The Effect of Folic Acid Supplementation in the Ovary and Upon Embryo Development

Abstract

Faculty of Natural and Environmental Sciences School of Biological Sciences Thesis for the degree of Doctor of Philosophy The Effect of Folic Acid Supplementation in the Ovary and Upon Embryo Development by Reyna Stephanie Penailillo Escarate Altered maternal nutrition around conception can affect oocyte and embryo development which influences later-life health outcomes. Low folate is related to poor reproductive outcomes. Folic acid (FA) supplementation and fortification have been effective strategies to avoid NTD. On the other hand, the FA levels in women of reproductive age are increased more than recommended, with unknown consequences. This project aims to determine the effect of high FA diet on the