The effect of fibrin glue on the postoperative lymphatic leakage after D2-lymphadenectomy and gastrectomy in patients with gastric cancer

Mahmoodzadeh, Habibollah; Rahimi-Movaghar, Ehsanollah; Omranipour, Ramesh; Shirkhoda, Mohammad; Jalaeefar, Amirmohsen; Miri, Seyed Rouhollah; Sharifi, Amirsina

doi:10.1186/s12893-021-01168-5

Cited by 5 publications

(2 citation statements)

References 33 publications

(10 reference statements)

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“…• Fibrin-glue in the operative bed reduced postoperative lymphatic leakage after gastrectomy and D2 dissection and the patients were discharged earlier [68].…”

Section: Reconstruction Type Eso-jejuno-anastomosismentioning

confidence: 98%

Anastomotic Leakage after Gastrectomy for Gastric Cancer

Seicean,

Puscasu,

Gheorghiu

et al. 2023

JGLD

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Anastomotic leakage (AL) constitutes a prominent cause of significant morbidity following gastrectomy for gastric cancer. The manifestation of AL typically occurs within 7 to 10 days post-surgery, with reported incidence rates of 5.8-6.7% for open gastrectomy and 3.3-4.1% for laparoscopic gastrectomy. Various predisposing risk factors have been identified, including the individual nutritional status (excluding obesity) and preoperative corticotherapy. Interestingly, the administration of neoadjuvant therapies appears to reduce the AL occurrence. In the context of distal gastrectomies, the rates of AL are comparable between laparoscopic, robotic, and open approaches. The total gastrectomies have higher AL rate compared to distal gastrectomies, which are considered the preferred approach. Prophylactic drainage measures have not demonstrated efficacy in preventing AL. As for postoperative management, conservative treatment is indicated for patients presenting with mild clinical symptoms and increased inflammatory blood tests. This approach involves fasting, enteral or parenteral nutrition, administration of antibiotics, and percutaneous drainage. For small AL, endoscopic therapies such as stents, vacuum therapy, clips, suturing devices, and injections are appropriate treatment options. In cases of high-volume fistulas, severe sepsis or failure of previous therapies, surgical reoperation becomes the ultimate solution.

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“…• Fibrin-glue in the operative bed reduced postoperative lymphatic leakage after gastrectomy and D2 dissection and the patients were discharged earlier [68].…”

Section: Reconstruction Type Eso-jejuno-anastomosismentioning

confidence: 98%

Anastomotic Leakage after Gastrectomy for Gastric Cancer

Seicean,

Puscasu,

Gheorghiu

et al. 2023

JGLD

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“…In a multicenter RCT carried out in three institutions in Italy, the rate of unfavorable outcomes was compared in a group of patients receiving fibrin sealants as an adjuvant for preventing air leaks in patients having lung resection ( 12 ). Following these surgeries, broncopleural fistulas and air leaks are also frequent side effects ( 13 , 14 ). The researchers discovered that there was no statistically significant difference in the rate of adverse events between patients who received fibrin sealant and those who did not, with a follow-up duration of 30—40 days ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

The safety and efficacy of fibrin sealant for thyroidectomy: a systematic review and meta-analysis of randomized controlled trials

Koerniawan,

Candrawinata,

Tjahyanto

et al. 2023

Front. Surg.

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Fibrin sealants have recently been thoroughly studied in several surgical specialties; however, results are conflicting. We aimed to examine the safety and efficacy of fibrin sealant patients having thyroidectomies. A thorough, systematic literature search was carried out using the terms thyroidectomy and fibrin sealant using PubMed, Cochrane Library, and Clinicaltrials.gov on December 25, 2022. The primary outcome of interest in this review was the amount of drainage, whereas hospitalization, the length of drain retention, and temporary dysphonia were secondary outcomes. Our meta-analysis (n = 249) showed that application of fibrin sealant is associated with lesser total drainage [SMD −2.76 (−4.83, −0.69); P = 0.009; I2 97%], but not with retention time of drainage [SMD −2.35 (−4.71, 0.01); P = 0.05; I2 98%], hospitalization time [SMD −1.65 (−3.70, 0.41); P = 0.12; I2 97%], and transient dysphonia [RR 1.01 (0.27, 3.82); P = 0.99; I2 0%]. The systematic review found that the use of fibrin sealant in thyroid surgery is positive in total volume drainage but not with the retention time of drainage, hospitalization time, and transient dysphonia. It is notable to remember that this interpretation is complicated by uneven, occasionally subpar technique and trial reporting, according to this systematic review's findings.

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