The effect of genetic variability (degree of homozygosity) on serum levels of the anterior pituitary hormones prolactin, corticotropin, and growth hormone in rats

Kosowska, Barbara

doi:10.1007/bf02399808

Cited by 1 publication

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References 20 publications

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“…Consequently, oCRF DOSE was also included as a candidate predictor in the model. Since the kinetics of HPA axis activity are poorly understood, and because numerous studies indicate that various aspects of HPA axis function may best fit quadratic or higher-order polynomial functions (Hanada et al, 1985;Kemppainen et al, 1986;Dellwo and Beauchene, 1990;Coppinger et al, 1991;Kosowska, 1992;Apple et al, 1993;Kling et al, 1993), we included squared and cubed polynomials of each candidate predictor in addition to product interaction terms between each of the primary predictors in the model. To eliminate the inherent tendency for multicollinearity in polynomial models, each of the candidate predictor variables was converted to an orthogonal polynomial.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid Corticotropin-Releasing Factor (CRF) and Vasopressin Concentrations Predict Pituitary Response in the CRF Stimulation Test: A Multiple Regression Analysis

Newport

Heim

Owens

et al. 2002

Neuropsychopharmacol

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There is considerable evidence that stress-related psychiatric disorders, including depression and post-traumatic stress disorder (PTSD), are associated with hypersecretion of corticotropin-releasing factor (CRF) within the central nervous system (CNS). One line of evidence that is consistent with central CRF hypersecretion in these disorders is the blunted adrenocorticotropin hormone (ACTH) response to intravenous CRF administration, likely a consequence, at least in part, of downregulation of anterior pituitary CRF receptors. The present study tests the hypothesis that elevated cerebrospinal fluid (CSF) concentrations of CRF and a secondary ACTH secretagogue, arginine vasopressin (AVP), are associated with diminished adenohypophyseal responses in a standard CRF stimulation test. CSF concentrations of CRF and AVP, and plasma ACTH responses to the administration of 1 mg/kg ovine CRF (oCRF) were measured in healthy adult women with and without current major depression and/or a history of significant childhood abuse. The primary outcome measure was ACTH area under the curve (AUC) in the CRF stimulation test. Multiple linear regression was performed to identify the impact of CSF CRF and AVP concentrations upon the pituitary response to CRF stimulation. The regression model explained 56.5% of the variation in the ACTH response to CRF stimulation. The relationship of CSF concentrations of CRF to ACTH responses to CRF were best described by a third-order function that was inversely correlated over most of the range of studied values. The association of ACTH response with CSF concentration of AVP and the dose of oCRF followed second-order kinetics. These findings support the hypothesis that central CRF hypersecretion is associated with a blunted ACTH response to exogenously administered CRF, explaining almost 60% of the variation in the ACTH response to CRF.

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