The Effect of Fibrin Sealant Combined with Fibrinolysis Inhibitor on Reducing the Amount of Lymphatic Leakage after Axillary Evacuation in Breast Cancer

Mustonen, Paula; Härmä, Markku; Eskelinen, Matti

doi:10.1177/145749690409300307

Cited by 44 publications

(28 citation statements)

References 10 publications

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“…In this situation, fibrin sealants have demonstrated no significant effect on the incidence of postoperative seromas [20][21][22], the volume of drainage output [22], or the time to drain removal [20]. Other studies have reported that the volume of fluid aspirated from seromas in the fibrin treatment group was significantly greater than the volume in the control group [23,24].…”

Section: Clinical Impact Of Postoperative Seromamentioning

confidence: 98%

Randomized, Prospective Study of TissuGlu® Surgical Adhesive in the Management of Wound Drainage Following Abdominoplasty

et al. 2011

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Section: Clinical Impact Of Postoperative Seromamentioning

confidence: 98%

Randomized, Prospective Study of TissuGlu® Surgical Adhesive in the Management of Wound Drainage Following Abdominoplasty

et al. 2011

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“…A reduction in postoperative drainage and hospital stay were observed following use of fibrin glue, but it did not affect delayed seroma formation [49]. However, the use of fibrin glue or peri-operative and postoperative administration of a fibrinolysis inhibitor does not reduce seroma formation [50]. …”

Section: Obliteration Of Dead Spacementioning

confidence: 99%

Seroma Formation after Breast Cancer Surgery: What We Have Learned in the Last Two Decades

2012

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Formation of a seroma most frequently occurs after mastectomy and axillary surgery. Prolonged drainage is troublesome as it increases the risk for infection and can significantly delay adjuvant therapy. Seroma has been defined as serous fluid collection under the skin flaps or in the axillary dead space following mastectomy and/or axillary dissection. Because the true etiology of a seroma is unknown, a multifactorial-causation hypothesis has been accepted. Surgical factors include technique, extent of dissection and the surgical devices used for dissection. Obliteration of dead space with various flap fixation techniques, use of sclerosants, fibrin glue and sealants, octreotide, and pressure garments have been attempted with conflicting results and none have been consistent. Early movement of the shoulder during the postoperative period may increase the formation of seroma, although delayed physiotherapy decreases the formation of seroma. A detailed analysis of the use of drains showed that use of single or multiple drains, early or late removal, and drains with or without suction are not significantly different for the incidence of seroma. Although there is evidence for reduced seroma formation after early drain removal, very early removal within 24 hours seems to increase formation of seroma. No patient or tumor factors seem to affect seroma formation except body mass index and body weight. Consensus is lacking among studies/trials with different groups producing conflicting evidence. Besides a few established factors such as body mass index, the use of electrocautery for dissection, early drain removal, low vacuum drains, obliteration of dead space, and delayed shoulder physiotherapy, most of the hypothesized causes have not been demonstrated consistently. Thus, seroma remains a threat to both the patient and surgeon. Recurrent transcutaneous aspiration remains the only successful management.

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“…Bei verschiedenen plastisch-chirurgischen Operationen wurde daher bereits der präventive Einsatz von Gewebeklebern zur Vermeidung von Seromen untersucht, so z. B. bei Axilladissektion [13], Gesichtstraffung [14] und Lidplastik [12].…”

Section: Fibrinkleber Und Serombildung Nach Abdominoplastikunclassified

“…Mustonen et al [13] fanden in einer prospektiven Studie über den Gebrauch von Fibrinklebern bei Axilladissektionen eine einheitliche Inzidenz von Seromen, jedoch in einer quantitativ deutlich geringeren Ausprägung bei den verklebten Achselhöhlen. Ebenfalls signifikant positive Auswirkungen von Fibrinklebern zeigten sich bei der Bildung von Seromen bei Gesichtstraffungen [14] und der Hebung von M.-latissimus-dorsi-Lappenplastiken [9].…”

Section: Introductionunclassified

Fibrinkleber und Serombildung nach Abdominoplastik

Toman

Buschmann

Muehlberger

2007

Chirurg

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The Effect of Fibrin Sealant Combined with Fibrinolysis Inhibitor on Reducing the Amount of Lymphatic Leakage after Axillary Evacuation in Breast Cancer

Abstract: Potentially, fibrin sealant combined with fibrinolysis inhibitor might be used for the treatment of post- axillary evacuation lymphorrhea and seroma.

Cited by 44 publications

References 10 publications

Randomized, Prospective Study of TissuGlu® Surgical Adhesive in the Management of Wound Drainage Following Abdominoplasty

Randomized, Prospective Study of TissuGlu® Surgical Adhesive in the Management of Wound Drainage Following Abdominoplasty

Seroma Formation after Breast Cancer Surgery: What We Have Learned in the Last Two Decades

Fibrinkleber und Serombildung nach Abdominoplastik

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