The effect of FTO rs9939609 polymorphism on the association between colorectal cancer and dietary fiber

Abstract

BackgroundGene polymorphisms may explain the controversy on the association between colorectal cancer (CRC) and dietary fibers. The purpose of this study was to investigate the effect of fat mass and obesity-associated (FTO) rs9939609 polymorphism on the association between colorectal cancer and dietary fiber.MethodsThis case-control study was conducted on 160 CRC cases and 320 healthy controls in Tehran, Iran. The participants' food intake was assessed using a semi-quantitative food frequency questionnaire (FFQ). The frequency of rs9939609 FTO polymorphism in the case and control groups was determined using the tetra-primer amplification refractory mutation (tetra-ARMS) method.ResultsIn the participants with the TT genotype of the FTO rs9939609, the cases had higher BMI and lower intake of dietary fiber compared to the controls (P = 0.01). Among A allele carriers of FTO rs9939609 polymorphism, the cases had higher BMI (P = 0.04) and lower intake of total fiber (P = 0.02) and soluble fiber (P = 0.02). An inverse association was found between CRC and dietary fiber intake among those with the AA/AT FTO rs9939609 genotype after adjusting for age, sex, smoking, alcohol consumption, physical activity, BMI, and calorie intake (OR = 0.9, CI 95%:0.84–0.92, P < 0.05).ConclusionThis study found a link between higher dietary fiber consumption and a lower risk of CRC in A-allele carriers of FTO rs9939609 polymorphism. Future studies are needed to identify the underlying mechanisms of the association between CRC and dietary fibers in people with different FTO genotypes.

The effects of FTO gene rs9939609 polymorphism on the association between colorectal cancer and dietary intake

“…For example, one study reported a possible association between CRC with total fat, polyunsaturated fatty acids, and trans fatty acids ( 34 ). In line with the results of the present study, recent studies indicated that the association between CRC risk and dietary components can be influenced by FTO genotype ( 35 , 36 ). For example, a case–control study found an inverse association between CRC and total dietary fiber intake only among people with AA/AT FTO rs9939609 genotype ( 35 ).…”

“…In line with the results of the present study, recent studies indicated that the association between CRC risk and dietary components can be influenced by FTO genotype ( 35 , 36 ). For example, a case–control study found an inverse association between CRC and total dietary fiber intake only among people with AA/AT FTO rs9939609 genotype ( 35 ). Previous studies ( 37–40 ) have shown that dietary fiber can reduce the risk of CRC by promoting fermentation by gut bacteria as a prebiotic and producing short chain fatty acids (SCFAs) ( 37 ).…”

Az elhízás, a 2-es típusú diabetes és a daganatok közötti genetikai összefüggések egy perspektívája

“…Az eredmények az FTO rs9939609 SNP "A" (adenin) alléljának hordozóiban egyértelműen igazolták a kapcsolatot a nagyobb arányú élelmirost-fogyasztás és a colorectalis carcinoma kisebb kockázata között. A kutatók a háttérben álló patomechanizmust itt sem tudták feltárni, e célból nagyszámú és változatos FTO genotípusú alany bevonásával további vizsgálatokat javasoltak [54].…”