The Effect of Gabapentin on Postoperative Pain of Orthopedic Surgery of Lower Limb by Sciatic and Femoral Blockage in Children: A Clinical Trial

Filho, Washington Aspilicueta Pinto; Silveira, Lara de Holanda Jucá; Vale, Mariana Lima; Fernandes, Cláudia Regina; Gomes, Josenilia Alves

doi:10.5812/aapm.91207

Cited by 10 publications

(16 citation statements)

References 20 publications

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“…They exert their analgesic effects by binding to the α-2-δ subunit of voltage-dependent calcium channels. Gabapentinoids may cause sedation, respiratory depression, and altered cognition, and they possess the potential for abuse (30)(31)(32)(33)(34)(35).…”

Section: Anticonvulsantsmentioning

confidence: 99%

Conolidine: A Novel Plant Extract for Chronic Pain

et al. 2021

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: Pain, the most common symptom reported among patients in the primary care setting, is complex to manage. Opioids are among the most potent analgesics agents for managing pain. Since the mid-1990s, the number of opioid prescriptions for the management of chronic non-cancer pain (CNCP) has increased by more than 400%, and this increased availability has significantly contributed to opioid diversion, overdose, tolerance, dependence, and addiction. Despite the questionable effectiveness of opioids in managing CNCP and their high rates of side effects, the absence of available alternative medications and their clinical limitations and slower onset of action has led to an overreliance on opioids. Conolidine is an indole alkaloid derived from the bark of the tropical flowering shrub Tabernaemontana divaricate used in traditional Chinese, Ayurvedic, and Thai medicine. Conolidine could represent the beginning of a new era of chronic pain management. It is now being investigated for its effects on the atypical chemokine receptor (ACK3). In a rat model, it was found that a competitor molecule binding to ACKR3 resulted in inhibition of ACKR3’s inhibitory activity, causing an overall increase in opiate receptor activity. Although the identification of conolidine as a potential novel analgesic agent provides an additional avenue to address the opioid crisis and manage CNCP, further studies are necessary to understand its mechanism of action and utility and efficacy in managing CNCP.

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Section: Anticonvulsantsmentioning

confidence: 99%

Conolidine: A Novel Plant Extract for Chronic Pain

et al. 2021

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“…So far, there have been studies on the effects of gabapentinoids, duloxetine, dexmedetomidine, ketamine, lidocaine, magnesium, and regional blocks (11)(12)(13)(14)(15)(16)(17). Despite the advances in pain management, opioids are still commonly used to treat these conditions (18).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Perioperative Pregabalin and Duloxetine for Pain Management After Total Knee Arthroplasty: A Double-Blind Clinical Trial

Imani¹,

Emami²,

Alimian³

et al. 2023

Anesth Pain Med

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Background: Chronic residual pain after total knee arthroplasty (TKA) is one of the challenges of postoperative pain management. Duloxetine, by controlling neuropathic pain, and pregabalin, by affecting nociceptors, can effectively manage postoperative pain. Objectives: This study aimed to compare the effect of perioperative oral duloxetine and pregabalin in pain management after knee arthroplasty. Methods: In this clinical trial, 60 patients scheduled for TKA under spinal anesthesia were randomly assigned to one of three groups A (pregabalin 75 mg), B (duloxetine 30 mg), and C (placebo). Drugs were administered 90 minutes before, 12, and 24 hours after surgery. The visual analog scale (VAS) score for pain, the first analgesic request time, postoperative analgesic consumption (i.v. paracetamol), and WOMAC score six months after surgery were recorded. Results: The VAS score and analgesic consumption 48 hours after TKA in groups A and B significantly decreased compared to the placebo (P < 0.05). The first analgesic request time was longer in groups A and B than in group C (P < 0.05). While the differences were statistically significant, they are most likely not clinically significant. The WOMAC score before and six months after arthroplasty did not differ between the groups (P > 0.05). Conclusions: Perioperative oral pregabalin and duloxetine similarly reduce pain and the need for analgesic consumption within 48 hours after TKA but do not affect knee mobility status.

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“…Over the past couple of decades, gabapentin has been studied as a potential alternative for the management of postoperative pain following a variety of surgeries. [8][9][10][11][12] Prior randomized controlled trials (RCTs) have found that perioperative gabapentin, given both preoperatively and postoperatively after thoracic, orthopedic, abdominal, genitourinary, otolaryngologic, limb, or breast surgeries, resulted in improved postoperative pain, reduced total postoperative opioid consumption, and diminished opioid-related adverse effects such as vomiting and pruritus. [8][9][10][11][12] For sinonasal procedures such as endoscopic sinus surgery (ESS) and septoplasty, prior RCTs have found that gabapentin administered preoperatively resulted in reduced pain levels and opioid consumption intraoperatively or immediately after surgery.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11][12] Prior randomized controlled trials (RCTs) have found that perioperative gabapentin, given both preoperatively and postoperatively after thoracic, orthopedic, abdominal, genitourinary, otolaryngologic, limb, or breast surgeries, resulted in improved postoperative pain, reduced total postoperative opioid consumption, and diminished opioid-related adverse effects such as vomiting and pruritus. [8][9][10][11][12] For sinonasal procedures such as endoscopic sinus surgery (ESS) and septoplasty, prior RCTs have found that gabapentin administered preoperatively resulted in reduced pain levels and opioid consumption intraoperatively or immediately after surgery. [13][14][15][16][17] Most recently, a retrospective cohort study with 57 patients investigated the impact of preoperative gabapentin on postoperative pain control for 1 week after ESS and/or septoplasty.…”

Section: Introductionmentioning

confidence: 99%

Postoperative Gabapentin's Effect on Opioid Consumption and Pain Control Following Sinonasal Surgery

Yang

Suh

et al. 2022

The Laryngoscope

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Objective This study investigates the impact of postoperative gabapentin on opioid consumption and pain control following endoscopic sinus surgery (ESS) and/or septoplasty. Methods Patients who underwent ESS and/or septoplasty at a single institution from 2021 to 2022 were enrolled. All patients received postoperative hydrocodone‐acetaminophen for pain control. Half of the patients were also prescribed gabapentin for the first postoperative day in addition to hydrocodone‐acetaminophen. Subjects completed the Revised American Pain Society Patient Outcome Questionnaire 24 h and 7 days after surgery. We conducted a multivariable regression analysis to assess opioid consumption and improvement in pain scores in the first week between gabapentin and non‐gabapentin groups. Results A total of 102 subjects, 51 in each arm, were enrolled. The mean age was 52 years and 53% of participants were female. Controlling for important baseline demographic, clinical, and surgically related variables, the addition of postoperative gabapentin was associated with a 44% (9.5 mg from 21.6 mg) reduction in opioids consumed in the first postoperative week (B = −9.54, 95% C.I. = [−17.84, −1.24], p = 0.025). In addition, patients in both arms exhibited similar improvement in pain severity and sleep interference in the first 7 days (B = −1.59, 95% C.I. = [−5.03, 1.84], p = 0.36). Conclusion To the best of our knowledge, this is the first study to investigate the impact of postoperative gabapentin on opioid consumption and pain control following ESS and/or septoplasty. Our analysis demonstrated that postoperative gabapentin effectively reduced opioid use during the first postoperative week without compromising pain control. Level of Evidence 3 Laryngoscope, 133:1065–1072, 2023

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The Effect of Gabapentin on Postoperative Pain of Orthopedic Surgery of Lower Limb by Sciatic and Femoral Blockage in Children: A Clinical Trial

Cited by 10 publications

References 20 publications

Conolidine: A Novel Plant Extract for Chronic Pain

Conolidine: A Novel Plant Extract for Chronic Pain

Comparison of Perioperative Pregabalin and Duloxetine for Pain Management After Total Knee Arthroplasty: A Double-Blind Clinical Trial

Postoperative Gabapentin's Effect on Opioid Consumption and Pain Control Following Sinonasal Surgery

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