The effect of fraction size on control of early glottic cancer

Three weeks radiotherapy for T1 glottic cancer: the Christie and Royal Marsden Hospital Experience

“…There are data that show that fractionation schedules using doses . 2 Gy are superior to those using 1.8 Gy per fraction [20,27,43,54]. Schwaibold et al in their retrospective analysis of 58 patients found a 3-year LC of 75% in patients treated with 1.8-Gy fractions, compared with 100% in those treated with 2 Gy or above [43].…”

“…2 Gy are superior to those using 1.8 Gy per fraction [20,27,43,54]. Schwaibold et al in their retrospective analysis of 58 patients found a 3-year LC of 75% in patients treated with 1.8-Gy fractions, compared with 100% in those treated with 2 Gy or above [43]. Kim in their study of 85 patients with T1 glottic cancer reported a 2-year LC of 79% in patients treated with 1.8 Gy compared to 96% in those who received 2 Gy [20].…”

“…Treatment related parameters that may have an effect on end results include overall treatment time (OTT) [6,16,27,33,40,41,42,49,51], fraction size [20,22,29,43,54] [42]. Even with surgical salvage, the group of patients whose treatment was most prolonged had an increased risk of death from loco-regional progression of disease.…”

Management of stage II (T2N0M0) glottic carcinoma by radiotherapy and conservation surgery

“…1,5 Poor results have been obtained in T2 glottic carcinomas, at ഛ1.8 Gy per fraction, as compared with ജ2 Gy per fraction at similar total radiation doses. 1,5,26 The use of twice daily fractionation (at 1.2 Gy per fraction) for a total dose of 74.4 Gy achieved 93% local control. 4 Lesions amenable to conservation surgery that were treated by curative radiotherapy had better local control rates (83% versus 72%) than those which would have required total laryngectomy.…”

Significance of pretreatment hemoglobin level in patients with T1 glottic cancer

“…Although early stage carcinomas of the glottic larynx may be treated with either radiation therapy (RT) or surgery, radiation is most often used because it offers preservation of the voice and laryngeal structures. Reported local control rates for T1 glottic cancers range from 80%-95% [2][3][4], with surgical salvage of radiation failures increasing the overall local control to 90%-100%. [5,6] Many reports have evaluated potential host, tumor, and treatment factors for their effect on local control in early glottic carcinomas.…”