The effect of fumarate on respiration

Abstract

In t r o d u c t io n

THE EXCRETION OF l-MALIC ACID IN RELATION TO THE TRICARBOXYLIC ACID CYCLE IN THE KIDNEY*

“…In attempting to design further experiments to clarify the nature of this difference. we were reminded of the catalytic "sparking" effect of fumarate in isolated tissues oxidizing pyruvate (14,15). We wondered whether fumarate could exert a similar catalytic effect on malate reabsorption by "sparking" the oxidative energy production in the renal tubular cells.…”

Nutrition Research from Respiration and Vitamins to Cholesterol and Atherosclerosis

“…We found that the oxygen uptake of these tissues was increased by the addition of very small amounts of fumarate and that this increase was much more than could be accounted for by the oxidation of the fumarate itself. Substances that yielded fumarate on contact with tissues, such as succinate, malate, oxaloacetate, had a similar action (35).…”

“…At the end of three years of study in Europe, I returned to the University of Wisconsin as a research associate in biochemistry at the Bowman Cancer Research Institute, later to be renamed the McArdle Cancer Institute. Here, I continued research on tissue respiration with Carl Baumann who had also returned to Wisconsin (35).…”