presented an ~5-fold increased correlation with CS among the female smokers, compared with the female controls (OR = 5.473, P = 0.02003; and OR = 5.211, P = 0.02028, respectively), an observation similar to rs11362 SNP in female smokers, but with protective effects in TT genotype, compared with the CC reference allele (OR = 0.143, P = 0.04368). In shisha smokers, the heterozygous CT and the CT/TT genotype of rs2738047 polymorphism showed the same results with ~3-fold increased correlation with CS (OR = 2.788; P = 0.03448), compared with the cigarette smokers category. No significant association was shown in genotypic distributions and allelic frequencies of rs1047031. Further investigations, including large study samples, are required to investigate the effects of shisha on human beta-defensin expression and protein levels.

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Section: Discussionmentioning

confidence: 96%

Human beta-defensin-1 rs2738047 polymorphism is associated with shisha smoking risk among Saudi population

Almutairi

et al. 2021

Environ Sci Pollut Res

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“…The waterpipe dependence score was obtained using the Lebanon Waterpipe Dependence Scale-10J (LWDS-10J) as previously described (Alzoubi et al, 2013;Primack et al, 2014;Khabour, Abu-Eitah, Alzoubi, Abu-Siniyeh, & Eissenberg, 2020). Smokers were divided into less dependent and more dependent smokers based on their LWDS score (!…”

Section: Waterpipe Dependence Scorementioning

confidence: 99%

“…DNA was isolated using DNA extraction kits (Promega, Madison, WI, USA) as previously described (Alzoubi et al, 2013;Khabour et al, 2020;Sabi et al, 2020). After extraction, the quality and quantity of the isolated DNA were assayed using Bio-Rad SmartSpect_3000 device (Hertfordshire, UK).…”

Section: Isolation Of Genomic Dnamentioning

confidence: 99%

The CHRNA5 polymorphism (rs16969968) and its association with waterpipe smoking addiction among Jordanians

Al-Omoush

Alzoubi

Khabour

et al. 2020

Arab Journal of Basic and Applied Sciences

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Waterpipe smoking is a form of tobacco use that causes nicotine/tobacco dependence and has become a global health problem. In this study, the association of rs16969968 SNP in the CHRNA5 gene with waterpipe dependence was investigated. A total of 386 men and women who used a waterpipe to smoke tobacco were recruited and divided into less dependent and more dependent smokers based on their score on the Lebanon Waterpipe Dependence Scale (LWDS). Results showed a significant difference in the distribution of GG, GA, and AA genotypes by waterpipe dependence status (p < .001). The more dependent group showed a higher frequency of the AA genotype than the less dependent smokers' group (38% vs. 23%, respectively). In addition, the more dependent smokers exhibited more A allele than less dependent smokers (53% vs. 37% respectively, p < .001). In conclusion, there is an association between the rs16969968 SNP and waterpipe dependence as assessed by the LWDS.

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The effect of genetic variations in the choline acetyltransferase gene (ChAT) on waterpipe tobacco smoking dependence

Cited by 2 publications

References 32 publications

Human beta-defensin-1 rs2738047 polymorphism is associated with shisha smoking risk among Saudi population

Human beta-defensin-1 rs2738047 polymorphism is associated with shisha smoking risk among Saudi population

The CHRNA5 polymorphism (rs16969968) and its association with waterpipe smoking addiction among Jordanians

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