The effect of fibrin glue and peritoneal grafts in the prevention of intraperitoneal adhesions

Gauwerky, J. F. H.; Mann, Johannes F.E.; Bastert, G.

doi:10.1007/bf02389540

Cited by 23 publications

(9 citation statements)

References 7 publications

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“…Thus the deliberate placement of fibrin at a surgical site might enhance adhesion formation. 10 This is unsupported by several studies using fibrinderived materials in animals [11][12][13][14][15][16][17][18][19][20][21][22] and humans. [23][24][25][26] One reason fibrin may be used to reduce rather than enhance adhesions is that once polymerization is complete, an adhesion barrier may form that cannot stick to other surfaces.…”

Section: Introductionmentioning

confidence: 84%

The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

Wiseman

Lyachovetsky²,

Keidan

et al. 2003

J Biomed Mater Res

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The objective of the research was to determine the effect of the type, dose, and volume of anti-fibrinolytic agents (tranexamic acid, aprotinin) added to fibrin formulations, on adhesion development. Adhesions were induced in 228 male rats by creating apposing parietal and visceral peritoneal defects. Animals were randomized to receive no treatment or a fibrin formulation containing aprotinin or tranexamic acid. Seven days later the incidence of adhesions, and the force and energy required to detach them, were determined. Adhesions developed in 13/13 rats in the control and aprotinin groups. Treatment with fibrin (100 mg/ml tranexamic acid) resulted in adhesions in 4/14 rats (as strips, p < or = 0.0005), 4/10 rats (as spray, p < or = 0.0036), and 12/15 rats (by drip). The reduction of adhesions was dependent on the concentration of tranexamic acid with strip and spray application. Using commercial formulations, tranexamic-acid-containing fibrin (10/15, p = 0.042), but not aprotinin-containing fibrin (13/15), reduced the incidence of side-wall adhesions from 15/15 in controls. Fibrin containing either tranexamic or aprotinin reduced the incidence and severity of adhesions. This effect was greater when tranexamic acid was used and was dependent on the mode of administration, the volume, and to a degree, the concentration of tranexamic acid.

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Section: Introductionmentioning

confidence: 84%

The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

Wiseman

Lyachovetsky²,

Keidan

et al. 2003

J Biomed Mater Res

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“…Fibrin glue can be used effectively for ovarian reconstruction and is a good means to completely avoid sutures. Although there are some reported animal studies in which fibrin glue inhibits intra-abdominal adhesion formation [4,5], Gauwerky et al [9] could not find any significant difference between covering the peritoneal defects with fibrin glue and not doing so.…”

Section: Discussionmentioning

confidence: 95%

Postoperative Adhesion Formation following Ovarian Reconstruction with Fibrin Glue in the Rabbit

Bilgin¹,

Cengiz²,

Demir³

1995

Gynecol Obstet Invest

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To compare postoperative adhesion formation following ovarian reconstruc tion with fibrin glue or the microsurgical suturing technique, an experimental study was performed on sixteen adult female rabbits. While left ovaries were reapproximated with 6-0 coated polyglactin using a microsurgical technique, right ovaries were reconstructed with fibrin glue following ovarian bisection. Four weeks later, second-look laparotomies were performed to evaluate the adnexal adhesions. These were scored according to the American Fertility Society classification. Mean adnexal adhesion scores were 8.2 ± 2.3 in the sutured ovary and 5.0 ± 1.1 in the glued ovary (p > 0.05). Ovarian reconstruc tion with fibrin glue does not reduce postoperative adhesion when compared with the usual suturing technique.

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“…In a study by Gauwerky et al [19], a fibrin glue covering of a peritoneal lesion determined a higher postoperative adhesion score compared to the contralateral uncovered lesion. In two other experimental models [6,7], the fibrin glue-covcred side had fewer adhesions than the control side; in both these studies, however, sutures were placed on both the fibrin glue and control sides.…”

Section: Discussionmentioning

confidence: 99%

Use of Fibrin Sealant for Reproductive Surgery: A Randomized Study in the Rabbit Model

Marana

Muzii²,

Catalano³

et al. 1996

Gynecol Obstet Invest

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The present study was undertaken to compare adhesion formation and reproductive outcome after reproductive surgery with or without the application of fibrin sealant. At laparotomy, the ovaries and uterine horns of 20 rabbits were longitudinally incised on the antimesenteric side using a monopolar microneedle. At random, one ovary and the ipsilateral uterine horn were covered with fibrin sealant, while those on the contralateral side were left uncovered without application of sutures. The rabbits were then mated, and 2 weeks later a second-look laparotomy was performed by a blinded observer. No statistically significant differences were found in postoperative adhesions, number of corpora lutea in each ovary, number of embryos in the ipsilateral uterine horn, and nidation index for each side. Fibrin sealant for conservative surgery does not appear to significantly affect either postoperative adhesion formation or reproductive outcome.

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The effect of fibrin glue and peritoneal grafts in the prevention of intraperitoneal adhesions

Cited by 23 publications

References 7 publications

The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

Postoperative Adhesion Formation following Ovarian Reconstruction with Fibrin Glue in the Rabbit

Use of Fibrin Sealant for Reproductive Surgery: A Randomized Study in the Rabbit Model

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