The Effect of Fish Oil Supplementation on Heart rate in Healthy Danish Infants

Lauritzen, Lotte; Christensen, Jeppe H.; Damsgaard, Camilla T.; Michaelsen, Kim Fleischer

doi:10.1203/pdr.0b013e318186e5c5

Cited by 24 publications

(15 citation statements)

References 36 publications

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“…Lower HR has been reported in infants who are supplemented with DHA and arachidonic acid (ARA) and with fish oil (23, 27), however, we did not find an effect of prenatal supplementation with DHA on HR. All children in the study were receiving DHA and ARA at the time they were tested, either from infant formula or human milk feeding.…”

Section: Discussioncontrasting

confidence: 97%

Prenatal DHA supplementation and infant attention

et al. 2016

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Background Results of randomized trials on the effects of prenatal docosahexaenoic acid (DHA) on infant cognition are mixed, but most trials have used global standardized outcomes, which may not be sensitive to effects of DHA on specific cognitive domains. Methods Women were randomized to 600 mg/d DHA or a placebo for the last two trimesters of pregnancy. Infants of these mothers were then followed on tests of visual habituation at 4, 6, and 9 months of age. Results DHA supplementation did not affect look duration or habituation parameters but infants of supplemented mothers maintained high levels of sustained attention (SA) across the first year; SA declined for the placebo group. The supplemented group also showed significantly reduced attrition on habituation tasks, especially at 6 and 9 months. Conclusion The findings support with the suggestion that prenatal DHA may positively affect infants’ attention and regulation of state.

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Section: Discussioncontrasting

confidence: 97%

Prenatal DHA supplementation and infant attention

et al. 2016

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“…This meta-analysis included 30 randomized trials related to fish oil and showed that omega-3 fatty acids reduced the HR by 1.6 bpm (95% CI 0.6-2.5). Since then, similar results have been obtained in different populations: heart transplant recipients, 42 infants, 43 patients with ischaemic cardiomyopathy, 44 hypertension or hypercholesteroleamia. 45 With respect to alcohol, a recently published cross-sectional study has shown a lower HR among moderate alcohol drinkers.…”

Section: Discussionsupporting

confidence: 64%

Adherence to the Mediterranean dietary pattern and heart rate in the SUN project

García–López

Martínez-González

Basterra-Gortari

et al. 2012

Eur J Prev Cardiolog

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Background: A higher heart rate has been related to an increase of total and cardiovascular mortality. The aim of this study was to assess the relation between adherence to the Mediterranean diet and heart rate. Design: The SUN project is an ongoing multipurpose cohort study based on university graduates from Spain. Methods: This cross-sectional study included 15,863 participants of the SUN project. Adherence to the Mediterranean dietary pattern was assessed through a validated 136-item food frequency questionnaire and calculated according to the 9-point score proposed by Trichopoulou. Multiple linear regression models were fitted to assess the relationship between adherence to the Mediterranean dietary pattern and heart rate and 95% confidence intervals were calculated. Results: The multivariable-adjusted models revealed that participants with a high adherence (7-9 points) to the Mediterranean dietary pattern had a heart rate 2.2 bpm (95% CI 1.4-3.1) lower than participants with a low adherence (0-2 points). Conclusions: Adherence to the Mediterranean dietary pattern seems to be related to a lower heart rate

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“…Given the association between BP and behavioral effects of FO observed by others (Harbild et al 2013), we speculate that the effect of FO on BP may in part occur via the autonomic nervous system and might be related to a calming effect of FO in boys. In support of this hypothesis, our earlier infant study found that FO supplementation gave longer mean RR interval among boys (Lauritzen et al 2008), which corresponds to a lower HR. However, in the present study, HR tended to increase with FO supplementation and higher HR was also observed among 2 -year-old boys whose mothers had been supplemented with FO during lactation (Larnkjaer et al 2006).…”

Section: Discussionmentioning

confidence: 61%

Effects on metabolic markers are modified by PPARG2 and COX2 polymorphisms in infants randomized to fish oil

et al. 2014

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Long-chain n-3 fatty acids (n-3 LCPUFA) improve blood pressure (BP) and lipid profile in adults and improve insulin sensitivity in rodents. We have previously shown that n-3 LCPUFA reduces BP and plasma triacylglycerol (TAG) in infants. Few studies have found effects on glucose homeostasis in humans. We explored possible effect modification by FADS, PPARG2, and COX2 genotypes to support potential effects of n-3 LCPUFA on metabolic markers in infants. Danish infants (133) were randomly allocated to daily supplementation with a teaspoon (*5 mL/day) of fish oil (FO) or sunflower oil (SO) from 9 to 18 months of age. Before and after the intervention, we assessed BP, erythrocyte n-3 LCPUFA, plasma lipid profile, insulin, and glucose in addition to functional single nucleotide polymorphisms in FADS, PPARG2, and COX2. At 18 months, plasma TAG was lower in the FO compared with SO group (p = 0.014). This effect was modified by PPARG2-Pro12Ala, as TAG only decreased among heterozygotes. FO supplemented PPARG2 Pro12Ala heterozygotes also had decreased plasma glucose compared with the SO group (p = 0.043). The effect of FO on mean arterial BP at 18 months was gender dependent (p = 0.020) and reduced in boys only (p = 0.028). Diastolic BP was, however, lower among all FO supplemented homozygous COX2-T8473C variant allele carriers compared with the SO group (p = 0.001). In conclusion, our results confirm that FO supplementation in late infancy reduces TAG and BP and indicates that the effects are mediated via peroxisome proliferator-activated receptor-c and cyclooxygenase-2. Furthermore, FO reduced plasma glucose only in PPARG2 heterozygotes.

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The Effect of Fish Oil Supplementation on Heart rate in Healthy Danish Infants

Cited by 24 publications

References 36 publications

Prenatal DHA supplementation and infant attention

Prenatal DHA supplementation and infant attention

Adherence to the Mediterranean dietary pattern and heart rate in the SUN project

Effects on metabolic markers are modified by PPARG2 and COX2 polymorphisms in infants randomized to fish oil

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