The effect of fluoxetine on ischemia–reperfusion after aortic surgery in a rat model

Güner, İbrahim; Yaman, Muhittin Onur; Aksu, Uğur; Uzun, Duygu; Erman, Hayriye; Inceli, Meliha Sengezer; Gelışgen, Remise; Yelmen, Nermin; Uzun, Hafize; Şahin, Gülderen

doi:10.1016/j.jss.2014.02.033

Cited by 11 publications

(15 citation statements)

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“…Groups were compared by unpaired Student's t-test. treatment improves antioxidant defense and decreases oxidative stress [47,48]. In addition to the observation related to oxidative stress, our study also showed that Fx increased the CS activity in brainstem and tendency in heart; in concordance with our observation, previous studies with Fx or imipramine (also a neurotransmitter reuptake inhibitor) showed that serotonin modulation increases CS activity in amygdala [49], corpus striatum [50], hypothalamus [18], and skeletal muscle [18].…”

Section: Cardiovascular Variabilitysupporting

confidence: 91%

Serotonin modulation in neonatal age does not impair cardiovascular physiology in adult female rats: Hemodynamics and oxidative stress analysis

et al. 2016

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Section: Cardiovascular Variabilitysupporting

confidence: 91%

Serotonin modulation in neonatal age does not impair cardiovascular physiology in adult female rats: Hemodynamics and oxidative stress analysis

et al. 2016

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“…Occlusion and reperfusion of the infrarenal abdominal aorta (IAA) occurs in humans during perivascular surgery [1] and when applied in experimental animal models [2,3]. This method is known to cause ischemia–reperfusion injury (IRI) in various distant organs, such as the kidney, heart, and lungs, which may lead to multiple organ dysfunction syndrome (MODS).…”

Section: Introductionmentioning

confidence: 99%

“…Reactive oxygen species (ROS) have a key role in the development of ischemia-reperfusion-induced lung injury [5], with a crucial role in the sequence of events leading to lung failure [2]. ROS, derived from H 2 O 2 , NADPH (Nicotinamide adenine dinucleotide phosphate) oxidase, and other enzymatic reactions are toxic molecules that lead to tissue damage.…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Thymosin β4 against Abdominal Aortic Ischemia–Reperfusion-Induced Acute Lung Injury in Rats

et al. 2019

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Background and objectives: Ischemia–reperfusion (IR) caused by infrarenal abdominal aorta cross-clamping is an important factor in the development of ischemia–reperfusion injury in various distant organs. Materials and Methods: We investigated potential antioxidant/anti-inflammatory effects of thymosin beta 4 (Tβ4) in a rat model of abdominal aortic surgery-induced IR. Tβ4 (10 mg/kg, intravenous (i.v.)) was administered to rats with IR (90-min ischemia, 180-min reperfusion) at two different periods. One group received Tβ4 1 h before ischemia, and the other received 15 min before the reperfusion period. Results: Results were compared to control and non-Tβ4-treated rats with IR. Serum, bronchoalveolar lavage fluid and lung tissue levels of oxidant parameters were higher, while antioxidant levels were lower in the IR group compared to control. IR also increased inflammatory cytokine levels. Tβ4 reverted these parameters in both Tβ4-treated groups compared to the untreated IR group. Conclusions: Since there is no statistical difference between the prescribed results of both Tβ4-treated groups, our study demonstrates that Tβ4 reduced lung oxidative stress and inflammation following IR and prevented lung tissue injury regardless of timing of administration.

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“…Beneficial effects of selective serotonin reuptake inhibitors, i.e. fluvoxamine were demonstrated on ischemia-reperfusion injury, which is in line with the observation that serotonin is activated during ischemia-reperfusion and triggers contractile dysfunction and pathological apoptosis [44, 45]. Paroxetine was discussed a new pharmacological agents for heart failure therapy [46] (see Fig.…”

Section: In Patients With Cardiovascular Disorders Use Serotonin Reupmentioning

confidence: 63%

Depression in the Context of Medical Disorders: New Pharmacological Pathways Revisited

Lang¹,

Walter²

2017

Neurosignals

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The depressive state has been characterised as one of elevated inflammation, changed cardiovascular parameters and a deranged metabolic situation all of which holds promise for a better understanding and handling of treatment-resistance in affective disorders as well as for future developments in treatment algorithms. In this context several biomarkers are differentially regulated by antidepressant treatment and connected to metabolic, inflammatory, cardiovascular and apoptotic components of the pathophysiology, i.e. adiponectin, apolipoprotein-B, B-type natriuretic peptide, cortisol, CRP, cysteine, homocysteine, fibrinogen, adiponectin, BMI, glycated hemoglobin A1c, leptin, interferon-gamma, high-density lipoprotein, interleukin interleukin-1alpha, -1beta, -2, -4, -5, -6, -8, -10, -12, -13, -17, insulin-like growth factor-1, low-density lipoprotein, myeloperoxidase, osteoprotegerin, tumour necrosis factor alpha, troponins, triglycerides etc. In this context antidepressants exert different modulatory effects on the outcome, incidence and mortality concerning several severe disorders, i.e. cancer, diabetes, stroke, inflammation, stroke and cardiovascular risk. Vice versa different drugs used in the treatment of these disorders have a favourable effect in depressive states, e.g. statins, aspirine, NSAIDs, pioglitazone, celecoxib, peroxisome proliferator-activated receptor-gamma agonists and minocycline. In this review, actions of different antidepressant treatment strategies on cancer, stroke, diabetes and cardiovascular disorders are shown and the influence on the outcome of the disorders is differentially discussed. In conclusion a hypothetic model for the implication of actual findings in everyday clinical practice is proposed. In this context personalized treatment could be used to tailor treatment to specific individuals according to their clinical endophenotypes. Moreover a potential target for the development of novel intervention strategies might be used.

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The effect of fluoxetine on ischemia–reperfusion after aortic surgery in a rat model

Cited by 11 publications

References 41 publications

Serotonin modulation in neonatal age does not impair cardiovascular physiology in adult female rats: Hemodynamics and oxidative stress analysis

Serotonin modulation in neonatal age does not impair cardiovascular physiology in adult female rats: Hemodynamics and oxidative stress analysis

Protective Effect of Thymosin β4 against Abdominal Aortic Ischemia–Reperfusion-Induced Acute Lung Injury in Rats

Depression in the Context of Medical Disorders: New Pharmacological Pathways Revisited

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