The Effect of Fine-Needle Aspiration Biopsy on the Thyroid Scan

Gordon, Donald L.; Wagner, Robert H.; Dillehay, Gary; Khedkar, Nanda; Martinez, Charles J.; Bayer, William; Brooks, Marion H.

doi:10.1097/00003072-199306000-00007

Cited by 19 publications

(21 citation statements)

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“…According to the literature, it seems likely that oncocytic tumors are particularly susceptible to post-FNA necrosis. Gordon et al [7] reported an overall incidence of 9.8%, very high compared to ours. The mechanism of infarction and its high incidence in Hurthle cell neoplasms is not known.…”

Section: Discussioncontrasting

confidence: 49%

“…Tissue damage resulting from the use of fine-needles is a rare occurrence, unlike large needle biopsy where hemorrhagic necrosis and granulation tissue is often noted along the needle track [ Fig.2a] in the surgically excised specimen. However, several morphologic alterations following FNA biopsy have been reported in the recent literature [2][3][4][5][6][7][8][9][10][11]. KeyhaniRofagha et al [2] and Layfield and Jones [3] reported the subtotal necrosis of two Hurthle cell tumors subsequent to FNA.…”

Section: Discussionmentioning

confidence: 99%

“…Perhaps the increased vascularity makes the Hurthle cell neoplasm more susceptible to infarction. Reasons offered [7][8][9] included interruption of microvascular supply, compromised vascular supply from the extraction of large amounts of tissue, traumatic venous thrombosis, rough needle use, and multiple passes with rigorous aspiration. Post-FNA infarcted thyroid nodules may show all types of neoplasms.…”

Section: Discussionmentioning

confidence: 99%

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Infarction of Hürthle Cell Tumor of Thyroid Following Fine Needle Aspiration

Varma¹,

S²

2017

JCR

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Background: Fine needle aspiration is widely recognized as an important test in the evaluation of thyroid nodules. Complications of the procedure are uncommon with partial or incomplete infarction of the thyroid neoplasm being rare. Amongst the thyroid neoplasm, Hurtle cell neoplasms are more prone to such infarctions. Case Report: We report a case of Hurthle cell neoplasm which had undergone an infarction post fine needle aspiration. Conclusion: An infarcted nodule in thyroidectomy specimen should induce the histopathologist to look carefully for detailed morphologic features.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Infarction of Hürthle Cell Tumor of Thyroid Following Fine Needle Aspiration

Varma¹,

S²

2017

JCR

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“…These include: hemorrhage, infarction, fibrosis, cystic degeneration, and necrosis. 12,13 LiVolsi and Merino 12 classified such alterations as acute and chronic. The acute category comprised hemorrhage and granulation tissue formation, whereas tumor herniation into the capsule, vascular "invasion," and papillary endothelial hyperplasia were regarded as chronic changes leading to major diagnostic difficulties.…”

Section: Discussionmentioning

confidence: 99%

Post-Fine-Needle Aspiration Spindle Cell Nodules of the Thyroid (PSCNT)

Baloch

LiVolsi

1999

Am J Clin Pathol

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A b s t r a c tWe have encountered similar spindle cell proliferations in the thyroid gland of 10 patients who had previously undergone a fine-needle aspiration (FNA) procedure. Most of these lesions appeared circumscribed and consisted of an exuberant proliferation of plump spindle cells, thin-walled blood vessels, and hemosiderin-laden macrophages. This microscopic pattern shares the features described by Proppe et al. 3 We wish to designate such lesions, which appear after thyroid FNA, as "post-FNA spindle cell nodules of the thyroid." Materials and MethodsThe personal consultations of one of us (V.A.L.) and the surgical pathology files at the University of Pennsylvania Medical Center (Philadelphia) for the years January 1996 through December 1997 were searched to retrieve all cases of thyroid resection with a preceding history of FNA. All microscopic slides were reviewed. A total of 10 cases were selected for this study. Clinical information was sought from referring pathologists and patient records. Immunohistochemical stains were performed in 9 cases using the avidin-biotin-peroxidase 7 0

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“…Previous reports have indicated that invasive techniques, such as fine needle aspiration biopsy, can occasionally produce extensive tissue damage (e.g. Gordon et al, 1993;Lee et al, 1994). Insertion of needle electrodes is also part of invasive procedures including measurements of pH or oxygen, measurement of interstitial fluid pressure and laser Doppler measurements of tumour blood flow.…”

Section: Experimental Therapeuticsmentioning

confidence: 99%

Local hypoxia is produced at sites of intratumour injection

2002

Br J Cancer

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Intratumour injection, commonly used for gene or drug delivery but also associated with needle biopsy or insertion of invasive measuring devices, may damage tumour microvessels. To examine this possibility, SCCVII tumours grown subcutaneously in C3H mice were injected with a 26 gauge needle containing 0.1 ml of the fluorescent dye Hoechst 33342 to label cells lining the track of the needle. Hoechst-labelled cells sorted from these tumours were more sensitive to killing by hypoxic cell cytotoxins (tirapazamine, RSU-1069) and less sensitive to damage by ionizing radiation. Hoechst-labelled cells also bound the hypoxia marker pimonidazole when given by i.p. injection. Intratumour injection transiently increased hypoxia from 18 to 70% in the tumour cells adjacent to the track of the needle. The half-time for return to pre-treatment oxygenation was about 30 min; oxygenation of tumour cells along the track had recovered by 20 h after intratumour injection. This effect could have significant implications for intratumour injection of drugs, cytokines or vectors that are affected by the oxygenation status of the tumour cells as well as potential effects on biodistribution via local microvasculature.

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The Effect of Fine-Needle Aspiration Biopsy on the Thyroid Scan

Cited by 19 publications

References 0 publications

Infarction of Hürthle Cell Tumor of Thyroid Following Fine Needle Aspiration

Infarction of Hürthle Cell Tumor of Thyroid Following Fine Needle Aspiration

Post-Fine-Needle Aspiration Spindle Cell Nodules of the Thyroid (PSCNT)

Local hypoxia is produced at sites of intratumour injection

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