The Effect of Gabapentin and Tramadol in Cancer Pain Induced by Glioma Cell in Rat Femur

Abstract

Preclinical Research The presence of pain as part of the cancer process is variable. Glioblastoma multiform (GBM) can produce bone metastasis, a condition that involves other pathological phenotypes including neuropathic and inflammatory pain. Tramadol and gabapentin are drugs used in the treatment of neuropathic pain. However, there are no studies evaluating their analgesic effects in bone metastasis. We produced a pain model induced by the inoculation of glioma cells (10 ) into the rat femur, by perforating the intercodiloid fossa. Painful behavior was evaluated by measuring mechanical allodynia using the Von Frey test while thermal hyperalgesia was assessed in the plantar test. Histopathological features were evaluated and antinociceptive responses were compared using tramadol and gabapentin. The inoculation of cells inside the right femur produced nociceptive behaviors. Tramadol and gabapentin produced an anti-allodynic effect in this condition, but tramadol did not produce an anti-hyperalgesic response. The development of this model will allow us to perform tests to elucidate the pathology of bone metastasis, cancer pain, and in particular the pain produced by glioma. Drug Dev Res 78 : 173-183, 2017. © 2017 Wiley Periodicals, Inc.

Activation of the P2X7 receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats

“…Tramadol is used alone or in combination with other narcotics for neuropathic and inflammatory pain treatment. 32 , 58 Several investigations revealed that tramadol can alleviate BCP in rodent models and in humans 59 , 60 ; however, these studies failed to correlate the mechanism underlying the analgesic effect of tramadol on BCP with the purinergic signaling pathway. Based on the previous findings, 61 , 62 tramadol can rapidly penetrate the blood–brain barrier and blood–cerebrospinal fluid barrier.…”

Schwann cells as a target cell for the treatment of cancer pain

“…In recent years, an increasing number of drug treatments for relieving cancer pain have been discovered, such as Scorpion (Yu et al, 2020), Morin (Jiang et al, 2017), XPro1595 (a soluble tumor necrosis factor [solTNF] inhibitor) (Zhou et al, 2019), Rolipram (Guo et al, 2016), Gabapentin and Tramadol (Corona‐Ramos et al, 2017), and P2X receptor antagonists (such as BBG [Wu et al, 2022] and A‐740003 [Li et al, 2018]). All of these methods are effective in relieving cancer pain.…”