The Effect of Ganglionic Blockade on Survival After Tourniquet Shock

Saltz, Nathan J.

doi:10.1001/archsurg.1960.01300040102019

Arch Surg

1960

DOI: 10.1001/archsurg.1960.01300040102019

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The Effect of Ganglionic Blockade on Survival After Tourniquet Shock

Nathan J. Saltz¹

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1964

1976

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Cited by 5 publications

(4 citation statements)

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“…It is a well documented observation that animals undergoing shock of tourniquet trauma may be resuscitated by means of replacement therapy with physiological saline [16][17]. In view of this, the substitution of sa line extracts of livers removed from animals dying in untreated tourniquet shock, as a resuscitative medium, might give some indication of the pres ence of a toxic factor, by means of a change in the recovery rate.…”

mentioning

confidence: 99%

The Liver as the Site of a Toxic Factor in Experimental Shock

Haas¹,

Saltz²

1970

Eur Surg Res

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mentioning

confidence: 99%

The Liver as the Site of a Toxic Factor in Experimental Shock

Haas¹,

Saltz²

1970

Eur Surg Res

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“…Notable amongst these are alpha adrenergic blocking agents [Wiggers et al, 1947;Lotz et al, 1955;Nickerson, 1962;Lillehei et al, 1964], ganglion blocking agents [Boba and Converse, 1957;Saltz, 1960], pressor amines [Lansing and Stevenson, 1953], and vasodilators [Hay, 1951].…”

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confidence: 99%

“…MANY substances with diverse mechanisms of action have been shown to protect the dog against the potentially lethal effects of haemorrhage. Notable amongst these are alpha adrenergic blocking agents [Wiggers et al, 1947;Lotz et al, 1955;Nickerson, 1962;Lillehei et al, 1964], ganglion blocking agents [Boba and Converse, 1957;Saltz, 1960], pressor amines [Lansing and Stevenson, 1953], and vasodilators [Hay, 1951].…”

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confidence: 99%

Effect of Isoxsuprine Hydrochloride on the Survival Rate of Dogs Subjected to Acute Blood Loss

Sharma

1968

Exp Physiol

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In dogs anæsthetized with pentobarbitone sodium, hæmorrhagic shock was produced by rapid bleeding. The blood pressure was maintained at 35 ± 5 mm. Hg for 4 hr., and then the shed blood was returned to the animal. Animals alive at the end of a 72‐hr. observation period were considered as survivors. In the control group only one out of ten dogs survived. All the animals developed severe watery diarrhœa Isoxsuprine hydrochloride 0·3 mg./kg. administered intravenously in 10 ml./kg. of normal saline 2 hr. after the onset of oligæmic hypotension increased the survival rate from 1/10 in the control group to 7/10 in the treated group. Only two dogs developed mild diarrhœa. The incidence of ventricular arrhythmias during fluid replacement was reduced from 7/10 to 2/10. However, when this drug was administered 4 hr. after the onset of oligæmic hypotension there was no improvement in the survival rate as compared to the control group but death was significantly delayed in the treated cases. The incidence of ventricular arrhythmias was reduced from 7/10 to 4/10. All the animals developed severe watery diarrhœa. The beneficial effect of isoxsuprine may be due to improved tissue perfusion resulting from vasodilatation and an increase in the volume of circulating fluids produced by the concomitant infusion of normal saline to sustain the blood pressure above 30 mm.Hg. Another factor might be the positive inotropic action of this drug. It is suggested that isoxsuprine may prove useful in the management of oligæmic shock in man.

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“…• Alpha-adrenergic (1) and ganglionic (2) blocking agents and certain vasodilators (3) are known to increase survival rates in animals subjected to standard shock procedures. These agents reduce vascular resistance and From the Department of Pharmacology, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15213.…”

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Effects of Nylidrin, Isoproterenol and Phenoxybenzamine on Dogs Subjected to Hemorrhagic Shock

Grega

Kinnard

Buckley

1967

Circulation Research

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The effects of beta-adrenergic receptor stimulants (nylidrin and isoproterenol) on the hemorrhagic shock state of anesthetized dogs were measured and compared to those of phenoxybenzamine to determine the therapeutic effectiveness of the combined cardiac stimulatory and peripheral vasodilatory actions of the former drugs. Anesthetized dogs were subjected to 3 hours of hypovolemia followed by the return of the shed blood. Nylidrin, isoproterenol (continuous infusion), and phenoxybenzamine were administered 1 hour after bleeding the animals and heart rate, arterial blood pressure, venous hematocrit, coronary blood flow, cardiac output, ventricular contractility, and survival rates were measured. Nylidrin and isoproterenol afforded significant protection against shock deaths, whereas phenoxybenzamine did not increase survival over control values. Mild to moderate intestinal hemorrhage and distention were noted in the isoproterenol-and phenoxybenzamine-treated animals, but not in the nylidrin-treated animals. Phenoxybenzamine gradually decreased the arterial blood pressure and additional quantities of blood had to be infused to maintain cardiac output and blood pressure. Ventricular contractile force progressively decreased in the phenoxybenzamine-treated animals, whereas isoproterenol and nylidrin enhanced the force of ventricular contractions. In the presence of existing hypotension, isoproterenol and nylidrin maintained cardiac output. These agents deserve further consideration as potentially useful dierapeutic agents in the management of shock states.

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The Effect of Ganglionic Blockade on Survival After Tourniquet Shock

Cited by 5 publications

References 18 publications

The Liver as the Site of a Toxic Factor in Experimental Shock

The Liver as the Site of a Toxic Factor in Experimental Shock

Effect of Isoxsuprine Hydrochloride on the Survival Rate of Dogs Subjected to Acute Blood Loss

Effects of Nylidrin, Isoproterenol and Phenoxybenzamine on Dogs Subjected to Hemorrhagic Shock

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