Abstract:Background:
Fixed-dose combination of artemisinin and naphthoquine (NQ) is a new artemisinin-based combination therapy for the treatment of uncomplicated Plasmodium falciparum. NQ absorption has been reported to be affected by food in human.
Objectives:
The effect of gastric pH on NQ pharmacokinetics and antiplasmodial activity was investigated. Method: The pharmacokinetic profiles of NQ were studied in healthy rodents after an oral dose of NQ with or without gastric pH modulators, i.e., pentagastrin (sti… Show more
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