The Effect of Fibrin Glue on Skin Grafts in Infected Sites

Jabs, Arthur D.; Wider, Todd M.; DeBellis, Joseph; Hugo, Norman E.

doi:10.1097/00006534-199202000-00011

Cited by 55 publications

(19 citation statements)

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“…Via hemostasis and adhesion, fibrin glue fixes the graft and creates an ultrafine fibrin sealant matrix structure to diffuse nutrients and cytokines, promote neovascularization, and facilitate growth of fibroblasts and capillary endothelial cells by serving as a scaffold. This structure then promotes phagocytosis and blocks the source of infection (Gibran et al 2007; Mittermayr et al 2006; Currie et al 2001; Foster et al 2008; Jabs et al 1992). …”

Section: Discussionmentioning

confidence: 99%

Fixation of split-thickness skin graft using fast-clotting fibrin glue containing undiluted high-concentration thrombin or sutures: a comparison study

et al. 2016

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ObjectiveFor skin defects caused by full-thickness burns, trauma, or tumor tissue excision, skin grafting is one of the most convenient and useful treatment methods. In this situation, graft fixation is important in skin grafting. This study was performed to compare the effectiveness of skin graft fixation between high-concentration fibrin sealant and sutures. There have been numerous studies using fibrin sealant for graft fixation, but they utilized slow-clotting fibrin sealant containing less than 10 IU/mL thrombin.MethodTwenty-five patients underwent split-thickness skin grafting using fast-clotting fibrin sealant containing 400 IU/mL thrombin, while 30 patients underwent grafting using sutures. Rates of hematoma/seroma formation, graft dislocation, graft necrosis, and graft take were investigated postoperatively. The graft surface area was calculated using Image J software (National Institutes of Health, Bethesda, MD, USA).ResultAfter 5 days, rates of hematoma/seroma formation and graft dislocation were 7.84 and 1.29% in group I, and 9.55 and 1.45% in group II, respectively. After 30 days, rates of graft necrosis and graft take were 1.86 and 98.14% in group I, and 4.65 and 95.35% in group II. Undiluted fibrin sealant showed significantly superior results for all rates (p < 0.05) except graft dislocation.ConclusionWhen high-concentration fast-clotting fibrin sealant was applied to skin grafts without dilution, no difficulty was experienced during surgery. Sealant showed superior results compared with sutures and had an excellent graft take rate.Level of evidenceII.

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Section: Discussionmentioning

confidence: 99%

Fixation of split-thickness skin graft using fast-clotting fibrin glue containing undiluted high-concentration thrombin or sutures: a comparison study

et al. 2016

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“…However, the clinical experience has been that fibrin glue offers no impediment to skin grafting, and this is consistent with the authors' own experience, and infection has not been found experimentally to be a problem. 18 Clinically, Vibe and Pless demonstrated an increase in graft take from 83 percent to 92 percent in 20 patients treated with fibrin glue. 19 This difference was magnified in areas of mobility and folds, where graft take increased from 44 percent to 88 percent in those treated with fibrin glue.…”

Section: Skin Graftsmentioning

confidence: 95%

The Use of Fibrin Glue in Plastic Surgery

Mooney

Loh²,

Pu³

2009

Plastic and Reconstructive Surgery

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“…The rapid wound coverage achieved through this method provides a barrier against infection. 20, 21 Application of fibrin sealant significantly decreases the length of surgical procedures, especially when grafts must be applied to the face or other areas where standard fixation methods are difficult to use. The formation of hypertrophic scarring may also be reduced as a result of better re-vascularization, graft adherence, and subsequent acceleration of wound closure.…”

Section: Fibrin Sealant For Graft Fixationmentioning

confidence: 99%

Wound Coverage Technologies in Burn Care

Jeschke

Finnerty

Shahrokhi

et al. 2013

Journal of Burn Care & Research

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Improvements in burn wound care have vastly decreased morbidity and mortality in severely burned patients. Development of new therapeutic approaches to increase wound repair has the potential to reduce infection, graft rejection, and hypertrophic scarring. The incorporation of tissue engineering techniques, along with the use of exogenous proteins, genes, or stem cells to enhance wound healing, heralds new treatment regimens based on the modification of already existing biological activity. Refinements to surgical techniques have enabled the creation of protocols for full facial transplantation. With new technologies and advances such as these, care of the severely burned will undergo massive changes over the next decade. This review centers on new developments that have recently shown great promise in the investigational arena.

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The Effect of Fibrin Glue on Skin Grafts in Infected Sites

Cited by 55 publications

References 0 publications

Fixation of split-thickness skin graft using fast-clotting fibrin glue containing undiluted high-concentration thrombin or sutures: a comparison study

Fixation of split-thickness skin graft using fast-clotting fibrin glue containing undiluted high-concentration thrombin or sutures: a comparison study

The Use of Fibrin Glue in Plastic Surgery

Wound Coverage Technologies in Burn Care

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