The effect of fibrin sealant on the prevention of seroma formation after postbariatric abdominoplasty

Lee, Johnson C; Teitelbaum, Jason; Shajan, Josh K; Naram, Aparajit; Chao, Jerry

doi:10.1177/229255031202000317

Cited by 30 publications

(11 citation statements)

References 14 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we found a signi cant decrease in the total volume of aspirated uid in the group who received brin glue compared to the control. This nding is in accordance with the results documented by other authors who used commercial brin glue in their interventions [5,[7][8][9]. However, con icting results were found by other authors, who reported inconclusive results or even harmful effects of brin glue which were explained by the presence of drains that may interfere with the maturation of the brin clot and the blockage of the lymphatic vessels [16][17][18].…”

Section: Discussionsupporting

confidence: 90%

“…Fibrin glue, light-activated brin sealant, and transdermal photopolymerized adhesive have been associated with reduction in the uid build-up post mastectomy through various studies [6][7][8][9]. Fibrin glue acts by lessening the number of disrupted lymphatics and minute vessels during axillary dissection hence resulting in lowering of seroma output [6,10] and provide hemostasis by controlling the hematomas which may delay wound healing.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Autologous Fibrin Glue on Seroma Reduction after Modified Radical Mastectomy for Breast Cancer: A Randomized Controlled Trial

Faisal

Salem

Kamel

et al. 2020

Preprint

View full text Add to dashboard Cite

Introduction: Breast cancer stands out as the second most common cancer in the world with incidence 35.1% of all malignancies among females in Egypt. Fluid build-up after breast surgery is still the most annoying complication which leads to worse outcome. We aimed to evaluate whether autologous fibrin glue might lessen the formation of seroma following modified radical mastectomy. Methods: This was a randomized controlled trial designed to configure the effect of autologous fibrin glue given in the study group using the drain in comparison to a control group who received the drain only; seroma volume was calculated every 24 hrs. For all of the cases. The drains were removed when the daily drainage was less than 30 ml for 3 consecutive days. Results: We recruited 30 patients to each of the two groups. Age, pathology, breast cancer stage, number of lymph nodes and tumour size did not differ significantly between groups. A comparison of the median days to drain removal showed 8 days reduction in median days to drain removal compared in the intervention group (7 days) than the control (15 days). The patients in the fibrin glue group had a significantly lower cumulative drain output volume (mean ± SD of 505.6 ± 209.3 ml) than those in the control group (1674.1 ± 1373.8 ml). Additionally, the patients treated with fibrin glue had a significantly shorter postoperative length of stay (8.5 (7–10) days) than the controls (15 (10–23) days. Conclusions: Autologous fibrin glue significantly decrease seroma formation post-modified radical mastectomy. Research Registry Unique Identifying Number: researchregistry5372.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Effect of Autologous Fibrin Glue on Seroma Reduction after Modified Radical Mastectomy for Breast Cancer: A Randomized Controlled Trial

Faisal

Salem

Kamel

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Wattin and Look [27] have suggested the use of a spray version of the glue to allow a better distribution over the entire surface, while a recent Canadian study demonstrates that the fibrin glues are a useful adjunct during surgical wound closure and significantly decrease seroma formation in patients undergoing postbariatric abdominoplasty [28].…”

Section: Discussionmentioning

confidence: 99%

The Use of a Fibrin Glue with a Low Concentration of Thrombin Decreases Seroma Formation in Postbariatric Patients Undergoing Circular Abdominoplasty

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Its role in seroma prevention has been studied with varying results in mastectomy and thyroidectomy patients. [9][10] Human fibrin glue (HFG) is formed of two components contained in separate vials; the first component is a freeze-dried concentrate of clotting proteins, mainly fibrinogen, Factor XIII and fibronectin (the sealant) and the second substance is freeze dried thrombin (the catalyst). The first component is reconstituted with an aprotinin solution that inhibits tissue fibrinolysis.…”

Section: Introductionmentioning

confidence: 99%

Role of fibrin glue in seroma reduction after modified radical mastectomy

Fawzy¹,

Gaber²,

Farid³

2017

Int Surg J

View full text Add to dashboard Cite

INTRODUCTIONBreast cancer is the second leading cause of cancer death among women. The surgical treatment is the best choice for those patients. 1 Since the first mastectomy which was carried out by Halsted in 1882, surgeons have faced several problems such as skin flaps necrosis, wound breakdown, seroma, infection, nerve injuries, lymphedema, phantom breast syndrome and hematoma. Seroma, which is a subcutaneous collection of serous fluid, is a common problem in breast surgery where it develops under the skin flaps during mastectomy or in the axillary dead space after axillary dissection. It usually resolves within a few weeks, so many surgeons view this problem as an unavoidable nuisance rather than a serious complication. 3Seroma formation is the most frequent postoperative complication after breast cancer surgery. Incidence of seroma formation after breast surgery varies between 2.5% and 51%. Although seroma is not life threatening, it can lead to significant morbidity (e.g. flap necrosis, wound dehiscence, predisposes to sepsis, prolonged recovery period, multiple physician visits) and it may delay adjuvant therapy.1 The pathogenesis of seroma has not been fully elucidated. It has been hypothesized that seromas form as an exudate from an acute inflammatory ABSTRACT Background: Seroma is one of the most common morbidity occurring post modified radical mastectomy (MRM). It can delay post-operative initiation of adjuvant therapy. This study was designed to determine the role of fibrin glue spray in reduction of seroma volume and duration after breast surgeries. Methods: A prospective, randomized, controlled study over forty female patients who underwent (MRM) was done. The study cohort was randomized into control group where only conventional drain placement was used and experimental group where double dose of fibrin glue has been sprayed to the axillary and mammary beds plus conventional drain placement. Data regarding the amount of drained fluid in the first post-operative day, hospital stay, length of drain placement, amount and duration of post-operative seroma, number of excised lymph nodes (L. Ns) and pathological results were recorded. Results: No difference in mean age, number of excised L. Ns and rate of post-operative infection between both groups was detected. There was significant reduction in hospital stay time favouring fibrin glue group (p=0.006). Fibrin glue group had a significant reduction in the length of drain placement (p=0.001). The amount of postoperative serous fluid was reduced and the incidence of occurrence of post-operative seroma was (7/20) 35% in control group compared to (1/20) 5% in fibrin glue group giving significant reduction in incidence and amount. Conclusions: Use of fibrin glue sealant during MRM resulted in noticeable and significant decrease of post-operative rate of seroma formation, its amount and the length of drain placement.

show abstract

The effect of fibrin sealant on the prevention of seroma formation after postbariatric abdominoplasty

Abstract: Fibrin sealant was a useful adjunct during surgical wound closure and significantly decreased seroma formation in patients undergoing postbariatric abdominoplasty.

Cited by 30 publications

References 14 publications

Effect of Autologous Fibrin Glue on Seroma Reduction after Modified Radical Mastectomy for Breast Cancer: A Randomized Controlled Trial

Effect of Autologous Fibrin Glue on Seroma Reduction after Modified Radical Mastectomy for Breast Cancer: A Randomized Controlled Trial

The Use of a Fibrin Glue with a Low Concentration of Thrombin Decreases Seroma Formation in Postbariatric Patients Undergoing Circular Abdominoplasty

Role of fibrin glue in seroma reduction after modified radical mastectomy

Contact Info

Product

Resources

About