The effect of functional ions (Y3+, F−, Ti4+) on the structure, sintering and crystallization of diopside-calcium pyrophosphate bioglasses

Ben–Arfa, Basam A.E.; Salvado, Isabel M. Miranda; Ferreira, J.M.F.; Pullar, Robert C.

doi:10.1016/j.jnoncrysol.2016.04.028

Cited by 13 publications

(4 citation statements)

References 60 publications

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“…Meanwhile, it was reported that with an increase in the percentage of TiO 2 more than 5 mol.%, the formation of HA decreased 52 . Additionally, Ben‐Arfa et al 51 reported that all BGs with substitution of Ti displayed a quick biomineralization rate due to HA formation on the BG surface after 1 h of soaking in the SBF solution. Therefore, they showed a high bioactivity rate, and it accelerated by increasing time up to 7 days.…”

Section: Resultsmentioning

confidence: 99%

“…There have been conflicting reports so far about the effect of Ti on Ti‐incorporated silicon‐based BG. Some researchers exhibited that Ti positively affected bioactivity, biocompatibility, cell proliferation, and cell viability 51–53 . Moreover some researchers have reported that the addition of Ti reduced cell viability, or in some cases, it was not noted that the presence of 5% Ti is optimal.…”

Section: Introductionmentioning

confidence: 99%

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Characterization, in vitro bioactivity and biological studies of sol‐gel‐derived TiO₂ substituted 58S bioactive glass

Moghanian

Nasiripour

Koohfar

et al. 2021

Int J Applied Ceramic Tech

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Bioactive glasses (BGs) have been used for bone formation and bone repair processes in recent years. This study investigated the titanium substitution effect on 58S BGs (Ti‐BGs) 60SiO2‐(36 − X)CaO‐4P2O5‐XTiO2 (X = 0, 3, and 5 mol.%) prepared by the sol‐gel technique, and the main goal was to find the optimum amount of titanium in Ti‐BGs. Synthesized BGs, which were investigated after immersion in simulated body fluid (SBF), were tested by X‐ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy. Moreover alkaline phosphate (ALP) activity, 3‐(4,5dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay, and antibacterial studies were employed to investigate the biological properties of Ti‐BGs. According to the FTIR and XRD test results, hydroxyapatite (HA) formation on Ti‐BGs surfaces was confirmed. Meanwhile, the presence of 5 mol.% compared to 3 mol.% increased the HA grain distribution and their size on the Ti‐BGs surface. Additionally, MTT and ALP results confirmed that the optimal amount of titanium substitution in BG was 5 mol.%. Since 5 mol.% Ti incorporated BG (BG‐5) had the highest biocompatibility level, antibacterial properties, maximum cell proliferation, and ALP activity among the synthesized Ti‐BGs, it is presented as the best candidate for further in vivo investigations.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization, in vitro bioactivity and biological studies of sol‐gel‐derived TiO₂ substituted 58S bioactive glass

Moghanian

Nasiripour

Koohfar

et al. 2021

Int J Applied Ceramic Tech

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“…Addition of rare elements such as lanthanum, cerium, neodymium, praseodymium, and its influence on the structure of diopside was investigated [20]. The influence of adding titanium, yttrium and fluoride on the crystal structure and sinterability of diopside for its medical and bio-glass applications is reported [21]. Copper in silicate glasses has received much interest for its optical properties in the ultraviolet range and nonlinear optics [22,23].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Cu-containing Diopside through a One-Step Crystallization

et al. 2021

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The incorporation of copper into pyroxene structure was investigated through the melt quenching technique and one-step crystallization procedure. Two series of glasses have been studied, one set with Ca=Mg and another set with Ca>Mg in diopside formula Cux(Ca Mg)2-xSi2O6. The glasses were nucleated by TiO2, Cr2O3, or CaF2 additions as nucleating agents to variably control the phases produced. X-ray diffraction (XRD), scanning electron microscopy, and energy-dispersive X-ray spectroscopy (EDX) were used to characterize the obtained samples. The heat treatment studied at 700, 800, 900 and 1000 °C for 2 h produced green and dark green glasses based on Cu-containing diopside. Various crystalline wollastonite, cuprite, tenorite, cristobalite, quartz, and fluorite phases were developed with different ratios combined with diopside formation depending on the heat treatment and nucleating agents used. As the heat treatment increased in temperature, the crystallized fraction increased with the development of nano-aggregates and the observed reticulated textures confirmed a radical change in the euhedral crystals. This emphasizes that the Cu-containing diopside can be created by a facile one step process. These compositions may find some applications in biological and optical fields.

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“…Medical, biotechnology, life sciences, and optical technologies are all important applications of glasses, and glasses were introduced as a biomaterial after the discovery of bioactive glass by Hench . Since then, tremendous progress has been made using different compositions, or by using various dopant ions . Different preparation techniques have been used to synthesis glass, but melt quenching and sol‐gel are the most common techniques to synthesize glass for tissue engineering .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and bioactivity assessment of high silica content quaternary glasses with Ca: P ratios of 1.5 and 1.67, made by a rapid sol‐gel process

Ben–Arfa

Fernandes

Salvado

et al. 2017

J Biomedical Materials Res

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Sol-gel glasses in quaternary silica-sodium-calcium-phosphorous systems have been synthesized using a rotary evaporator for rapid drying without ageing. This novel fast drying method drastically decreases the total drying and ageing time from several weeks to only 1 hour, thus overcoming a serious drawback in sol-gel preparation procedures for bioglasses. This work investigates the bioactivity behavior of two glasses synthesized by this fast method, with Ca:P ratios of 1.5, and 1.67. X-ray diffraction (XRD), Inductive coupled plasma, Fourier-transform infrared, and Raman spectroscopy were used to confirm the bioactivity of the synthesized powders. MAS-NMR was also used to assess the degree of silica polymerization. The composition with a higher Ca:P = 1.67 ratio showed better bioactivity in comparison to the one with Ca:P = 1.5, which exhibited little bio-response with up to 4 weeks of immersion in SBF (simulated body fluid). It was also found that an orbital agitation rate of 120 rpm favors the interfacial bio-mineralization reactions, promoting the formation of a crystalline hydroxyapatite (HAp) layer at the surface of the (Ca:P = 1.67) composition after 2 weeks immersion in SBF. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 510-520, 2018.

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The effect of functional ions (Y3+, F−, Ti4+) on the structure, sintering and crystallization of diopside-calcium pyrophosphate bioglasses

Cited by 13 publications

References 60 publications

Characterization, in vitro bioactivity and biological studies of sol‐gel‐derived TiO₂ substituted 58S bioactive glass

Characterization, in vitro bioactivity and biological studies of sol‐gel‐derived TiO₂ substituted 58S bioactive glass

Synthesis of Cu-containing Diopside through a One-Step Crystallization

Synthesis and bioactivity assessment of high silica content quaternary glasses with Ca: P ratios of 1.5 and 1.67, made by a rapid sol‐gel process

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The effect of functional ions (Y3+, F−, Ti4+) on the structure, sintering and crystallization of diopside-calcium pyrophosphate bioglasses

Cited by 13 publications

References 60 publications

Characterization, in vitro bioactivity and biological studies of sol‐gel‐derived TiO2 substituted 58S bioactive glass

Characterization, in vitro bioactivity and biological studies of sol‐gel‐derived TiO2 substituted 58S bioactive glass

Synthesis of Cu-containing Diopside through a One-Step Crystallization

Synthesis and bioactivity assessment of high silica content quaternary glasses with Ca: P ratios of 1.5 and 1.67, made by a rapid sol‐gel process

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Characterization, in vitro bioactivity and biological studies of sol‐gel‐derived TiO₂ substituted 58S bioactive glass

Characterization, in vitro bioactivity and biological studies of sol‐gel‐derived TiO₂ substituted 58S bioactive glass