The effect of functionally graded materials on bone remodeling around osseointegrated trans-femoral prostheses

Ghaziani, Armin Omidvar; Soheilifard, Reza; Kowsar, Sara

doi:10.1016/j.jmbbm.2021.104426

Cited by 23 publications

(13 citation statements)

References 41 publications

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“…The accuracy of the analysis depends on the authenticity of the models and the validity of the loading conditions. The current study reconstructed a heterogeneous femoral model which could realistically reflect the biomechanical performance of diverse bone densities ( Saeidi et al, 2020 ; Ghaziani et al, 2021 ). Meanwhile, the accuracy of the heterogeneous model reconstruction method in this study has been demonstrated by previous biomechanical tests ( Zhang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Biomechanical Comparison Between Porous Ti6Al4V Block and Tumor Prosthesis UHMWPE Block for the Treatment of Distal Femur Bone Defects

Zhang

Liu

Han

et al. 2022

Front. Bioeng. Biotechnol.

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Purpose: The management of bone defects is a crucial content of total knee revision. This study compared the biomechanical performance of porous Ti6Al4V block and tumor prosthesis UHMWPE block in treating distal femoral bone defects.Methods: The finite element models of AORI type 3 distal femoral bone defect treated with porous Ti6Al4V block and UHMWPE block were established. Sensitivity analysis was performed to obtain the appropriate mesh size. The biomechanical performance of treatment methods in bone defects were evaluated according to the peak stress, the Von Mises stress distribution, and the average stresses of regions of interest under the condition of standing on one foot and flexion of the knee. Statistical analysis was conducted by independent samples t-test in SPSS (p < 0.05).Results: In the standing on one-foot state, the peak stress of the porous Ti6Al4V block was 12.42 MPa and that of the UHMWPE block was 19.97 MPa, which is close to its yield stress (21 MPa). Meanwhile, the stress distribution of the UHMWPE block was uneven. In the flexion state, the peak stress of the porous Ti6Al4V block was 16.28 MPa, while that of the UHMWPE block was 14.82 MPa. Compared with the porous Ti6Al4V block group, the average stress of the region of interest in UHMWPE block group was higher in the standing on one foot state and lower in the flexion state (p < 0.05).Conclusion: More uniform stress distribution was identified in the porous Ti6Al4V block application which could reserve more bone. On the contrary, uneven stress distribution and a larger high-stress concentration area were found in the UHMWPE block. Hence, the porous Ti6Al4V block is recommended for the treatment of AORI type 3 distal femoral bone defect.

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Section: Discussionmentioning

confidence: 99%

Biomechanical Comparison Between Porous Ti6Al4V Block and Tumor Prosthesis UHMWPE Block for the Treatment of Distal Femur Bone Defects

Zhang

Liu

Han

et al. 2022

Front. Bioeng. Biotechnol.

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“…Nonetheless, both internal and external bone remodelling are important to get a comprehensive overview of the remodelling process due to mechanical perturbations at the bone tissue. In addition, since the theory of SED based bone remodelling approach 64,[125][126][127][128][129] came into existence, there has not been much significant development in the remodelling approaches. However, most of the models developed henceforth are mostly subtle need-based modifications 93,95,125,[130][131][132][133][134] of the existing formulation of Huiskes and co-workers 64,85 and the Stanford model 84,92,135 of bone adaptation.…”

Section: Studies On Internal Bone Remodelling and External Bone Remod...mentioning

confidence: 99%

Application of finite element analysis to tissue differentiation and bone remodelling approaches and their use in design optimization of orthopaedic implants: A review

Ghosh

Chanda

Chakraborty

2022

Numer Methods Biomed Eng

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Post-operative bone growth and long-term bone adaptation around the orthopaedic implants are simulated using the mechanoregulation based tissuedifferentiation and adaptive bone remodelling algorithms, respectively. The primary objective of these algorithms was to assess biomechanical feasibility and reliability of orthopaedic implants. This article aims to offer a comprehensive review of the developments in mathematical models of tissuedifferentiation and bone adaptation and their applications in studies involving design optimization of orthopaedic implants over three decades. Despite the different mechanoregulatory models developed, existing literature confirm that none of the models can be highly regarded or completely disregarded over each other. Not much development in mathematical formulations has been observed from the current state of knowledge due to the lack of in vivo studies involving clinically relevant animal models, which further retarded the development of such models to use in translational research at a fast pace. Future investigations involving artificial intelligence (AI), soft-computing techniques and combined tissue-differentiation and bone-adaptation studies involving animal subjects for model verification are needed to formulate more sophisticated mathematical models to enhance the accuracy of pre-clinical testing of orthopaedic implants.

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“…The results indicated that FGMs have the potential to be effective biomaterial substitutes in producing a new generation of hip prosthetic parts that are capable of reducing stress shielding, thus increasing the longevity of the replacement and preventing the loosening of the prosthesis. Ghazianiet al, [54] propose several FGM implants and compare their bone remodelling results with the conventionally used Titanium implants by linking an FE analysis to a bone remodelling algorithm. They utilize Titanium/Hydroxyapatite (Ti/HAP) FGM implants in their study with different gradation directions and compositions.…”

Section: Biomedical Cooilacilppamentioning

confidence: 99%

A Review on Functionally Graded Materials and Their Applications in the Field of Prosthetics

Saad¹

2022

ERJ. Engineering Research Journal

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Functionally graded materials (FGMs) are special types of advanced composites with peculiar features and advantages. The main characteristic of an FGM is the gradual variation in composition and microstructure across its dimensions, resulting in enhanced properties. FGMs are consisting of two or more materials in order to achieve the desired properties according to the application where an FGM is used. As a result FGMs are of great interest for numerous applications. This paper reviews various fabrication techniques, classification and its applications in the field of prosthetics.

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The effect of functionally graded materials on bone remodeling around osseointegrated trans-femoral prostheses

Cited by 23 publications

References 41 publications

Biomechanical Comparison Between Porous Ti6Al4V Block and Tumor Prosthesis UHMWPE Block for the Treatment of Distal Femur Bone Defects

Biomechanical Comparison Between Porous Ti6Al4V Block and Tumor Prosthesis UHMWPE Block for the Treatment of Distal Femur Bone Defects

Application of finite element analysis to tissue differentiation and bone remodelling approaches and their use in design optimization of orthopaedic implants: A review

A Review on Functionally Graded Materials and Their Applications in the Field of Prosthetics

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