The effect of fluoride varnishes on caries lesions: an in vitro investigation

Dehailan, Laila Al; Martínez-Mier, E. Ángeles; Lippert, Frank

doi:10.1007/s00784-015-1648-4

Cited by 41 publications

(47 citation statements)

References 35 publications

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“…In perspective, it would thus be interesting to develop formulations containing the present essential oil incorporated in a sustained release system that increases the drug exposure time and maintains the effective concentration in the oral cavity. Alternative formulations have been proposed to enhance the antimicrobial action of natural products, including chewing gum, 28 sustained drug release systems 29,30 and denture relining with resilient materials. 31 Figure 3.…”

Section: Discussionmentioning

confidence: 99%

Cymbopogon citratus essential oil: effect on polymicrobial caries-related biofilm with low cytotoxicity

Oliveira¹,

Borges²,

Brighenti

et al. 2017

Braz. oral res.

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The objective of this study was to evaluate the effects of Cymbopogon citratus essential oil and its main compound (citral) against primary dental colonizers and caries-related species. Chemical characterization of the essential oil was performed by gas chromatography/mass spectroscopy (GC/MS), and the main compound was determined. Antimicrobial activity was tested against Actinomyces naeslundii, Lactobacillus acidophilus, S. gordonii, S. mitis, S. mutans, S. sanguinis and S. sobrinus. Minimum inhibitory and bactericide concentrations were determined by broth microdilution assay for streptococci and lactobacilli reference, and for clinical strains. The effect of the essential oil on bacterial adhesion and biofilm formation/disruption was investigated. Negative (without treatment) and positive controls (chlorhexidine) were used. The effect of citral on preformed biofilm was also tested using the same methodology. Monospecies and microcosm biofilms were tested. ANOVA or Kruskal-Wallis tests were used (α=0.05). Cytotoxicity of the essential oil to human keratinocytes was performed by MTT assay. GC/MS demonstrated one major component (citral). The essential oil showed an inhibitory effect on all tested bacterial species, including S. mutans and L. acidophilus. Essential oil of C. citratus (10X MIC) reduced the number of viable cells of lactobacilli and streptococci biofilms (p < 0.05). The essential oil inhibited adhesion of caries-related polymicrobial biofilm to dental enamel (p < 0.01). Citral significantly reduced the number of viable cells of streptococci biofilm (p < 0.001). The essential oil showed low cytotoxicity to human keratinocytes. Based on these findings, this study can contribute to the development of new formulations for products like mouthwash, against dental biofilms.

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Section: Discussionmentioning

confidence: 99%

Cymbopogon citratus essential oil: effect on polymicrobial caries-related biofilm with low cytotoxicity

Oliveira¹,

Borges²,

Brighenti

et al. 2017

Braz. oral res.

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“…Different kinds of fluoride products have been available for local fluoride delivery, such as toothpaste, mouthwash, varnishes, and gels, etc. [33]. However, such kinds of delivery demonstrate a limited control of sustained release, which could easily be diluted or cleared by saliva and chewing in several hours, so that bioavailability is greatly reduced [87].…”

Section: Remineralizing Ddsmentioning

confidence: 99%

“…Antibiotics or antibacterial agents like chlorhexidine were loaded for local biofilm inhibition [19,31,32]. Remineralizing agents like fluoride were also loaded on varnish or gels for caries prevention and treatment for early caries, which are now commercialized and have been used in clinics [33]. With the application of nanotechnology, micro/nano-scaled carriers are reported in the DDS for oral diseases, which is more comfortable and multifunctional [34].…”

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confidence: 99%

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

et al. 2020

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The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.Molecules 2020, 25, 516 2 of 29 problems. For example, systemic antibiotics such as tetracycline, beta-lactam antibiotics, nitroimidazoles have been used, especially in cases of periodontal diseases and peri-implantitis [12]. However, systemic antibiotics could cause problems like drug resistance, dysbacteriosis, and systemic side effects [13,14]. The antibacterial effect is also limited as very little could arrive at the oral lesion area after systemic circulation [15][16][17]. Fluoride in drinking water has been used for the prevention of dental caries but might cause excessive intake, leading to fluorosis [18]. Therefore, local drug therapy is now more considered for oral infectious diseases [19,20]. However, the conventional forms of local therapy, like drug suspension or rinse of anti-infection agents, could be easily washed off and thus could not last long in the oral cavity. Complex local lesions like deep periodontal pockets and teeth fissure are also difficult to reach. In order to improve the effect of prophylaxis and treatment, more precise targeting therapy is quite essential [21,22]. Therefore, drug delivery systems have drawn great attention in recent decades in oral infectious diseases. Drug delivery systems (DDS) are devices that can transport and release the therapeutic agents or bioactive substances to certain sites at certain rates in vivo [23,24], usually composed of the carriers and associated therapeutics [25]. They have been widely explored in biomedical research. With local drug administration and controlled drug release, DDS could provide higher curative efficiency and fewer side effects [23,26,27]. With all these advantages, DDS has been reported w...

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“…The anticariogenic activity of CPP‐ACP, as well as its synergistic effect with fluoride, have been demonstrated. MI Varnish enhances enamel's resistance against acidity and rehardens early carious lesions . Furthermore, it releases phosphate and greater amounts of fluoride and calcium ions than other varnishes …”

Section: Introductionmentioning

confidence: 99%

Preventive effects of carbon dioxide laser and casein phosphopeptide amorphous calcium phosphate fluoride varnish on enamel demineralization: A comparative, in vitro study

Abufarwa

Noureldin

Azimaie

et al. 2019

J of Invest & Clin Dent

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Aim The aim of the present study was to compare the effects of carbon dioxide (CO2) laser and casein phosphopeptide amorphous calcium phosphate (CPP‐ACP)fluoride varnish on enamel demineralization. Methods Human teeth were randomly assigned to three groups. The enamel was treated with fluoride varnish, 10.6 μm CO2 laser, or no treatment (control), followed by 9 days of pH cycling. Baseline and final FluoreCam images were used to quantify the area, intensity, and impact of demineralization; cross‐sectional microhardness was used to measure the mechanical properties of the enamel. Results There were statistically‐significant changes in the area, intensity and impact of demineralization in the control and laser groups (P < 0.05), but not in the fluoride group. The control group showed a significantly greater area and impact of enamel demineralization compared to the fluoride group. The area of demineralization in the laser group was significantly greater than that of the fluoride group. Enamel demineralization of the laser and control groups was comparable. The fluoride group showed statistically‐significant harder enamel than the control at 20, 40, and 60 μm depths; the laser group enamel was significantly harder than the control at 20 and 40 μm depths. The fluoride group showed statistically‐significant harder enamel than the laser group at 20 μm depth. Conclusions CPP‐ACP fluoride varnish is more effective than CO2 in preventing enamel demineralization.

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The effect of fluoride varnishes on caries lesions: an in vitro investigation

Abstract: Fundamental, comparable research on FV and how different formulations affect early caries lesion rehardening, fluoride release into saliva, and uptake by teeth is scarce.

Cited by 41 publications

References 35 publications

Cymbopogon citratus essential oil: effect on polymicrobial caries-related biofilm with low cytotoxicity

Cymbopogon citratus essential oil: effect on polymicrobial caries-related biofilm with low cytotoxicity

Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Preventive effects of carbon dioxide laser and casein phosphopeptide amorphous calcium phosphate fluoride varnish on enamel demineralization: A comparative, in vitro study

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