The Effect of Gencydo<sup>®</sup> Injections on Hayfever Symptoms: A Therapeutic Causality Report

Baars, Erik W.; Bruin, Anja de

doi:10.1089/acm.2005.11.863

Cited by 11 publications

(8 citation statements)

References 8 publications

(9 reference statements)

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“…The positive results of this study are in line with clinical experiences [4], in vitro studies [7, 8], and cohort studies [5, 6]. …”

Section: Discussionsupporting

confidence: 86%

“…[4]. Positive effects, without side effects, were also observed in two cohort studies: a group of 13 patients suffering from grass pollen SAR treated with subcutaneous injections [5] and a group of 140 patients, who were treated with nasal spray [6]. Recently, the immunological pathways underlying the positive effects of Citrus/Cydonia comp.…”

Section: Introductionmentioning

confidence: 98%

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Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Baars

Jong

Nierop³

et al. 2011

ISRN Allergy

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Background. Clinical experiences in vitro and clinical studies have demonstrated the curative potency and safety of Citrus/Cydonia compositum in seasonal allergic rhinitis treatment. Objectives. To compare the efficacy and safety of two routes of administration (nasal spray versus subcutaneous injections). Methodology: Design. a national, randomised, comparative clinical trial with two parallel groups. Participants. 23 patients fulfilled the study requirements. Intervention. after a one- or two-week wash-out period, 23 patients were randomized, to a 6-week treatment period. Outcomes. immunological and symptom severity changes and safety. Immunologic outcome assessments were blinded to group assignment. 23 patients were randomized and from 22/23 patients (11 in each group) blood samples were analyzed before and after treatment. Conclusion. Both routes of administration demonstrate immunological and clinical effects, with larger inflammatory and innate immunological effects of the nasal spray route and larger allergen-specific clinical effects of the subcutaneous route, and are safe.

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“…The positive results of this study are in line with clinical experiences [4], in vitro studies [7, 8], and cohort studies [5, 6]. …”

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 98%

Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Baars

Jong

Nierop³

et al. 2011

ISRN Allergy

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“…Recently, positive effects by Citrus/Cydonia comp. were obtained among a group of 13 patients with the following characteristics: (a) allergic to grass pollen, (b) suffering from hay fever, on average, for nine years, and (c) the necessity for the use of antihistamines with regard to the nature of the complaints [5]. In addition, a prospective, observational study on the effect of Citrus/Cydonia comp.…”

Section: Introductionmentioning

confidence: 99%

Citrus/Cydonia Comp. Can Restore the Immunological Balance in Seasonal Allergic Rhinitis‐Related Immunological Parameters In Vitro

Baars

Savelkoul

2008

Mediators of Inflammation

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In two in vitro studies, we examined the immunological (pathways of the) effects of Citrus/Cydonia comp. from, respectively, a healthy and an allergic donor; peripheral blood mononuclear cells (PBMCs) were isolated out of peripheral blood and analyzed in vitro after polyclonal stimulation of T-cells. The differentiation capacity and the influence with regard to Th1 (IFN-γ) and Th2 (IL-5) cells were examined. Citrus/Cydonia comp. has a selective effect on the differentiation of T-cells by producing relatively more IL-10 than IL-12. By that, it also seems to have an effect on the induction of regulatory (IL-10 producing) T-cell subsets. It is in vitro capable of neutralizing (to some extent) the changes, characteristic to allergic rhinitis, with regard to the maturation, differentiation, and activity of the immune system. Thus, Citrus/Cydonia comp. can potentially restore the disturbed immune state of rhinitis patients, which essentially could be sufficient to make allergic symptoms disappear permanently.

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“…Furthermore, the lemon and quince components had in vitro differential and synergistic anti‐allergic effects (Baars et al ., ; Huber et al ., ). So far efficacy in humans has only been investigated in two ( n = 12, n = 140) observational studies (Baars and De Bruin, ; Rother and Oexle, ) and a small ( n = 23) randomized trial comparing the nasal and subcutaneous routes of application (Baars et al ., ). Studies with an adequate control group to show efficacy (placebo control or comparison to standard treatment) have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a Nasal Spray fromCitrus limonandCydonia oblongafor the Treatment of Hay Fever Symptoms-A Randomized, Placebo Controlled Cross-Over Study

et al. 2016

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Nasal spray from lemon and quince (LQNS) is used to treat hay fever symptoms and has been shown to inhibit histamine release from mast cells in vitro. Forty-three patients with grass pollen allergy (GPA) were randomized to be treated either with placebo or LQNS for one week, respectively, in a cross-over study. At baseline and after the respective treatments patients were provoked with grass pollen allergen. Outcome parameters were nasal flow measured with rhinomanometry (primary), a nasal symptom score, histamine in the nasal mucus and tolerability. In the per protocol population absolute inspiratory nasal flow 10 and 20 min after provocation was higher with LQNS compared to placebo (-37 ± 87 mL/s; p = 0.027 and -44 ± 85 mL/s; p = 0.022). The nasal symptom score showed a trend (3.3 ± 1.8 in the placebo and 2.8 ± 1.5 in the LQNS group; p = 0.070) in favor of LQNS; the histamine concentration was not significantly different between the groups. Tolerability of both, LQNS and placebo, was rated as very good. LQNS seems to have an anti-allergic effect in patients with GPA. Copyright © 2016 John Wiley & Sons, Ltd.

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The Effect of Gencydo^® Injections on Hayfever Symptoms: A Therapeutic Causality Report

Abstract: There are clear indications that Gencydo treatment was effective in a large subgroup of the research population.

Cited by 11 publications

References 8 publications

Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Citrus/Cydonia Comp. Can Restore the Immunological Balance in Seasonal Allergic Rhinitis‐Related Immunological Parameters In Vitro

Efficacy of a Nasal Spray fromCitrus limonandCydonia oblongafor the Treatment of Hay Fever Symptoms-A Randomized, Placebo Controlled Cross-Over Study

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The Effect of Gencydo® Injections on Hayfever Symptoms: A Therapeutic Causality Report

Abstract: There are clear indications that Gencydo treatment was effective in a large subgroup of the research population.

Cited by 11 publications

References 8 publications

Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Citrus/Cydonia Compositum Subcutaneous Injections versus Nasal Spray for Seasonal Allergic Rhinitis: A Randomized Controlled Trial on Efficacy and Safety

Citrus/Cydonia Comp. Can Restore the Immunological Balance in Seasonal Allergic Rhinitis‐Related Immunological Parameters In Vitro

Efficacy of a Nasal Spray fromCitrus limonandCydonia oblongafor the Treatment of Hay Fever Symptoms-A Randomized, Placebo Controlled Cross-Over Study

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The Effect of Gencydo^® Injections on Hayfever Symptoms: A Therapeutic Causality Report