The effect of focused extracorporeal shock wave therapy on collagen matrix and gene expression in normal tendons and ligaments

Bosch, G.; Mos, Marieke de; Binsbergen, R. van; Schie, Hans T. M. van; Lest, Chris H.A. van de; Weeren, P. R. van

doi:10.2746/042516409x370766

Cited by 71 publications

(47 citation statements)

References 41 publications

(45 reference statements)

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“…Therefore, a possible mechanism for the upregulation of lubricin expression by ESWT involves the induction of appropriate cytokines: ESWT may increase TGF-β and BMP-7 expression in fibroblast-like cells in tendons and septa, which in turn increases lubricin expression in the local tissue. Additionally, ESWT has been hypothesized to induce an acute biochemical activation of latent matrix metalloproteinases (MMPs) (Bosch et al 2009). MMPs are known to activate latent TGF-β sequestered in the ECM (Jenkins 2008), possibly leading to lubricin upregulation.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal shockwave-induced expression of lubricin in tendons and septa

et al. 2011

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Lubricin, a lubricating glycoprotein that facilitates tendon gliding, is upregulated by mechanical as well as biochemical stimuli, prompting this study of its induction by extracorporeal shockwave therapy (ESWT). The objective of this study was to characterize and quantify the effect of ESWT on lubricin expression in tendons and septa in a rat model. Hindlimbs of six rats were treated with low-dose ESWT and those of another six with high-dose ESWT, using contralateral limbs as controls. After 4 days, resected samples were processed for immunolocalization of lubricin using a purified monoclonal antibody. ESWT was found to increase lubricin expression in both low-dose and high-dose ESWT-treated tendons and also in septa. Lubricin expression generally increased with increasing dose of ESWT. Increased lubricin expression may contribute to the beneficial effects of ESWT in providing pain and symptom relief in musculoskeletal disorders by decreasing erosive wear.

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Section: Discussionmentioning

confidence: 99%

Extracorporeal shockwave-induced expression of lubricin in tendons and septa

et al. 2011

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“…17 The anti-inflammatory effects, both trophic and metabolic rise subsequently and induce a more stable therapeutic effect. 4,18 The subjects in the supplement group showed better pain regression in the later followups even though there were no significant differences between the two groups. This result can be understood considering that neurotrophics need more time to optimize therapeutic effects.…”

Section: Discussionmentioning

confidence: 99%

Comparison of shock wave therapy and nutraceutical composed of Echinacea angustifolia, alpha lipoic acid, conjugated linoleic acid and quercetin (perinerv) in patients with carpal tunnel syndrome

Notarnicola

Maccagnano

Tafuri

et al. 2015

Int J Immunopathol Pharmacol

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Even though the initial treatment of carpal tunnel syndrome (CTS) is conservative, knowledge of the clinical effects of supplements and of some methods of physiotherapy is still preliminary. Many biological mechanisms can support the administration of shock wave therapy (ESWT) or of alpha lipoic acid (ALA) based nutraceutical, conjugated linoleic acid (GLA), anti-oxidants and Echinacea angustifolia for CTS. The shock waves reduce the nerve compression, produce an anti-inflammatory action, and accelerate the regeneration of neuropathy. ALA and GLA induce antioxidant protective actions, reduce inflammation, promote neuroregeneration, and decrease pain. The Echinacea modulates the endogenous cannabinoid system.The aim of study is to verify the efficiency of shock wave therapy versus nutraceutical composed of ALA, GLA, and Echinacea in CTS. Sixty patients were enrolled in this study and they were randomly assigned to one of two treatments. Both groups showed significant improvements in pain, symptoms' severity and functional scores, and electrodiagnostic results until the sixth month. We verified a trend to a better pain regression in the nutraceutical group. The presence of the medicinal Echinacea represents an added value to the antioxidant effect in ALA and GLA, which can justify this result. ESWT or the association of ALA, GLA, and Echinacea proved to be two effective treatments for controlling symptoms and improving the evolution of CTS.

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“…Adverse reactions such as pain, increased lameness, hematoma and inflammation have been reported in horses. Studies on focused ESWT show a disorganization of collagen network in the treated normal tendon 38 , as well as a potential to increase bone microcracking 39 . These studies recommend restricted exercise after treatment.…”

Section: Indications and Contraindicationsmentioning

confidence: 99%

“…Normal tendons treated with ESWT showed a transient stimulation of metabolism in tendinous structures, but six weeks after treatment the metabolism and level of glucosaminoglycans was lower than before treatment. 38,39 Shockwaves may affect sensory nerve fibers, resulting in an analgesic effect. No cutaneous analgesia or changes in measured gait analysis parameters were recognized following ESWT treatment of equine high palmar/plantar metacarpal/metatarsal pain, but reduced gait asymmetry was found at 72 hours following treatment.…”

Section: Treatment Parametersmentioning

confidence: 99%

Physical treatment of the equine athlete

Bergh¹

2014

Equine Sports Medicine and Surgery

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The effect of focused extracorporeal shock wave therapy on collagen matrix and gene expression in normal tendons and ligaments

Cited by 71 publications

References 41 publications

Extracorporeal shockwave-induced expression of lubricin in tendons and septa

Extracorporeal shockwave-induced expression of lubricin in tendons and septa

Comparison of shock wave therapy and nutraceutical composed of Echinacea angustifolia, alpha lipoic acid, conjugated linoleic acid and quercetin (perinerv) in patients with carpal tunnel syndrome

Physical treatment of the equine athlete

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