“…Patients with the following diseases were excluded from this study: cancer, liver diseases, renal insufficiency, blood diseases, hyperthyroidism, thyroid dysfunction, systemic lupus erythematosus, malnutrition, pregnant woman, and supplemented folic acid and vitamin B 12 . Participating subjects were explained their participation rights and written informed consent was obtained, and were asked about excessive drinking (yes or no, it was defined as yes at least once a week and drinking over 45 degrees of alcohol more than 200 mL) and smoking habits (yes or no, nonsmokers including never smoking and stop smoking more than one year).…”