The Effect of Four Anaesthetic Protocols for Maintenance of Anaesthesia on Trans-Diaphragmatic Pressure in Dogs

Pavlidou, Kiriaki; Savvas, Ioannis; Moens, Yves; Vasilakos, D.; Raptopoulos, D.

doi:10.1371/journal.pone.0075341

Cited by 9 publications

(9 citation statements)

References 47 publications

(56 reference statements)

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“…P di value in control group was 11.62±3.54 mmHg and this finding is in accordance with the P di reference published values in our previous study (Pavlidou et al 2013). Regarding the anesthetic protocol, it was the same with the protocol (premedication, induction, maintenance) that has been used in the other two published clinical studies about P di (Pavlidou et al 2013, Pavlidou et al 2014). This anesthetic protocol seems to have a weak effect on diaphragmatic contractility.…”

Section: Discussionsupporting

confidence: 90%

“…The evaluation of diaphragmatic contractility was based on the modified technique for P di measurement with balloon catheters (Pavlidou et al 2014). P di value in control group was 11.62±3.54 mmHg and this finding is in accordance with the P di reference published values in our previous study (Pavlidou et al 2013). Regarding the anesthetic protocol, it was the same with the protocol (premedication, induction, maintenance) that has been used in the other two published clinical studies about P di (Pavlidou et al 2013, Pavlidou et al 2014).…”

Section: Discussionsupporting

confidence: 79%

“…Moreover, several pharmacological agents, such as anesthetic drugs (propofol, halothane, isoflurane) have been found to depress diaphragmatic contractility in experimental studies (Jagers et al2009;Kochi et al 1992;Nishina et al2003;Zhang et al2009). In veterinary clinical practice, the effect of four anesthetic drugs (isoflurane, fentanyl, propofol, ketamine) on diaphragmatic contractility in dogs has already been studied (Pavlidou et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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The effect of aminophylline on trans-diaphragmatic pressure in isoflurane anaesthetised dogs undergoing castration

Pavlidou

Savvas

Moens

et al. 2018

J Hellenic Vet Med Soc

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ABSTRACT. The trans-diaphragmatic pressure (P di )is the main indicator of diaphragmatic contractility and the influence of many different drugs on P di has already been studied. The main aim of this study was to investigate the effect of aminophylline on P di in anaesthetised dogs. Eighteen, healthy, client-owned, male dogs undergoing castration were recruited in the study. All the animals were premedicated with dexmedetomidine and morphine. Anesthesia was induced with propofol to effect and maintained with isoflurane in oxygen. Animals were randomly allocated into two groups. In the animals of the aminophylline group (group A), aminophylline was administered as an intravenous bolus at 4mg/kg after induction, whereas in the animals of the control group (group C), no aminophylline was given. When the surgical plane of anesthesia was achieved, two balloon catheters, one in the stomach and one in the mid-third of the oesophagus were inserted for P di measurement. The two groups differed non-significantly with regards to P di (p=0.182). The results of the study could be viewed as an indication that the aminophylline might increase diaphragmatic contractility if also proven in a larger population of animals'.Keywords: diaphragm, trans-diaphragmatic pressure, oesophageal balloon catheters, dog ΠΕΡΙΛΗΨΗ. Η δια-διαφραγματική πίεση (P di ) είναι ο κύριος δείκτης της συσπαστικότητας του διαφράγματος και η επίδραση αρκετών διαφορετικών φαρμάκων σε αυτήν έχει μελετηθεί. Ο κύριος στόχος αυτής της μελέτης είναι να μελετηθεί η επίδραση της αμινοφυλλίνης στη P di σε σκύλους υπό αναισθησία. Σε αυτή την μελέτη συμπεριλήφθηκαν δεκαοχτώ, υγιείς, ιδιόκτητοι, αρσενικοί σκύλοι οι οποίοι υποβλήθηκαν σε ορχεκτομή. Η προαναισθητική αγωγή σε όλα

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of aminophylline on trans-diaphragmatic pressure in isoflurane anaesthetised dogs undergoing castration

Pavlidou

Savvas

Moens

et al. 2018

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

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“…As the animals were critically ill patients, the anaesthetic protocol could not be the same for all of them. In each case, the anaesthetic protocol was based on the clinical condition of the animal and it was selected in a way to minimally affect the P di (Pavlidou et al, 2013). Specifically, the premedication differed among the animals, whereas the induction and the maintenance of anaesthesia was the same in all animals.…”

Section: Methodsmentioning

confidence: 99%

“…There are few available data for the measurement of P di in veterinary practice, as the most studies were "in vitro" and the diaphragmatic contractility was evaluated after the electrical stimulation of the phrenic nerves. However, there are two recent clinical studies in dogs where the modified Mueller's manoeuvre was applied for the P di measurement, with the placement of two oesophageal balloon catheters, one in the oesophagus and one into the stomach, and the effect of different anesthetic protocols on diaphragmatic contractility was studied (Pavlidou et al, 2014, Pavlidou et al, 2013.…”

Section: Introductionmentioning

confidence: 99%

Trans-diaphragmatic pressure measurement as a prognostic factor in the Intensive Care Unit in dogs

Pavlidou

Savvas

2020

J Hellenic Vet Med Soc

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In the last decade, attempts to improve the quality of the services provided to the critically ill patients in the Intensive Care Unit (ICU) are of great interest in human medicine. The aim of the majority of the clinical studies is the correlation of the survival rate of a critically ill patient with specific prognostic factors at the time of admission. The detailed assessment of a patient at admission in the ICU and during hospitalization seems to affect the management and the outcome. The main aim of this study was to evaluate if the trans-diaphragmatic pressure measurement can be a prognostic factor of the outcome in the ICU in dogs. Thirty-one dogs, 21 male and 10 female was included in this prospective, cohort study. Age, breed, sex, body weight and clinical diagnosis were recorded. The type of admission, the mentation status, physiological and biochemical parameters were measured at the admission of the dog in the ICU. All the variables were assessed over the first 24 hours following ICU admission. The animals were allocated into sixgroups: peritonitis/intra-abdominal surgery, intra-thoracic surgery, respiratory disease, neurologic disease, neoplasia, and systematic disease. The trans-diaphragmatic pressure (Pdi) was measured under the same anesthetic level in all animals with two oesophageal balloon catheters. The most frequent problem for admission in ICU was peritonitis (5/31). Seventeen out of 31 were admitted in acute status while 14/31 had a chronic problem. Mean±standard deviation of Pdi was 10.7±5.6 mmHg and of lactate concentration 2.3±1.2 mmol/L. Both, they can predict outcome (p=0.071 and p=0.076, respectively). Seven out of 31 dogs died, 2 were euthanized and 22 were discharged from the ICU after hospitalization. The technique of Pdi measurement with balloon catheters can be successfully applied in dogs in the ICU. Pdi measurement, as well as lactate concentration may be used as prognostic indicators for the outcome, in dogs in the ICU. However, a bigger sample size is need to support these findings.

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Respiratory Disease

Brunson

Johnson

2014

Canine and Feline Anesthesia and Co‐Existing Disease

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The Effect of Four Anaesthetic Protocols for Maintenance of Anaesthesia on Trans-Diaphragmatic Pressure in Dogs

Cited by 9 publications

References 47 publications

The effect of aminophylline on trans-diaphragmatic pressure in isoflurane anaesthetised dogs undergoing castration

The effect of aminophylline on trans-diaphragmatic pressure in isoflurane anaesthetised dogs undergoing castration

Trans-diaphragmatic pressure measurement as a prognostic factor in the Intensive Care Unit in dogs

Respiratory Disease

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