The Effect of Fluid Therapy on Alveolar Arterial Oxygen Gradient in Brain-Dead Organ Donors1

Brain death and its implications for management of the potential organ donor

“…However, hypervolemia may aggravate right ventricular dysfunction 80 and cause rapid deterioration of lung function. 81,82 The goal should therefore be to achieve normovolemia if thoracic organs are to be harvested. On the other hand, kidney function seems to benefit from a more aggressive fluid regimen, 83 making it necessary to balance the antagonistic interests of organs related to fluid resuscitation.…”

Anesthetic considerations in organ procurement surgery: a narrative review

“…For example, moderate intravascular fluid administration may have no adverse effect on the liver or kidneys, but this fluid could potentially have deleterious effects on the transplanted lung or pancreas. 31 Accordingly, some surgeons consider intraoperative administration of fluid as the preferred method to improve blood pressure in a hypotensive donor patient, with vasopressors being relatively contraindicated due to vasoconstriction and decreased blood flow to vital organs. [32][33][34] Nevertheless, the dangers to long-term organ function arising from hypotension-related organ hypoperfusion and reduced oxygen delivery may outweigh the risks associated with using vasopressors.…”

Manejo del potencial donante cadáver

“…dosis bajas de vasopresores 20,22 . Esto es importante pues el aporte excesivo de fluidos puede afectar la viabilidad de órganos, particularmente de los pulmones 23,24 . Con respecto al tipo de fluidos no hay evidencias claras sobre cuál es el más apropiado, pero los cristaloides parecen ser preferibles al uso de coloides en esta condición 1 .…”